Creatine

• For temporary relief of flatulence associated with constipation.ICD-10: K59.00

DIRECTIONS: 10 drops orally, 3 times a day. Consult a physician for use in children under 12 years of age.

If pregnant or breast-feeding, ask a health care professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. Do not use if tamper evident seal is broken or missing. Store in cool, dry place.

Recent PubMed references pinned to Creatine as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• [Neuropsychiatric Effects of Creatine: What Does the Preclinical and Clinical Evidence Conclude?].
  Revista medica de Chile · 2026 · Abarca M, González A, Dosal I, et al.
  PMID 42257668DOI 10.4067/s0034-98872026000300430
• Creatine monohydrate modulates testicular morphology and SOD1/NFκB-p65 immunoexpression in streptozotocin-induced diabetic rats.
  Journal of molecular histology · 2026 · Freitas LTC, de Melo Júnior HP, Oliveira EL, et al.
  PMID 42213211DOI 10.1007/s10735-026-10831-1
• Creatine monohydrate for lean mass, strength, and bone density in postmenopausal women: a systematic review and meta-analysis.
  Journal of the International Society of Sports Nutrition · 2026 · Naddafha S, Antonio J, Kreider RB, et al.
  PMID 42141930DOI 10.1080/15502783.2026.2668435
• Multinuclear Solid-State NMR and NMR Crystallography of Solid Forms of Creatine and Creatinine.
  Molecular pharmaceutics · 2026 · Fleischer CH 3rd, Rash VK, Dowdell ZT, et al.
  PMID 42096280DOI 10.1021/acs.molpharmaceut.6c00077
• Single-Dose Creatine Reduces Sleep Deprivation-Induced Deterioration in Cognitive Performance.
  Nutrients · 2026 · Gordji-Nejad A, Matusch A, Hengstler L, et al.
  PMID 42075005DOI 10.3390/nu18081192
• Brain creatine, estradiol and neurocognitive complaints in perimenopausal women: an exploratory cross-sectional study.
  Neuroscience letters · 2026 · Ostojic SM, Ostojic J
  PMID 42061673DOI 10.1016/j.neulet.2026.138616
• Quantitative assessment of cardiac phosphocreatine metabolism under physiological and pharmacological stress using chemical exchange saturation transfer magnetic resonance imaging.
  Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2026 · Huang Q, Berberet C, Wahidi R, et al.
  PMID 42055288DOI 10.1016/j.jocmr.2026.102739
• Rougan Tongluo Decoction Initiates Neuroprotection Against Cerebral Ischemia by Activating the Endogenous SLC6A8-Creatine-EARS2 Mitochondrial Pathway.
  Mediators of inflammation · 2026 · Ou C, Bai ZP, Hu GH, et al.
  PMID 41999222DOI 10.1155/mi/4419137

The 10 most recently updated of 343 ClinicalTrials.gov registrations naming Creatine as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Creatine Supplementation and Resistance Training to Improve Sarcopenia Parameters in Patients With Prostate Cancer After Androgen Deprivation Therapy
  Recruiting · Interventional · 34 enrolled · University of Sao Paulo
  NCT07463092updated 2026-06-11
• Increased Dietary Protein Intake During GLP-1 Medication Use (in Middle-aged Women With Overweight/Obesity)
  Recruiting · Interventional · 75 enrolled · University of Texas at Austin
  NCT07480109updated 2026-06-09
• Resistance Exercise and Creatine in Colorectal Cancer
  Completed · Interventional · 27 enrolled · University of South Carolina
  NCT06420726updated 2026-06-05
• Creatine Supplementation During GLP-1a Therapy
  Recruiting · Interventional · 40 enrolled · University of Saskatchewan
  NCT07625202updated 2026-06-04
• Characterization of Dysmorphology in Subjects With Creatine Transporter Deficiency
  Recruiting · Observational · 19 enrolled · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  NCT05600946updated 2026-06-04
• Creatine Supplementation and Resistance Training to Preserve Muscle Mass and Attenuate Cancer Progression
  Recruiting · Phase 3 · Interventional · 200 enrolled · University of Utah
  NCT06112990updated 2026-06-03
• Acute Pharmacokinetics of Create Wellness Gummies in Healthy Adults
  Recruiting · Interventional · 16 enrolled · University of Oklahoma
  NCT07579455updated 2026-05-28
• Relevant Outcome Measures for Creatine Transporter Deficiency Patient
  Recruiting · Interventional · 197 enrolled · Hospices Civils de Lyon
  NCT06018519updated 2026-05-27
• Study of Bcl-2 Inhibitor Sonrotoclax (BGB-11417) in Participants With Mature B-Cell Malignancies
  Active not recruiting · Phase 1 · Interventional · 437 enrolled · BeOne Medicines
  NCT04277637updated 2026-05-22
• Creatine and Resistance Training in Older Adults With Mild Cognitive Impairment
  Recruiting · Interventional · 200 enrolled · Western University, Canada
  NCT06948149updated 2026-05-19

Frequently asked questions

What is Creatine used for?

According to FDA labeling, Creatine carries indications including: For temporary relief of flatulence associated with constipation.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.