pharmacopeia
GET
/api/v1/drug/aspirin
2D structure
2-acetyloxybenzoic acid
SMILES CC(=O)OC1=CC=CC=C1C(=O)O
InChIKey BSYNRYMUTXBXSQ-UHFFFAOYSA-N

Mechanism of action

Sourced from openFDA

Mechanism-of-action class: Cyclooxygenase Inhibitors.

Cyclooxygenase

Indications

Sourced from openFDA
  • Uses for the temporary relief of minor aches and pains or as recommended by your doctor. Because of its delayed action, this product will not provide fast relief of headaches or other symptoms needing immediate relief.ICD-10: R51.9

Dosage & administration

Sourced from openFDA

Directions drink a full glass of water with each dose adults and children 12 years and over: take 4 to 8 tablets every 4 hours not to exceed 48 tablets in 24 hours unless directed by a doctor children under 12 years: consult a doctor

Warnings & precautions

Sourced from openFDA

Reye's syndrome : Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye's syndrome, a rare but serious illness. Allergy alert : Aspirin may cause a severe allergic reaction, which may include: hives facial swelling shock asthma (wheezing) Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you: are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs [aspirin, ibuprofen, naproxen, or others] have 3 or more alcoholic drinks every day while using this product take more or for a longer time than directed Do not use if you are allergic to aspirin or any other pain reliever/fever reducer. if you have ever had an allergic reaction to his product or any of its ingredients Ask a doctor before use if stomach bleeding warning applies to you you have a history of stomach problems, such as heartburn you have high blood pressure, heart disease, liver cirrhosis, or kidney disease you are taking a diuretic you have asthma Ask a doctor or pharmacist before use if you are taking a prescription drug for gout diabetes arthritis Stop use and ask a doctor if an allergic reaction occurs. Seek medical help right away.

Approval history

Sourced from openFDA
  • Dec 28, 1981ANDAANDA086996Sandoz
  • Jan 14, 1998NDANDA020802Haleon Us Holdings
  • May 29, 1998ANDAANDA075141Galt Pharms
  • Aug 31, 1998ANDAANDA074951Stevens J
  • Nov 26, 2001ANDAANDA075794Perrigo
  • Nov 30, 2001ANDAANDA075231Lgm Pharma
  • Jun 13, 2007ANDAANDA078149Mpp Pharma
  • Mar 8, 2016ANDAANDA206392Amneal Pharms

FAERS reports

View JSON
Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
552,502 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
  1. 1Fatigue33,4936.1%
  2. 2Nausea28,4325.1%
  3. 3Dyspnoea28,2645.1%
  4. 4Diarrhoea27,5935.0%
  5. 5Drug Ineffective26,5294.8%
  6. 6Dizziness23,6154.3%
  7. 7Headache21,3693.9%
  8. 8Off Label Use19,9753.6%
  9. 9Asthenia19,5783.5%
  10. 10Fall19,3643.5%
  11. 11Pain19,1743.5%
  12. 12Vomiting16,8103.0%
  13. 13Pneumonia16,4223.0%
  14. 14Death15,4122.8%
  15. 15Myocardial Infarction15,2872.8%

Literature

View JSON

Recent PubMed references pinned to Aspirin as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

Clinical trials

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The 10 most recently updated of 2,152 ClinicalTrials.gov registrations naming Aspirin as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

Pharmacogenomics

View JSON

CPIC-curated drug–gene pairs for Aspirin. Levels describe the strength of curated evidence and guideline status — never a recommendation to test or to adjust therapy.

  • CYP2C9CPIC C
    CYP2C9 and NSAIDs
  • G6PDCPIC CClinPGx 3
    G6PD
  • GP1BACPIC D (provisional)ClinPGx 3
  • HLA-DPB1CPIC C (provisional)ClinPGx 2B
  • LTC4SCPIC D (provisional)ClinPGx 3
  • PTGS1CPIC D (provisional)ClinPGx 3

Frequently asked questions

How does Aspirin work?
Mechanism-of-action class: Cyclooxygenase Inhibitors.
What is Aspirin used for?
According to FDA labeling, Aspirin carries indications including: Uses for the temporary relief of minor aches and pains or as recommended by your doctor. Because of its delayed action, this product will not provide fast relief of headaches or other symptoms needing immediate relief.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
What class of drug is Aspirin?
Aspirin is classified as Other agents for local oral treatment, Platelet aggregation inhibitors excl. heparin, Salicylic acid and derivatives, Nonsteroidal Anti-inflammatory Drug, Platelet Aggregation Inhibitor, Cyclooxygenase Inhibitors, Decreased Platelet Activating Factor Production, Decreased Platelet Aggregation, Decreased Prostaglandin Production, Decreased Thromboxane Production.
What are the brand names for Aspirin?
Aspirin is marketed under brand names including Alka-Seltzer, Anacin, Anacin Advanced Headache Formula, Anacin Aspirin Regimen, Arthriten Inflammatory Pain, Ascomp, Aspergum, Aspi-Cor.
Note. Data for aspirin is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.

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