Clove Oil

Mechanism-of-action class: Immunologic Factor Interactions.

• Uses for the temporary relief of pain and to help prevent infection and promote healing of: canker sores cold sores fever blisters minor irritation, injury, cuts or other sores of the mouth and gums.ICD-10: B00.9

Directions Adults and children of any age, apply to the affected area as needed Children under 12 years of age should be supervised in the use of this product

Warnings

Recent PubMed references pinned to Clove Oil as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Nanostructured lipid carrier enabled delivery of levofloxacin and clove essential oil to overcome Pseudomonas aeruginosa biofilm infection in burn wounds- a synergistic approach.
  International journal of pharmaceutics · 2026 · Razdan K, Allott M, Kanta S, et al.
  PMID 42002056DOI 10.1016/j.ijpharm.2026.126885
• Histological effects of intranasal clove essential oil on the olfactory bulb in a rat model of depression.
  Tissue & cell · 2026 · Elfakharany W, Shafik MM, Amin MA, et al.
  PMID 41980326DOI 10.1016/j.tice.2026.103508
• Clove Essential Oil as an Antifungal Agent and Putative Dual-Action Antifungal Mechanism: Experimental Validation and Computational Insights into Orthosteric and Allosteric Modulation of Chitin Synthase I in Penicillium Species.
  Molecules (Basel, Switzerland) · 2026 · Castillo Y, Márquez Brazón EA, Peralta-Ruiz Y, et al.
  PMID 41976175DOI 10.3390/molecules31071132
• Keratinocytes biocompatibility, antibacterial and antioxidant properties of porous coacervate phosphate glass fibres and powders loaded with cerium and clove oil: a comparative study.
  Journal of materials chemistry. B · 2026 · Moghaddam Z, Sanwlani R, Nery ET, et al.
  PMID 41948876DOI 10.1039/d5tb02254a
• Freeze-Thaw-Induced Physically Cross-Linked Poly(Vinyl Alcohol)/Alginate Hydrogels Incorporating Silver-Doped Zinc Oxide and Clove Oil.
  Biopolymers · 2026 · Mutlu B
  PMID 41937417DOI 10.1002/bip.70098
• Enhanced preservation effects of clove essential oil-loaded chitosan/beta cyclodextrin metal organic frameworks (β-CD-MOFs) composite coating on cherry tomatoes.
  Journal of the science of food and agriculture · 2026 · Wang Y, Du YT, Yan WB, et al.
  PMID 41796041DOI 10.1002/jsfa.70561
• Immersion in clove oil with and without ethanol does not result in consistent anesthesia in mystery snails (Pomacea bridgesii).
  American journal of veterinary research · 2026 · Davidson A, Scagnelli A, Clarke L, et al.
  PMID 41791220DOI 10.2460/ajvr.26.01.0013
• Clove oil and selenium nanoparticles as eco-friendly antifungal agents for photographic preservation.
  Applied microbiology and biotechnology · 2026 · El-Sayed H, Osman ME, Ali N, et al.
  PMID 41721856DOI 10.1007/s00253-026-13730-3

The 10 most recently updated of 28 ClinicalTrials.gov registrations naming Clove Oil as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Impact of a Novel Functional Snack on Perimenopausal Symptoms and Well-being
  Recruiting · Interventional · 20 enrolled · King's College London
  NCT07599930updated 2026-05-20
• Evaluation Through Innovative Examinations of Intestinal Dysbiosis Status in Patients Diagnosed With Cardiovascular Diseases and Evaluation of the Efficacy of Natural and Probiotic Extracts in the Non-pharmacological Approach to Improving Intestinal Dysbiosis Status.
  Recruiting · Interventional · 15 enrolled · Casa di Cura Dott. Pederzoli
  NCT07429227updated 2026-02-24
• Chemosensory Dysfunction and Recovery in Endoscopic Endonasal Skull Base Surgery
  Completed · Interventional · 41 enrolled · Johns Hopkins University
  NCT05912881updated 2026-02-18
• EFFECTS OF CİTRUS AND CLOVE OİL AROMATHERAPY İN OLDER ADULTS
  Not yet recruiting · Interventional · 51 enrolled · Mersin University
  NCT07368374updated 2026-01-26
• The Combined Effect of the Mediterranean Diet and Intermittent Fasting on Hypertension
  Not yet recruiting · Interventional · 48 enrolled · Nadide Gizem Tarakci Filiz
  NCT07189637updated 2025-09-24
• Anosmia Rehabilitation in Patients Post Coronavirus Disease (COVID 19)
  Withdrawn · Phase 4 · Interventional · 0 enrolled · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
  NCT04374474updated 2025-08-01
• Olfactory Function and Delayed Neurocognitive Recovery
  Completed · Interventional · 131 enrolled · Shanghai 10th People's Hospital
  NCT03441074updated 2025-07-31
• Effectiveness of Coconut Oil Pulling With Clove Oil, Coconut Oil Pulling and Fluoride Mouthwash on Streptococcus Mutans Count in Children
  Not yet recruiting · Interventional · 105 enrolled · Cairo University
  NCT06902532updated 2025-04-04
• Effect of Clove Oil and Menthol Lozenges on Post-extubation Sore Throat
  Unknown · Early phase 1 · Interventional · 150 enrolled · Atlas University
  NCT06811051updated 2025-02-06
• The Effect of Olfactory Training in Patients With COVID-19 Induced Olfactory Dysfunction
  Recruiting · Interventional · 65 enrolled · Ditte Gertz Mogensen
  NCT05539560updated 2024-09-23

Frequently asked questions

How does Clove Oil work?

Mechanism-of-action class: Immunologic Factor Interactions.

What is Clove Oil used for?

According to FDA labeling, Clove Oil carries indications including: Uses for the temporary relief of pain and to help prevent infection and promote healing of: canker sores cold sores fever blisters minor irritation, injury, cuts or other sores of the mouth and gums.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Clove Oil?

Clove Oil is classified as Immunologic Factor Interactions, Cell-mediated Immunity, Increased Histamine Release, Increased IgG Production, Increased T Lymphocyte Activation.