Dibucaine
AmidesAnalgesics and anestheticsAnesthetics for topical useLocal anestheticsStandardized Chemical AllergenImmunologic Factor InteractionsSodium Channel InteractionsAntipruritic ActivityCell-mediated ImmunityDecreased Sensory-Somatic Nervous System Organized Electrical ActivityIncreased Histamine ReleaseUS-FDASourced from openFDA
GET
/api/v1/drug/dibucaineMechanism of action
Sourced from openFDAMechanism-of-action classes: Immunologic Factor Interactions; Sodium Channel Interactions.
Indications
Sourced from openFDA- Do not use in children under 2 years at age in or near the eyes
Dosage & administration
Sourced from openFDADirections adults and children 12 years and over: if possible, clean the affected area with mild soap and wann water and nnse thoroughly. Dry by patting or blotting withh toilet tissue or a soft cloth before applying. apply externally to the affected area up to 3 or 4 times daily children under 12 years of age: ask a doctor
Warnings & precautions
Sourced from openFDAWarninigs For External Use Only Allergy alert certain persons can develop allergic reactions to ingredients in this product. If the symptoms being treated does not subside or redness, irritation, swelling, bleeding or other symptoms develop or increase, discontinue use and ask a doctor.
FAERS reports
Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
115 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
- 1Back Pain1917%
- 2Drug Ineffective1917%
- 3Malaise1816%
- 4Nausea1614%
- 5Blood Pressure Increased1513%
- 6Crohn^s Disease1513%
- 7Anxiety1412%
- 8Blood Pressure Systolic Increased1412%
- 9Body Temperature Decreased1412%
- 10Diverticulitis1412%
- 11Inappropriate Schedule Of Product Administration1412%
- 12Dizziness1311%
- 13Pain1311%
- 14Seizure1311%
- 15Abdominal Pain1210%
Literature
Recent PubMed references pinned to Dibucaine as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- Tuberculostearic Acid Controls Mycobacterial Membrane Compartmentalization.mBio · 2023 · Prithviraj M, Kado T, Mayfield JA, et al.PMID 36976029DOI 10.1128/mbio.03396-22
- Lipschütz Ulcer: An Unusual Diagnosis that Should Not be Neglected.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2021 · Pereira DAG, Teixeira EPP, Lopes ACM, et al.PMID 34077985DOI 10.1055/s-0041-1729147
- A synchronous fluorescence spectrofluorometric method for the simultaneous determination of policresulen and cinchocaine hydrochloride in ointment and suppositories.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2021 · Salem H, Abdelaziz A, Atef A, et al.PMID 33744839DOI 10.1016/j.saa.2021.119648
- Identification of dibucaine derivatives as novel potent enterovirus 2C helicase inhibitors: In vitro, in vivo, and combination therapy study.European journal of medicinal chemistry · 2020 · Tang Q, Xu Z, Jin M, et al.PMID 32619885DOI 10.1016/j.ejmech.2020.112310
- Pre-clinical evaluation of new dibucaine formulations for preventive analgesia.Journal of liposome research · 2021 · Furlan B, de Melo BT, Papini JZB, et al.PMID 32567452DOI 10.1080/08982104.2020.1785494
- Phentolamine Reverses Epinephrine-Enhanced Skin Antinociception of Dibucaine in Rats.Anesthesia and analgesia · 2019 · Chou AK, Chiu CC, Chen YW, et al.PMID 31094809DOI 10.1213/ANE.0000000000003421
- Systemic allergic dermatitis after patch testing with cinchocaine (dibucaine) and topical corticosteroids.Contact dermatitis · 2019 · Alves da Silva C, Paulsen EPMID 30977131DOI 10.1111/cod.13290
- Cardiolipin and phosphatidylethanolamine role in dibucaine interaction with the mitochondrial membrane.Biochimica et biophysica acta. Biomembranes · 2019 · Lopes SC, Ivanova G, de Castro B, et al.PMID 30840858DOI 10.1016/j.bbamem.2019.02.011
Frequently asked questions
- How does Dibucaine work?
- Mechanism-of-action classes: Immunologic Factor Interactions; Sodium Channel Interactions.
- What is Dibucaine used for?
- According to FDA labeling, Dibucaine carries indications including: Do not use in children under 2 years at age in or near the eyes. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
- What class of drug is Dibucaine?
- Dibucaine is classified as Amides, Analgesics and anesthetics, Anesthetics for topical use, Local anesthetics, Standardized Chemical Allergen, Immunologic Factor Interactions, Sodium Channel Interactions, Antipruritic Activity, Cell-mediated Immunity, Decreased Sensory-Somatic Nervous System Organized Electrical Activity, Increased Histamine Release.
- What are the brand names for Dibucaine?
- Dibucaine is marketed under brand names including Nupercainal.
Note. Data for
dibucaine is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.