Copper

• Use: For temporary relief of spasms, cramps. Calming effect.

Directions for Use: Place drops under tongue for 30 seconds. Adults 7 drops 3 times a day. Children 2-12 years, 7 drops 3 times a day. Under 2 years, consult your doctor. Use until symptoms are relieved or as directed by your health care provider.

Consult your health care provider if symptoms persist more than 5 days or worsen.

• Nov 15, 1984NDANDA018680Coopersurgical
• Dec 21, 1990NDANDA019785Shine
• Sep 3, 2020NDANDA213227Curium
• Feb 24, 2025NDANDA218201Sebela Womens Hlth
• Jan 12, 2026NDANDA211241Sentynl Theraps Inc

1. 1Device Expulsion11,09525%
2. 2Device Breakage11,05225%
3. 3Complication Of Device Removal9,90523%
4. 4Foreign Body In Reproductive Tract8,68320%
5. 5Complication Of Device Insertion8,34219%
6. 6Device Dislocation7,18716%
7. 7Pain5,78513%
8. 8Embedded Device4,41710%
9. 9Reproductive Complication Associated With Device3,5958.2%
10. 10Anxiety2,8866.6%
11. 11Injury Associated With Device2,7476.3%
12. 12Off Label Use2,7436.3%
13. 13Emotional Distress2,7016.2%
14. 14Pelvic Pain2,4625.6%
15. 15Procedural Pain2,4495.6%

Recent PubMed references pinned to Copper as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Copper-Regulated Modulation of the MdbZIP11-MdHAT5 Transcriptional Module Enhances ABA-Mediated Immunity in Apple.
  Molecular plant pathology · 2026 · Yu H, Yang Z, Zhou H, et al.
  PMID 42272218DOI 10.1111/mpp.70297
• Targeting mGluR1-Mediated Microglial ER Stress Mitigates Copper-Induced TBI Neuroinflammation.
  Molecular neurobiology · 2026 · Wang D, Zhou J, Zhou Z, et al.
  PMID 42258122DOI 10.1007/s12035-026-05958-x
• Low Zinc Ameliorated the Decrease in Intestinal Copper Level Induced by Low Dietary Copper: Involvement of SUMOylated-Mtf-1 and Mtf-1/Atp7a Pathway.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026 · Zhong CC, Yang H, Hogstrand C, et al.
  PMID 42257536DOI 10.1096/fj.202503413R
• Engineered pectin-coated copper oxide nanocarriers for controlled fungicide release: a mechanistic exploration of fungal pectinase-mediated delivery and its role in advancing sustainable agriculture.
  World journal of microbiology & biotechnology · 2026 · Monika, Naskar A, Shekhar S, et al.
  PMID 42252308DOI 10.1007/s11274-026-05006-9
• Swab-based colorimetric determination of tear lactate using lactate oxidase-copper hybrid nanoflowers.
  Mikrochimica acta · 2026 · To TNH, Dang TV, Kim MI, et al.
  PMID 42249227DOI 10.1007/s00604-026-08187-0
• Biogenic Cu-Fe bimetallic nanoparticles induce apoptosis and inhibit invasion in glioblastoma cells.
  Molecular biology reports · 2026 · Karagöz C, Çağlar Yıldırım Ö
  PMID 42240779DOI 10.1007/s11033-026-12090-5
• Synthesis, Characterization, and Antibacterial Properties of Silver, Copper, and Ag/Cu Bimetallic Nanoparticles Supported on Organically Modified Bentonite.
  ChemPlusChem · 2026 · Cherifi Z, Derdar H, Radi MA, et al.
  PMID 42237719DOI 10.1002/cplu.70187
• High prevalence of serum zinc and copper deficiencies in systemic sclerosis: a cross-sectional study.
  Rheumatology international · 2026 · Yılmaz E, Oğuz Kökoğlu E, Şenel AS, et al.
  PMID 42234184DOI 10.1007/s00296-026-06180-7

The 10 most recently updated of 417 ClinicalTrials.gov registrations naming Copper as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• NEPC Study: An Exploratory Safety and Efficacy Study With PSMA, SSTR2 and GRPR Targeted Radioligand Therapy in Metastatic Neuroendocrine Prostate Cancer.
  Active not recruiting · Phase 1 · Interventional · 31 enrolled · Novartis Pharmaceuticals
  NCT06379217updated 2026-06-10
• Y-90 Treatment Response Using Transarterial Radioembolization
  Recruiting · Phase 2 · Interventional · 30 enrolled · Thomas Jefferson University
  NCT07145801updated 2026-06-10
• Verbal Analgesia During Copper IUD Insertion After Cesarean Delivery
  Completed · Interventional · 88 enrolled · Cairo University
  NCT07326007updated 2026-06-10
• Nutrition Supplement for Cystic Fibrosis
  Not yet recruiting · Interventional · 60 enrolled · Ohio State University
  NCT07163078updated 2026-06-09
• An Investigational Scan (64Cu-Labeled M5A Antibody) in Combination With SOC Chemotherapy and Radiotherapy in Locally Advanced Rectal Cancer
  Active not recruiting · Early phase 1 · Interventional · 14 enrolled · City of Hope Medical Center
  NCT05245786updated 2026-06-08
• FIBERGRAFT Aeridyan Posterolateral Fusion Study
  Recruiting · Interventional · 316 enrolled · DePuy Synthes Products, Inc.
  NCT07059065updated 2026-06-05
• Disulfiram With Copper Gluconate and Liposomal Doxorubicin in Treatment-Refractory Sarcomas
  Recruiting · Phase 1 · Interventional · 24 enrolled · Case Comprehensive Cancer Center
  NCT05210374updated 2026-06-05
• Copper Cu 64 PSMA I&T PET Imaging in Men With Newly Diagnosed Prostate Cancer
  Recruiting · Phase 3 · Interventional · 439 enrolled · Curium US LLC
  NCT06235151updated 2026-06-04
• Effects of Copper Versus Levonorgestrel Intrauterine Devices on Mucosal Microbiota and Barrier Function Among Young African Women
  Not yet recruiting · Interventional · 120 enrolled · Seattle Children's Hospital
  NCT07627958updated 2026-06-04
• Exercise to Augment TMS in Those With Treatment Resistant Depression
  Completed · Interventional · 26 enrolled · Butler Hospital
  NCT05913401updated 2026-06-03

Frequently asked questions

What is Copper used for?

According to FDA labeling, Copper carries indications including: Use: For temporary relief of spasms, cramps. Calming effect.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Copper?

Copper is classified as Copper-containing Intrauterine Device, Decreased Embryonic Implantation, Decreased Sperm Motility, Inhibit Ovum Fertilization.

What are the brand names for Copper?

Copper is marketed under brand names including Miudella, ParaGard.