Cupric Chloride

Mechanism-of-action class: Electrolyte Activity.

• Cupric chloride injection 0.4 mg/mL is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN). Administration helps to maintain copper serum levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.

• None known.contraindicated

Cupric Chloride Injection, USP 0.4 mg/mL contains 0.4 mg copper/mL and is administered intravenously only after dilution. The additive should be diluted in a volume of fluid not less than 100 mL. For the adult receiving TPN, the suggested additive dosage is 0.5 to 1.5 mg copper/day (1.25 to 3.75 mL/day). For pediatric patients, the suggested additive dosage is 20 mcg copper/kg/day (0.05 mL/kg/day). Infants weighing less than 1500 gm may have increased requirements because of their low body reserves and increased requirements for growth. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. (See PRECAUTIONS .)

Direct intramuscular or intravenous injection of Cupric chloride injection 0.4 mg/mL is contraindicated, as the acidic pH of the solution (2) may cause considerable tissue irritation. Liver and/or biliary tract dysfunction may require omission or reduction of copper and manganese doses because these elements are primarily eliminated in the bile. WARNING: This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum. Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration.

None known.

Copper toxicity can produce prostration, behavior change, diarrhea, progressive marasmus, hypotonia, photophobia and peripheral edema. Such symptoms have been reported with a serum copper level of 286 mcg/dl. Copper toxicity can also result in hemolysis and liver toxicity, including hepatic necrosis which may be fatal. D- penicillamine has been reported effective as an antidote.

• Jun 26, 1986NDANDA018960Hospira
• Oct 31, 2022ANDAANDA212071Exela Pharma
• Apr 30, 2024ANDAANDA217626Stira
• Apr 30, 2024ANDAANDA216113Somerset
• Jan 26, 2026ANDAANDA217287Amneal

1. 1Fatigue7210%
2. 2Off Label Use679.4%
3. 3Headache618.5%
4. 4Nausea588.1%
5. 5Pain588.1%
6. 6Diarrhoea578.0%
7. 7Drug Ineffective476.6%
8. 8Weight Decreased476.6%
9. 9Malaise405.6%
10. 10Abdominal Pain385.3%
11. 11Dizziness375.2%
12. 12Anaemia354.9%
13. 13Dyspnoea334.6%
14. 14Constipation304.2%
15. 15Urinary Tract Infection294.1%

Recent PubMed references pinned to Cupric Chloride as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Application of cupric or ferric ions as environmentally benign oxidants to the chloride leaching of platinum from spent reforming catalysts.
  Journal of environmental management · 2023 · Kazemi M, Hosseini MR, Zamaniyan A, et al.
  PMID 36963178DOI 10.1016/j.jenvman.2023.117768
• A combined radical and non-radical oxidation processes for efficient degradation of Acid Orange 7 in the homogeneous Cu(II)/PMS system: important role of chloride.
  Environmental science and pollution research international · 2021 · Huang Y, Jiang Q, Yu X, et al.
  PMID 33982257DOI 10.1007/s11356-021-14262-1
• Chronic tribasic copper chloride exposure induces rat liver damage by disrupting the mitophagy and apoptosis pathways.
  Ecotoxicology and environmental safety · 2021 · Yu W, Liao J, Yang F, et al.
  PMID 33550083DOI 10.1016/j.ecoenv.2021.111968
• A novel strategy to reduce the viscosity of cellulose-ionic liquid solution assisted by transition metal ions.
  Carbohydrate polymers · 2021 · Fan Z, Chen J, Sun S, et al.
  PMID 33483051DOI 10.1016/j.carbpol.2020.117535
• GK-2 Reduces Death of Cultured Granule Neurons in Cerebellum Induced by the Toxic Effects of Zinc Ions.
  Bulletin of experimental biology and medicine · 2020 · Stelmashook EV, Aleksandrova OP, Rogozin PD, et al.
  PMID 32146635DOI 10.1007/s10517-020-04734-8
• Calcium chloride enhances the delivery of exosomes.
  PloS one · 2019 · Kim H, Kang JY, Mun D, et al.
  PMID 31329632DOI 10.1371/journal.pone.0220036
• Effects of single and mixture exposure of cadmium and copper in apoptosis and immune related genes at transcriptional level on the midge Chironomus riparius Meigen (Diptera, Chironomidae).
  The Science of the total environment · 2019 · Martín-Folgar R, Martínez-Guitarte JL
  PMID 31071664DOI 10.1016/j.scitotenv.2019.04.364
• Involvement of SAPK/JNK Signaling Pathway in Copper Enhanced Zinc-Induced Neuronal Cell Death.
  Toxicological sciences : an official journal of the Society of Toxicology · 2019 · Tanaka KI, Shimoda M, Kasai M, et al.
  PMID 30768131DOI 10.1093/toxsci/kfz043

Frequently asked questions

How does Cupric Chloride work?

Mechanism-of-action class: Electrolyte Activity.

What is Cupric Chloride used for?

According to FDA labeling, Cupric Chloride carries indications including: Cupric chloride injection 0.4 mg/mL is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN). Administration helps to maintain copper serum levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Cupric Chloride?

Cupric Chloride is classified as Electrolyte Activity, Cellular Activity Alteration.

What are the contraindications for Cupric Chloride?

Cupric Chloride labeling lists contraindications including: None known.. Always consult the full prescribing information and a clinician.