Aspartame

• USES: • For the temporary relief of symptoms including: • headache • liver support • muscle weakness • skin irritation • poor muscle coordination These statements are based upon homeopathic principles. They have not been reviewed by the Food and Drug Administration.ICD-10: R51.9

DIRECTIONS: 1-10 drops under the tongue, 3 times a day or as directed by a health professional. Consult a physician for use in children under 12 years of age.

If pregnant or breastfeeding, ask a health professional before use. Keep out of reach of children. In case of overdose, contact a physician or Poison Control Center right away. Tamper Evident: Sealed for your protection. Do not use if seal is broken or missing.

Recent PubMed references pinned to Aspartame as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Nanoencapsulation modulates aspartame metabolite exposure: Toxicokinetic, mechanistic, and pharmacological evaluation in a glucocorticoid dysfunction model.
  Toxicology and applied pharmacology · 2026 · Fawzy SF, Newairy AA, Ghareeb DA, et al.
  PMID 42002150DOI 10.1016/j.taap.2026.117827
• Molecular mechanism of aspartame recognition by the human sweet taste receptor T1R2-T1R3 revealed by homology modeling and molecular dynamics simulations.
  Journal of computer-aided molecular design · 2026 · Tong M, Duan S, Wang L, et al.
  PMID 41803465DOI 10.1007/s10822-026-00780-y
• Association between Aspartame Consumption and Cancer Risk: Evidence from a Large Prospective Cohort.
  The Journal of nutrition · 2026 · Zhu X, Welsh JA, McCullough ML, et al.
  PMID 41765137DOI 10.1016/j.tjnut.2026.101460
• Aspartame exacerbates cerebral ischemia-reperfusion injury via mitochondrial dysfunction and ERK/CREB1 pathway suppression.
  Ecotoxicology and environmental safety · 2026 · Bai Y, Feng J, Wu XY, et al.
  PMID 41762991DOI 10.1016/j.ecoenv.2026.119938
• Effects of Allulose vs Aspartame Consumption on Postprandial Glucagon-Like Peptide-1 Profiles and Metabolic Health: Protocol for a Randomized, Crossover, Double-Blind, Placebo-Controlled Trial.
  JMIR research protocols · 2026 · Busch S, Ferrario PG, Henk AK, et al.
  PMID 41713874DOI 10.2196/81857
• Aspartame enhances innate immunity and extends lifespan in Caenorhabditis elegans via autophagy pathway.
  Food research international (Ottawa, Ont.) · 2026 · Han C, Luo J, Ding L, et al.
  PMID 41652761DOI 10.1016/j.foodres.2025.118231
• Improving the communication of uncertainty in food safety on social media: a content analysis of aspartame risk messages.
  Frontiers in public health · 2025 · Chen Y, Luo S, Xu L, et al.
  PMID 41561861DOI 10.3389/fpubh.2025.1636789
• Investigating the relationship between taste perception of artificial sweeteners and cancer risk.
  Public health nutrition · 2026 · Crick DCP, Liu W, Hwang LD, et al.
  PMID 41521718DOI 10.1017/S1368980026101827

The 10 most recently updated of 68 ClinicalTrials.gov registrations naming Aspartame as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• The Effects of a Novel Mitochondrial Substrate Supplement on Exercise Performance and Cognitive Function
  Completed · Interventional · 40 enrolled · University of Exeter
  NCT06374641updated 2026-05-12
• Health Effects of Substituting Sugary Beverages With Artificially-sweetened Beverages or Water
  Active not recruiting · Interventional · 460 enrolled · Brigham and Women's Hospital
  NCT04567108updated 2026-05-01
• Acute Impact of Non-Sugar Sweeteners (Sucralose and Aspartame)
  Completed · Interventional · 14 enrolled · Virginia Polytechnic Institute and State University
  NCT07506564updated 2026-04-01
• SweetSpot - The Effect of Non-nutritive Sweeteners on Health
  Recruiting · Interventional · 60 enrolled · Wageningen University
  NCT07361406updated 2026-02-27
• Effect of Non-nutritive Sweeteners of High Sugar Sweetened Beverages on Metabolic Health and Gut Microbiome
  Active not recruiting · Interventional · 41 enrolled · Laval University
  NCT03259685updated 2025-12-26
• The Effects of Dietary Erythritol on Platelet Reactivity and Vascular Inflammation
  Recruiting · Interventional · 24 enrolled · University of California, Davis
  NCT05967741updated 2025-12-05
• Satiety and Alcohol Challenge
  Completed · Interventional · 64 enrolled · University of North Carolina, Chapel Hill
  NCT06576674updated 2025-12-05
• Non-Nutritive Sweetener Consumption and Glucose Homeostasis in Older Adults With Prediabetes
  Recruiting · Interventional · 30 enrolled · Virginia Polytechnic Institute and State University
  NCT05337098updated 2025-12-04
• Effects of Dietary Nitrate and Vitamin C Co-supplementation on Blood Pressure and Endothelial Function in Overweight Individuals
  Completed · Interventional · 15 enrolled · University of Nottingham
  NCT07242066updated 2025-12-02
• Reproducibility and Utility of OGTT in Acromegaly
  Completed · Interventional · 109 enrolled · Assistance Publique - Hôpitaux de Paris
  NCT04066569updated 2025-11-24

Frequently asked questions

What is Aspartame used for?

According to FDA labeling, Aspartame carries indications including: USES: • For the temporary relief of symptoms including: • headache • liver support • muscle weakness • skin irritation • poor muscle coordination These statements are based upon homeopathic principles. They have not been reviewed by the Food and Drug Administration.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.