Aluminum Chloride

Mechanism-of-action class: Bone Surface Interactions.

• Use extra effective at reducing underarm perspiration

Directions apply to underarms only apply at bedtime apply sparingly apply only a few strokes under each arm

For external use only

1. 1Drug Ineffective128.8%
2. 2Rash128.8%
3. 3Product Dose Omission Issue85.8%
4. 4Dermatitis Atopic75.1%
5. 5Headache75.1%
6. 6Nausea75.1%
7. 7Off Label Use75.1%
8. 8Pain75.1%
9. 9Pruritus75.1%
10. 10Anxiety64.4%
11. 11Discomfort64.4%
12. 12Fatigue64.4%
13. 13Hyperhidrosis64.4%
14. 14Diarrhoea53.6%
15. 15Fall53.6%

Recent PubMed references pinned to Aluminum Chloride as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Toward a Molecular Framework of Systemic Multi-Organ Toxicity Induced by Chronic Aluminum Chloride Exposure.
  Molecules (Basel, Switzerland) · 2026 · Ali Agha ASA, Khaleel S, Abdelaziz HMA, et al.
  PMID 42197282DOI 10.3390/molecules31101728
• Enhancing rye seedlings with melatonin to thrive in repeated freeze-thaw cycles and aluminum chloride stress.
  Functional plant biology : FPB · 2025 · Bashir K, Bao GZ, Ali S, et al.
  PMID 42093025DOI 10.1071/FP24279
• Aluminum Chloride-Driven Neurodegeneration: Interlinking Redox Imbalance, Inflammation Cascade, and Excitotoxic Damage Across Molecular and Behavioral Domains.
  Molecular neurobiology · 2026 · Dhurandhar Y, Tomar S, Singh AP, et al.
  PMID 42049988DOI 10.1007/s12035-026-05891-z
• Liraglutide attenuates aluminum chloride-induced Alzheimer's disease in rats by modulating the oxLDL/LPA/LPAR1 pathway.
  Communications biology · 2026 · Abo El-Magd NF, Ramadan NM, Eraky SM, et al.
  PMID 41673096DOI 10.1038/s42003-026-09531-z
• Unraveling the molecular mechanisms of aluminium chloride-induced Alzheimer's disease.
  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026 · Paul R, Firdous SM
  PMID 41563682DOI 10.1007/s10534-026-00788-9
• Thymoquinone Attenuates Aluminum Chloride-Induced Testicular Injury by Inhibiting NLRP3/Caspase 1/IL-1β Inflammasome Signaling and Polarizing the Macrophages Toward Anti-Inflammatory M2 Phenotype.
  Cells · 2025 · Elhessy HM, Khattab BA, Badawy AM, et al.
  PMID 41369395DOI 10.3390/cells14231906
• Response of submerged macrophyte (Vallisneria natans) to flood-induced water depth, turbidity, and nutrient shocks.
  Journal of environmental management · 2025 · Wu Y, Zeng Z, Zhou C, et al.
  PMID 41319639DOI 10.1016/j.jenvman.2025.128163
• Protective role of catechin hydrate against aluminum chloride-induced nephrotoxicity via oxidative stress, NF-κB, Bax/Bcl-2, and PERK-CHOP pathways.
  European journal of pharmacology · 2025 · Yavuz H, Şimşek H, Akaras N, et al.
  PMID 41207358DOI 10.1016/j.ejphar.2025.178341

The 10 most recently updated of 104 ClinicalTrials.gov registrations naming Aluminum Chloride as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Safety and Immunogenicity of an Inactivated West Nile Virus Vaccine in Healthy Adults
  Active not recruiting · Phase 1 · Interventional · 30 enrolled · National Institute of Allergy and Infectious Diseases (NIAID)
  NCT06745921updated 2026-06-12
• A Safety and Immunogenicity Trial of Boost-2867 Vaccine, Via Intranasal and Intramuscular Routes
  Active not recruiting · Phase 1 · Interventional · 140 enrolled · National Institute of Allergy and Infectious Diseases (NIAID)
  NCT07221162updated 2026-06-05
• Safety and Efficacy of wSp Vaccine in Young Children
  Recruiting · Phase 2 · Interventional · 320 enrolled · Serum Life Science Europe GmbH
  NCT07216430updated 2026-06-02
• Randomized Trial of COVID-19 Booster Vaccinations (Cobovax Study)
  Completed · Phase 4 · Interventional · 451 enrolled · The University of Hong Kong
  NCT05057169updated 2026-05-15
• Safety and Immunogenicity of Clade C ALVAC and gp120 HIV Vaccine
  Completed · Phase 1 · Phase 2 · Interventional · 132 enrolled · National Institute of Allergy and Infectious Diseases (NIAID)
  NCT03284710updated 2026-05-04
• A Study of BEBT-209 Plus Chemotherapy in Patients With Locally Advanced or Metastatic Triple-Negative Breast Cancer
  Not yet recruiting · Phase 2 · Phase 3 · Interventional · 446 enrolled · BeBetter Med Inc
  NCT07544056updated 2026-04-22
• Actinic Keratoses Treated With 5-fluorouracil Plus Aluminum
  Recruiting · Phase 1 · Interventional · 32 enrolled · West Virginia University
  NCT07401277updated 2026-04-22
• Hyperthermia Combined With Hydrogen Peroxide Microneedle Patch for Viral Warts
  Recruiting · Interventional · 210 enrolled · First Hospital of China Medical University
  NCT07534865updated 2026-04-16
• Age-descending Study to Evaluate the Safety and Immunogenicity of the Cholera Conjugate Vaccine in Adults and Children
  Recruiting · Phase 2 · Interventional · 390 enrolled · International Vaccine Institute
  NCT07509047updated 2026-04-03
• Role of Combination Therapy of Glucose Insulin Potassium Infusion (GIK), Intravenous Hydrocortisone and Oral Sevelamer in Treatment of Acute Aluminum Phosphide Poisoned Cases Admitted to Intensive Care Unit (ICU) at Sohag University Hospitals.
  Not yet recruiting · Interventional · 74 enrolled · Sohag University
  NCT07451561updated 2026-03-05

Frequently asked questions

How does Aluminum Chloride work?

Mechanism-of-action class: Bone Surface Interactions.

What is Aluminum Chloride used for?

According to FDA labeling, Aluminum Chloride carries indications including: Use extra effective at reducing underarm perspiration. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Aluminum Chloride?

Aluminum Chloride is classified as Other anti-acne preparations for topical use, Bone Surface Interactions, Antiperspirant Activity, Astringent Activity, Bone Alteration.

What are the brand names for Aluminum Chloride?

Aluminum Chloride is marketed under brand names including Drysol, Hemox A, Hypercare, Lumicain, Xerac AC.