Carbamide Peroxide
/api/v1/drug/carbamide-peroxideMechanism of action
Sourced from openFDAMechanism-of-action class: Physiochemical Activity.
Indications
Sourced from openFDA- Uses for occasional use as an aid to soften, loosen, and remove excessive earwax
Dosage & administration
Sourced from openFDADirections FOR USE IN THE EAR ONLY Adults and children over 12 years of age: Tilt head sideways and place 5 to 10 drops into ear Tip of applicator should not enter ear canal Keep drops in ear for several minutes by keeping head tilted or placing cotton in the ear Use twice daily for up to 4 days if needed, or as directed by a doctor Any wax remaining after treatment may be removed by gently flushing the ear with warm water, using a soft rubber bulb ear syringe Children under 12 years: consult a doctor
Warnings & precautions
Sourced from openFDAFor use in the ear only Ask a doctor before use if you have ear drainage or discharge ear pain irritation, or rash in the ear dizziness an injury or perforation (hole) of the ear drum recently had ear surgery When using this product avoid contact with the eyes Stop use and ask a doctor if you need to use for more than 4 days excessive earwax remains after use of this product Keep out of reach of children. If swallowed get medical help or contact a Poison Control Center (1-800-222-1222) right away.
FAERS reports
- 1Diarrhoea357.4%
- 2Fatigue265.5%
- 3Pain234.8%
- 4Fall204.2%
- 5Headache194.0%
- 6Nausea194.0%
- 7Pneumonia194.0%
- 8Chronic Kidney Disease183.8%
- 9Dizziness183.8%
- 10Death173.6%
- 11Deafness163.4%
- 12Hypoacusis163.4%
- 13Off Label Use163.4%
- 14Weight Decreased163.4%
- 15Abdominal Pain142.9%
Literature
Recent PubMed references pinned to Carbamide Peroxide as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- Using violet light during in-office tooth bleaching to enhance the efficacy of carbamide peroxide without increasing bleaching sensitivity: a systematic review and meta-analysis.Lasers in medical science · 2025 · Bessa MS, Santos KS, Boa PWM, et al.PMID 40346438DOI 10.1007/s10103-025-04476-x
- The Effect of Whitening Agents (Whitening Rinse and Carbamide Peroxide) on Stained Flowable and Packable Composite Aligner Attachments.Clinical oral investigations · 2025 · Atik E, Kalyoncuoğlu ÜTPMID 40184006DOI 10.1007/s00784-025-06298-1
- Carbamide and Hydrogen Peroxide Bleaching Effect on Modern CAD/CAM Dental Ceramics: An Investigation on Ion Release and Surface Characteristics.The European journal of prosthodontics and restorative dentistry · 2025 · Vavrickova L, Schmidt J, Kapitan M, et al.PMID 40183313DOI 10.1922/EJPRD_2794Vavrickova08
- Effects of home bleaching agents on hybrid ceramics: mechanical properties and color change.BMC oral health · 2025 · Hafny WM, Ibrahim IM, El-Demellawy M, et al.PMID 39780126DOI 10.1186/s12903-024-05336-w
- Different daily times for at-home bleaching with 10% carbamide peroxide: A randomized single-blind, noninferiority controlled trial.Journal of the American Dental Association (1939) · 2025 · Terra RMO, Sutil E, Ferreira Cordeiro DC, et al.PMID 39779067DOI 10.1016/j.adaj.2024.10.010
- Color Change and Cytotoxic Effects of a Bleaching Gel With 22% Carbamide Peroxide Catalyzed by Manganese Oxide.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2025 · de Oliveira Ribeiro RA, Peruchi V, Sônego LNG, et al.PMID 39754476DOI 10.1111/jerd.13401
- Effect of carbamide peroxide treatment on the ion release of different dental restorative materials.BMC oral health · 2024 · Yilmaz MN, Gul PPMID 39277736DOI 10.1186/s12903-024-04876-5
- Effect of Successive At-home Bleaching Sessions on the Surface Properties, Biaxial Flexural Strength, and Reliability of CAD-CAM Monolithic Materials.Operative dentistry · 2024 · Queiroz J, Amaro LF, Massucatto LO, et al.PMID 39187958DOI 10.2341/23-030-L
Clinical trials
The 10 most recently updated of 36 ClinicalTrials.gov registrations naming Carbamide Peroxide as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.
- Impact of At-Home Dental Bleaching on Quality of Life Using OHIP-14Not yet recruiting · Interventional · 10 enrolled · University of ValenciaNCT07624344updated 2026-06-03
- Contribution of a* to Dental Bleaching After Combined Dental BleachingNot yet recruiting · Interventional · 10 enrolled · University of ValenciaNCT07560761updated 2026-05-06
- Effectiveness of Dental Bleaching Using Different Designs of 3D-Printed and Conventional Customized NightguardsRecruiting · Interventional · 40 enrolled · Universitat Internacional de CatalunyaNCT07464197updated 2026-03-16
- Clinical Evaluation of Enamel Microhardness Using Tooth Whitening AgentsCompleted · Interventional · 40 enrolled · Ultradent Products, Inc.NCT07165366updated 2026-01-20
- PATIENT SATISFACTION AND MASKING OF WHITE SPOT LESIONS AFTER HOME WHITENING WITH 10% CARBAMIDE PEROXIDEEnrolling by invitation · Interventional · 67 enrolled · Universidad Rey Juan CarlosNCT07247760updated 2025-11-25
- At-home Bleaching Using Clear RetainersCompleted · Interventional · 40 enrolled · Universidad Rey Juan CarlosNCT05835453updated 2025-10-03
- 16% Carbamide Peroxide Home Bleaching: Soft vs. Rigid Tray in a Randomized Blinded Equivalence TrialEnrolling by invitation · Interventional · 100 enrolled · Universidad Rey Juan CarlosNCT06881654updated 2025-10-02
- Effectiveness of 16% Carbamide Peroxide in Reducing Hypersensitivity During Alternate-day Home BleachingCompleted · Interventional · 110 enrolled · Universidad Rey Juan CarlosNCT06035588updated 2025-10-02
- A Comparative Study Between the Efficacy of Diode Laser and Nano-chitosan Gel on Activation of Non-vital in- Office Bleaching AgentEnrolling by invitation · Phase 1 · Interventional · 42 enrolled · Misr University for Science and TechnologyNCT06782087updated 2025-09-25
- Effect of 1.5% Potassium Oxalate on the Control of Tooth Sensitivity and Color Change After Home BleachingCompleted · Interventional · 50 enrolled · Universidade Federal do ParaNCT05028335updated 2024-12-10
Frequently asked questions
- How does Carbamide Peroxide work?
- Mechanism-of-action class: Physiochemical Activity.
- What is Carbamide Peroxide used for?
- According to FDA labeling, Carbamide Peroxide carries indications including: Uses for occasional use as an aid to soften, loosen, and remove excessive earwax. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
- What class of drug is Carbamide Peroxide?
- Carbamide Peroxide is classified as Physiochemical Activity, Decreased Intraocular Fluid Pressure, Decreased Skin Keratinization, Increased Protein Breakdown.
- What are the brand names for Carbamide Peroxide?
- Carbamide Peroxide is marketed under brand names including Auraphene-B, Auro Ear, Clearcanal, Debrox, E-R-O, Gly-Oxide, Mollifene, Murine Ear.
carbamide-peroxide is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.