Carbon Dioxide

Mechanism-of-action classes: Imaging Contrast Activity; X-Ray Contrast Activity.

• Jul 5, 2013NDANDA205815Linde Merchant Productions Inc
• Jul 5, 2013NDANDA205764Linde North America Inc
• Jul 5, 2013NDANDA205767Linde North America Inc
• Jul 20, 2013NDANDA205846Airgas Carbonic Inc
• Jul 21, 2013NDANDA205852Praxair Inc
• Jul 21, 2013NDANDA205849Praxair Inc
• Aug 2, 2013NDANDA205889Matheson Tri-gas Inc
• Sep 7, 2013NDANDA206025Airgas Usa Llc

1. 1Air Embolism3228%
2. 2Subcutaneous Emphysema2017%
3. 3Off Label Use1614%
4. 4Post Procedural Complication97.8%
5. 5Cardiac Arrest87.0%
6. 6Hypotension76.1%
7. 7Pneumoperitoneum76.1%
8. 8Drug Administration Error54.3%
9. 9Hypercapnia54.3%
10. 10Pco2 Increased54.3%
11. 11Pneumomediastinum54.3%
12. 12Intestinal Ischaemia43.5%
13. 13Respiratory Acidosis43.5%
14. 14Tachycardia43.5%
15. 15Atelectasis32.6%

Recent PubMed references pinned to Carbon Dioxide as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Microbial Controls of Primed CO(2) and CH(4) Release From Soils and Sediments Under Warming.
  Global change biology · 2026 · Jin P, Liu M, Ma D, et al.
  PMID 42261190DOI 10.1111/gcb.70961
• An aquaglyceroporin governs cellular water and CO(2) conductance relevant for vesicular mineral formation in a marine calcifier.
  Proceedings of the National Academy of Sciences of the United States of America · 2026 · Matt AS, Tetzlaff S, Jonusaite S, et al.
  PMID 42258730DOI 10.1073/pnas.2524614123
• Mapping CO(2) fixation to two effective parameters: A framework toward data-informed species and model comparison.
  Proceedings of the National Academy of Sciences of the United States of America · 2026 · Stillits A, Knudsen TE, Trusina A, et al.
  PMID 42247560DOI 10.1073/pnas.2609915123
• [Impacts of climate change on the functioning and productivity of agroecosystems: a focus on the impact of interactions between CO(2), temperature and water deficit].
  Comptes rendus biologies · 2026 · Bancal MO, Gawinowski M, Chenu K, et al.
  PMID 42240414DOI 10.5802/crbiol.197
• Equivalent of Carbon Dioxide at the Anaerobic Threshold Predicts Acute Exacerbations in Patients with Chronic Obstructive Pulmonary Disease: A Retrospective Cohort Study.
  International journal of chronic obstructive pulmonary disease · 2026 · Li Y, Li X, Lin F, et al.
  PMID 42239674DOI 10.2147/COPD.S613925
• CO(2)-dependent opening of connexin 43 hemichannels.
  eLife · 2026 · Dospinescu VM, Mascarenhas A, Butler J, et al.
  PMID 42234478DOI 10.7554/eLife.105989
• Spatially-Uneven Observations Cause Overestimation of Global Soil Respiration.
  Global change biology · 2026 · Cao L, Zhou T, Zeng J, et al.
  PMID 42233384DOI 10.1111/gcb.70956
• Phytochrome-Dependent Regulation of CO(2) Gas Exchange and Switching Between Respiratory and Photosynthetic Carbon Metabolism in Wheat Leaves.
  Physiologia plantarum · 2026 · Lyubimov V, Kosobryukhov A
  PMID 42229545DOI 10.1111/ppl.70962

The 10 most recently updated of 1,683 ClinicalTrials.gov registrations naming Carbon Dioxide as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Flow-Controlled Ventilation to Improve Postoperative Pulmonary Outcome After Thoracic Surgery
  Not yet recruiting · Interventional · 140 enrolled · Cantonal Hospital of St. Gallen
  NCT07623395updated 2026-06-12
• Transcutaneous Electrical Stimulation for Apnea Detected by Capnography
  Completed · Interventional · 60 enrolled · University of Toronto
  NCT06823661updated 2026-06-11
• Assessment of Continuous Measurement of Transcutaneous CO2 for Evaluation of Alveolar Dead Space During Exercise
  Completed · Interventional · 140 enrolled · Centre Hospitalier Metropole Savoie
  NCT03718780updated 2026-06-11
• Detecting Systemic Carbon Dioxide Levels With a Novel Biosensor
  Completed · Observational · 21 enrolled · The Hospital of Vestfold
  NCT06367686updated 2026-06-11
• Effectiveness and Safety of a Hydrating Gel Containing Polyvinyl Pyrrolidine, Algin and Hyaluronic Acid Applied After and Without Fractional CO₂ Laser Therapy
  Not yet recruiting · Interventional · 51 enrolled · Dr.dr.Irma Bernadette, SpKK (K)
  NCT07639151updated 2026-06-10
• Impact of Reverse Trendelenburg on ONSD in Obesity Surgery
  Completed · Interventional · 90 enrolled · Bagcilar Training and Research Hospital
  NCT07639502updated 2026-06-10
• High-flow Nasal Cannula Versus Conventional Oxygen During Awake Tracheal Intubation With Difficult Airways
  Recruiting · Interventional · 336 enrolled · Wenxian Li
  NCT07384494updated 2026-06-10
• CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy
  Recruiting · Interventional · 600 enrolled · Jasper A. Smits
  NCT05467683updated 2026-06-10
• End-Tidal CO2 (ETCO2) Trends in Out-of-Hospital Cardiac Arrest
  Active not recruiting · Observational · 3,500 enrolled · Office of the Medical Director for EMS in Oklahoma City and Tulsa
  NCT07632430updated 2026-06-09
• The Value of Methotrexate in NCES for Stable Vitiligo
  Active not recruiting · Phase 4 · Interventional · 20 enrolled · Cairo University
  NCT07352293updated 2026-06-08

Frequently asked questions

How does Carbon Dioxide work?

Mechanism-of-action classes: Imaging Contrast Activity; X-Ray Contrast Activity.

What class of drug is Carbon Dioxide?

Carbon Dioxide is classified as Medical gases, Radiographic Contrast Agent, Imaging Contrast Activity, X-Ray Contrast Activity, Decreased Metabolic Rate, Increased Medullary Respiratory Drive, Vasodilation.