pharmacopeia
GET
/api/v1/drug/chlorpheniramine
2D structure
3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
SMILES CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2
InChIKey SOYKEARSMXGVTM-UHFFFAOYSA-N

Mechanism of action

Sourced from openFDA

Mechanism-of-action class: Histamine H1 Receptor Antagonists.

Histamine H1 Receptor

Indications

Sourced from openFDA
  • Uses temporarily relieves these symptoms due to hay fever (allergic rhinitis) or other upper respiratory allergies: sneezing runny nose itching of the nose or throat itchy, watery eyesICD-10: J30.9

Dosage & administration

Sourced from openFDA

Directions adults and children 12 years of age and over: take 1 tablet every 4 to 6 hours, not to exceed 6 tablets (24 mg) in 24 hours, or as directed by a doctor children under 12 years of age: consult a doctor

Warnings & precautions

Sourced from openFDA

Ask a doctor before use if you have a breathing problem such as emphysema or chronic bronchitis glaucoma difficulty in urination due to enlargement of the prostate gland

Approval history

Sourced from openFDA
  • Dec 19, 2002NDANDA021441Haleon Us Holdings
  • May 13, 2009ANDAANDA040829Avanthi Inc
  • Oct 1, 2010ANDAANDA091632Tris Pharma Inc
  • Dec 21, 2011NDANDA022113Haleon Us Holdings
  • Jun 22, 2015NDANDA206323Mainpointe

FAERS reports

View JSON
Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
64,565 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
  1. 1Drug Ineffective5,3918.3%
  2. 2Fatigue4,2286.5%
  3. 3Nausea3,9726.2%
  4. 4Headache3,7875.9%
  5. 5Dyspnoea3,7395.8%
  6. 6Diarrhoea3,2565.0%
  7. 7Pain2,8794.5%
  8. 8Off Label Use2,8164.4%
  9. 9Dizziness2,7584.3%
  10. 10Cough2,3363.6%
  11. 11Vomiting2,2933.6%
  12. 12Pneumonia2,1693.4%
  13. 13Anxiety1,9443.0%
  14. 14Pyrexia1,9333.0%
  15. 15Arthralgia1,9243.0%

Literature

View JSON

Recent PubMed references pinned to Chlorpheniramine as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

Clinical trials

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The 10 most recently updated of 59 ClinicalTrials.gov registrations naming Chlorpheniramine as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

Frequently asked questions

How does Chlorpheniramine work?
Mechanism-of-action class: Histamine H1 Receptor Antagonists.
What is Chlorpheniramine used for?
According to FDA labeling, Chlorpheniramine carries indications including: Uses temporarily relieves these symptoms due to hay fever (allergic rhinitis) or other upper respiratory allergies: sneezing runny nose itching of the nose or throat itchy, watery eyes. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
What class of drug is Chlorpheniramine?
Chlorpheniramine is classified as Substituted alkylamines, Histamine-1 Receptor Antagonist, Histamine H1 Receptor Antagonists, Decreased Histamine Activity.
What are the brand names for Chlorpheniramine?
Chlorpheniramine is marketed under brand names including Aller-Chlor, Chlor-Trimeton, Poly Hist PD, Tannic-12 S, Tussionex, Tuxarin, Tuzistra, Ventuss.
Note. Data for chlorpheniramine is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.

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