Citrulline

• USES: • For the temporary relief of the symptoms including: • circulation support • fatigue These statements are based upon homeopathic principles. They have not been reviewed by the Food and Drug Administration.

DIRECTIONS: 1-10 drops under the tongue, 3 times a day or as directed by a health professional. Consult a physician for use in children under 12 years of age.

If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. In case of overdose, contact a physician or Poison Control Center right away. Tamper Evident: Sealed for your protection. Do not use if seal is broken or missing.

1. 1Body Temperature Increased1100%
2. 2Inflammation1100%
3. 3Oedema1100%
4. 4Staphylococcal Infection1100%

Recent PubMed references pinned to Citrulline as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• L-citrulline modulates pancreatic enzyme activity and biochemical markers in adult female Wistar rats with metabolic syndrome.
  Pakistan journal of pharmaceutical sciences · 2026 · Imam Isa A, Eissa H, Abd-El Rahman MN, et al.
  PMID 42170986DOI 10.36721/PJPS.2026.39.7.209.1
• Impact of L-arginine and L-citrulline supplementation on macrophage responses to Mycobacterium tuberculosis.
  Frontiers in immunology · 2026 · Bhargavi G, Shreeram S, Prioult G, et al.
  PMID 42164505DOI 10.3389/fimmu.2026.1810985
• Chemical derivatization of citrullinated peptides using methylglyoxal and sodium 3-mercaptopropanesulfonate (MG/MPS).
  Analytical methods : advancing methods and applications · 2026 · Wang Y, Zhao J, Zhang S, et al.
  PMID 42148935DOI 10.1039/d6ay00547k
• Vascular effects of l-citrulline supplementation in healthy adults are largely influenced by the prehypertensive range of blood pressure: A double-blind, randomized, placebo-controlled, parallel-group study.
  Nutrition research (New York, N.Y.) · 2026 · Nogimura D, Nagaoka K, Ogino K, et al.
  PMID 42142423DOI 10.1016/j.nutres.2026.04.008
• Nanofiltration for Separation of L-Citrulline From Watermelon Rind Juice.
  Journal of food science · 2026 · Vi NT, Tran TMT, Lai QD, et al.
  PMID 42104553DOI 10.1111/1750-3841.71105
• Development of a generic physiologically based pharmacokinetic model to predict clinical pharmacokinetics and assess drug-drug interaction risks for valine-citrulline-monomethyl auristatin E-based antibody-drug conjugates.
  Drug metabolism and disposition: the biological fate of chemicals · 2026 · Shen C, Wang R, Yan J, et al.
  PMID 42066734DOI 10.1016/j.dmd.2026.100289
• Analysis of catabolic products of L-arginine; L-ornithine and L-citrulline and the residual L-arginine using the HPLC and LC-MS.
  PloS one · 2026 · Prashath S
  PMID 42030331DOI 10.1371/journal.pone.0346976
• Heat stress-mediated oxidative damage in male germ cells: potential protective effects of L-citrulline.
  Frontiers in endocrinology · 2026 · Qin Y, Wu H, Mo L, et al.
  PMID 41938116DOI 10.3389/fendo.2026.1800681

The 10 most recently updated of 157 ClinicalTrials.gov registrations naming Citrulline as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• L-Citrulline and Tadalafil for Mild to Moderate Erectile Dysfunction
  Recruiting · Phase 4 · Interventional · 133 enrolled · Beni-Suef University
  NCT07642505updated 2026-06-12
• L-Citrulline Versus Tamsulosin for Medical Expulsive Therapy of Distal Ureteral Stones
  Recruiting · Phase 2 · Interventional · 120 enrolled · Beni-Suef University
  NCT07617909updated 2026-06-01
• A Study of Becotatug Vedotin (MRG003) Combined With Epirubicin as Neoadjuvant Therapy for EGFR-Positive, Unresectable Recurrent Sinonasal Adenoid Cystic Carcinoma
  Recruiting · Phase 2 · Interventional · 40 enrolled · Eye & ENT Hospital of Fudan University
  NCT07522879updated 2026-05-12
• Safety and PK-PD Study of Oral L-CIT in Preterm Infants With BPD±PH and NEC
  Recruiting · Interventional · 36 enrolled · The Hospital for Sick Children
  NCT05636397updated 2026-05-04
• Novel Approaches for Improving Vascular Function in Veterans With HFpEF
  Recruiting · Phase 1 · Interventional · 90 enrolled · VA Office of Research and Development
  NCT06312748updated 2026-04-23
• Effect of a Non-pharmacological Intervention on Endothelial Function, Body Composition, and Physical Functionality in Recovered COVID-19 Patients.
  Completed · Interventional · 43 enrolled · Instituto Nacional de Enfermedades Respiratorias
  NCT07544186updated 2026-04-22
• Intravenous L-Citrulline for Vaso-occlusive Pain Episode in Sickle Cell Disease
  Recruiting · Phase 2 · Interventional · 99 enrolled · Suvankar Majumdar
  NCT06635902updated 2026-04-13
• EGFR-ADC (Becotatug Vedotin) Combined With PD-1 Inhibitor (Pucotenlimab) in Neoadjuvant Treatment of Advanced Penile Cancer
  Not yet recruiting · Phase 2 · Interventional · 60 enrolled · Jiyan Liu
  NCT07518979updated 2026-04-09
• Effect of Watermelon on Gut and Cardiometabolic Health
  Recruiting · Interventional · 36 enrolled · Florida State University
  NCT06588218updated 2026-04-09
• Effect of a Daily Supplement on Plasma PAI-1 Levels
  Recruiting · Phase 1 · Phase 2 · Interventional · 35 enrolled · University of California, Los Angeles
  NCT07469475updated 2026-03-13

Frequently asked questions

What is Citrulline used for?

According to FDA labeling, Citrulline carries indications including: USES: • For the temporary relief of the symptoms including: • circulation support • fatigue These statements are based upon homeopathic principles. They have not been reviewed by the Food and Drug Administration.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.