pharmacopeia
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/api/v1/drug/clotrimazole

Mechanism of action

Sourced from openFDA

Mechanism-of-action class: Squalene Monooxygenase Inhibitors.

Squalene Monooxygenase

Indications

Sourced from openFDA
  • Uses Cures athlete’s foot (tinea pedis), jock itch (tinea cruris), ringworm (tinea corporis). Relieves the itching, irritation, redness, scaling and discomfort which can accompany these conditions.ICD-10: B35.3

Dosage & administration

Sourced from openFDA

Directions • Wash the affected area and dry thoroughly. ● Apply a thin layer of this product over affected area twice daily (morning and night), or as directed by a doctor. ● Supervise children in the use of this product. ● For athlete’s foot, pay special attention to the spaces between the toes; wear well-fitting ventilated shoes, and change shoes and socks at least once daily. ● For athlete’s foot and ringworm, use daily for 4 weeks. For jock itch, use daily for 2 weeks. ● If conditions persists longer, consult a doctor. ● This product is not effective on the scalp or nails.

Warnings & precautions

Sourced from openFDA

For External use only.

Approval history

Sourced from openFDA
  • Jul 16, 1993ANDAANDA074165P And L
  • Aug 31, 1993ANDAANDA072640Sun Pharma Canada
  • Dec 4, 1995ANDAANDA072641Sun Pharma Canada
  • Jul 29, 1996ANDAANDA074580Sun Pharma Canada
  • Apr 12, 2000NDANDA021143Sun Pharma Canada
  • May 29, 2001ANDAANDA075673Taro
  • Jun 5, 2001ANDAANDA075502Fougera Pharms
  • Sep 26, 2025NDANDA217628Carwin Pharm Assoc

FAERS reports

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Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
12,471 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
  1. 1Drug Ineffective1,40611%
  2. 2Nausea8707.0%
  3. 3Pain8296.6%
  4. 4Macular Degeneration8056.5%
  5. 5Headache7686.2%
  6. 6Off Label Use7666.1%
  7. 7Dyspnoea7646.1%
  8. 8Fatigue7145.7%
  9. 9Diarrhoea6435.2%
  10. 10Pyrexia5534.4%
  11. 11Malaise5014.0%
  12. 12Rash4994.0%
  13. 13Weight Decreased4903.9%
  14. 14Anxiety4793.8%
  15. 15Chronic Kidney Disease4753.8%

Literature

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Recent PubMed references pinned to Clotrimazole as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

Clinical trials

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The 10 most recently updated of 146 ClinicalTrials.gov registrations naming Clotrimazole as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

Frequently asked questions

How does Clotrimazole work?
Mechanism-of-action class: Squalene Monooxygenase Inhibitors.
What is Clotrimazole used for?
According to FDA labeling, Clotrimazole carries indications including: Uses Cures athlete’s foot (tinea pedis), jock itch (tinea cruris), ringworm (tinea corporis). Relieves the itching, irritation, redness, scaling and discomfort which can accompany these conditions.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
What class of drug is Clotrimazole?
Clotrimazole is classified as Antiinfectives and antiseptics for local oral treatment, Imidazole and triazole derivatives, Imidazole derivatives, Azole Antifungal, Squalene Monooxygenase Inhibitors, Decreased Cell Wall Integrity.
What are the brand names for Clotrimazole?
Clotrimazole is marketed under brand names including Aardora Anti-Fungal Maximum Strength, Alevazol, Clotic, Cruex Antifungal, Dermatin, Fungicure Solution, Fungistat, Jock-Eze.
Note. Data for clotrimazole is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.

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