pharmacopeia
GET
/api/v1/drug/cetirizine
2D structure
2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid
SMILES C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl
InChIKey ZKLPARSLTMPFCP-UHFFFAOYSA-N

Mechanism of action

Sourced from openFDA

Mechanism-of-action class: Histamine H1 Receptor Antagonists.

Histamine H1 Receptor

Indications

Sourced from openFDA
  • Uses temporarily relieves these symptoms due to hay fever or other upper respiratory allergies: runny nose sneezing itchy, watery eyes itching of the nose or throat

Dosage & administration

Sourced from openFDA

Directions may be taken with or without water chew or crush tablets completely before swallowing children 2 to under 6 years of age Chew and swallow 1 tablet (2.5 mg) once daily; If needed, dose can be increased to a maximum of 2 tablets (5 mg) once daily or 1 tablet (2.5 mg) every 12 hours. Do not give more than 2 tablets (5 mg) in 24 hours. adults and children 6 years and over Chew and swallow 2 tablets (5 mg) or 4 tablets (10 mg) once daily depending upon severity of symptoms; do not take more than 4 tablets (10 mg) in 24 hours. adults 65 years and over Chew and swallow 2 tablets (5 mg) once daily; do not take more than 2 tablets (5 mg) in 24 hours. children under 2 years of age ask a doctor consumers with liver or kidney disease ask a doctor

Warnings & precautions

Sourced from openFDA

Do not use if you have ever had an allergic reaction to this product or any of its ingredients or to an antihistamine containing hydroxyzine. Ask a doctor before use if you have liver or kidney disease. Your doctor should determine if you need a different dose. Ask a doctor or pharmacist before use if you are taking tranquilizers or sedatives. When using this product drowsiness may occur avoid alcoholic drinks alcohol, sedatives, and tranquilizers may increase drowsiness be careful when driving a motor vehicle or operating machinery Stop use and ask a doctor if an allergic reaction to this product occurs. Seek medical help right away. If pregnant or breast-feeding if breast-feeding: not recommended if pregnant: ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222)

Approval history

Sourced from openFDA
  • Dec 8, 1995NDANDA019835Kenvue Brands
  • Aug 10, 2001NDANDA021150Kenvue Brands
  • Mar 16, 2004NDANDA021621Kenvue Brands
  • Nov 16, 2007NDANDA022155Kenvue Brands
  • Jul 23, 2009NDANDA022429Bionpharma
  • Sep 3, 2010NDANDA022578Kenvue Brands
  • May 30, 2017NDANDA208694Harrow Eye
  • Oct 4, 2019NDANDA211415Esteve

FAERS reports

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Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
169,946 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
  1. 1Drug Ineffective21,87413%
  2. 2Fatigue19,06811%
  3. 3Pain16,0749.5%
  4. 4Off Label Use14,2688.4%
  5. 5Rash13,4367.9%
  6. 6Headache12,8417.6%
  7. 7Pruritus12,5897.4%
  8. 8Nausea12,0897.1%
  9. 9Dyspnoea11,3206.7%
  10. 10Abdominal Discomfort10,6396.3%
  11. 11Alopecia10,5306.2%
  12. 12Arthralgia10,4136.1%
  13. 13Diarrhoea10,0935.9%
  14. 14Hypersensitivity9,9265.8%
  15. 15Rheumatoid Arthritis9,2515.4%

Literature

View JSON

Recent PubMed references pinned to Cetirizine as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

Clinical trials

View JSON

The 10 most recently updated of 137 ClinicalTrials.gov registrations naming Cetirizine as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

Structural analogs

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Ranked by 2D fingerprint (Tanimoto) similarity over PubChem structures. Structural proximity only — not a claim of therapeutic equivalence.

Frequently asked questions

How does Cetirizine work?
Mechanism-of-action class: Histamine H1 Receptor Antagonists.
What is Cetirizine used for?
According to FDA labeling, Cetirizine carries indications including: Uses temporarily relieves these symptoms due to hay fever or other upper respiratory allergies: runny nose sneezing itchy, watery eyes itching of the nose or throat. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
What class of drug is Cetirizine?
Cetirizine is classified as Other antiallergics, Piperazine derivatives, Histamine-1 Receptor Antagonist, Histamine H1 Receptor Antagonists, Decreased Histamine Activity.
What are the brand names for Cetirizine?
Cetirizine is marketed under brand names including Aller-Tec, Aller-Tec D, Alleroff, Quzyttir, Wal Zyr 24 Hour Allergy, Wal Zyr D, Wal-Zyr, Zerviate.
Note. Data for cetirizine is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.

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