pharmacopeia
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/api/v1/drug/collagenase

Mechanism of action

Sourced from openFDA

Mechanism-of-action class: Enzyme Activators.

Enzyme

Indications

Sourced from openFDA
  • Collagenase Santyl ◊ Ointment is indicated for debriding chronic dermal ulcers 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18 and severely burned areas.

Contraindications

Sourced from openFDA
  • Collagenase Santyl ◊ Ointment is contraindicated in patients who have shown local or systemic hypersensitivity to collagenase.contraindicated

Dosage & administration

Sourced from openFDA

Collagenase Santyl ◊ Ointment should be applied once daily (or more frequently if the dressing becomes soiled, as from incontinence). When clinically indicated, crosshatching thick eschar with a #10 blade allows Collagenase Santyl ◊ Ointment more surface contact with necrotic debris. It is also desirable to remove, with forceps and scissors, as much loosened detritus as can be done readily. Use Collagenase Santyl ◊ Ointment in the following manner: 1 - Prior to application the wound should be cleansed of debris and digested material by gently rubbing with a gauze pad saturated with normal saline solution, or with the desired cleansing agent compatible with Collagenase Santyl ◊ Ointment (See PRECAUTIONS ), followed by a normal saline solution rinse. 2 - Whenever infection is present, it is desirable to use an appropriate topical antibiotic powder. The antibiotic should be applied to the wound prior to the application of Collagenase Santyl ◊ Ointment. Should the infection not respond, therapy with Collagenase Santyl ◊ Ointment should be discontinued until remission of the infection. 3 - Collagenase Santyl ◊ Ointment may be applied directly to the wound or to a sterile gauze pad which is then applied to the wound and properly secured. 4 - Use of Collagenase Santyl ◊ Ointment should be terminated when debridement of necrotic tissue is complete and granulation tissue is well established.

Adverse reactions

Sourced from openFDA

No allergic sensitivity or toxic reactions have been noted in clinical use when used as directed. However, one case of systemic manifestations of hypersensitivity to collagenase in a patient treated for more than one year with a combination of collagenase and cortisone has been reported.

Overdosage

Sourced from openFDA

No systemic or local reaction attributed to overdose has been observed in clinical investigations and clinical use. If deemed necessary the enzyme may be inactivated by washing the area with povidone iodine.

Approval history

Sourced from openFDA
  • Jun 4, 1965BLABLA101995Smith And Nephew
  • Feb 2, 2010BLABLA125338Auxilium Pharms

FAERS reports

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Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
6,926 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
  1. 1Drug Ineffective1,47521%
  2. 2Contusion6769.8%
  3. 3Swelling5848.4%
  4. 4Pain5668.2%
  5. 5Penile Swelling4796.9%
  6. 6Fracture Of Penis4516.5%
  7. 7Penile Contusion4496.5%
  8. 8Injection Site Pain3224.6%
  9. 9Death3184.6%
  10. 10Penile Pain3114.5%
  11. 11Condition Aggravated2263.3%
  12. 12Inappropriate Schedule Of Product Administration2263.3%
  13. 13Pain In Extremity2233.2%
  14. 14Injection Site Swelling2133.1%
  15. 15Peyronie^s Disease2042.9%

Literature

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Recent PubMed references pinned to Collagenase as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

Clinical trials

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The 10 most recently updated of 140 ClinicalTrials.gov registrations naming Collagenase as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

Frequently asked questions

How does Collagenase work?
Mechanism-of-action class: Enzyme Activators.
What is Collagenase used for?
According to FDA labeling, Collagenase carries indications including: Collagenase Santyl ◊ Ointment is indicated for debriding chronic dermal ulcers 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18 and severely burned areas.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
What class of drug is Collagenase?
Collagenase is classified as Proteolytic enzymes, Collagen-specific Enzyme, Enzyme Activators, Dermatologic Activity Alteration.
What are the brand names for Collagenase?
Collagenase is marketed under brand names including Santyl.
What are the contraindications for Collagenase?
Collagenase labeling lists contraindications including: Collagenase Santyl ◊ Ointment is contraindicated in patients who have shown local or systemic hypersensitivity to collagenase.. Always consult the full prescribing information and a clinician.
Note. Data for collagenase is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.

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