pharmacopeia

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Put two or three records next to each other and contrast their class, mechanism, indications, identifiers, and chemistry. Reads straight from the existing drug records — a reference contrast, never a recommendation.

MetforminGlipizide
At a glance
Metforminmetformin
Actoplus MetGlucophageGlumetzaInvokamet
Glipizideglipizide
Glucotrol
Mechanism

Metformin is an antihyperglycemic agent which improves glucose tolerance in patients with type 2 diabetes mellitus, lowering both basal and postprandial plasma glucose. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.

The primary mode of action of glipizide in experimental animals appears to be the stimulation of insulin secretion from the beta cells of pancreatic islet tissue and is thus dependent on functioning beta cells in the pancreatic islets. In humans, glipizide appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets.

Molecular targets
  • Insulin Receptor
  • Insulin Receptor
Indications
  • & USAGE Metformin hydrochloride tablets are indicated as an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients 10 years of age and older with type 2 diabetes mellitus. Metformin hydrochloride tablets are biguanide indicated as an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients 10 years of age and older with type 2 diabetes mellitus.E11.9
  • Glipizide Tablets USP are indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.E11.9
Structure

3-(diaminomethylidene)-1,1-dimethylguanidine

CN(C)C(=N)N=C(N)N

N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-5-methylpyrazine-2-carboxamide

CC1=CN=C(C=N1)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3

Identifiers
RxCUI
6809
ATC
A10BA
UNII
786Z46389E
RxCUI
4821
ATC
A10BB
UNII
X7WDT95N5C
Note. Side-by-side data is taken verbatim from each drug record. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.

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