Diethylstilbestrol

Mechanism-of-action class: Estrogen Receptor Agonists.

• HOMEOPATHIC INDICATIONS: For the temporary relief of symptoms related to toxicity, such as headache, fatigue, body aches, and skin complaints.** **These statements are based upon traditional homeopathic principles. They have not been reviewed by the Food and Drug Administration.ICD-10: R51.9

DIRECTIONS: 1-10 drops under the tongue, 3 times a day or as directed by a health professional. Consult a physician for use in children under 12 years of age.

Keep out of reach of children. In case of overdose, contact physician or a Poison Control Center right away. If pregnant or breast-feeding, ask a health professional before use. Tamper seal: "Sealed for Your Protection." Do not use if seal is broken or missing.

Recent PubMed references pinned to Diethylstilbestrol as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Prenatal diethylstilbestrol exposure and risk of benign breast disease: The National Cancer Institute Diethylstilbestrol Follow-up Study.
  International journal of cancer · 2026 · Mitra PR, Bertrand KA, Pfeiffer RM, et al.
  PMID 41590827DOI 10.1002/ijc.70331
• Subtle morphological and molecular responses to low-dose diethylstilbestrol in the developing rat penis.
  Reproductive toxicology (Elmsford, N.Y.) · 2026 · Elmelund E, Berg M, Pedersen M, et al.
  PMID 41448338DOI 10.1016/j.reprotox.2025.109149
• Ultrasensitive electrochemiluminescent biosensing platform with dual-amplification and switchable channels for sequential monitoring of estrogens in animal-derived foods.
  Mikrochimica acta · 2025 · Wei F, Du H, Luo Y, et al.
  PMID 41437162DOI 10.1007/s00604-025-07751-4
• Highly sensitive detection of diethylstilbestrol based on a dual-mode membrane sensor of molecular imprinted nanozymes.
  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2026 · Zhou Y, Li N, Ming L, et al.
  PMID 41370915DOI 10.1016/j.saa.2025.127303
• Sexual behavior and sexual identity in female offspring of women exposed in utero to diethylstilbestrol (DES).
  Journal of developmental origins of health and disease · 2025 · Troisi R, Hatch EE, Bertrand K, et al.
  PMID 41208278DOI 10.1017/S2040174424000175
• An in utero exposure to the synthetic estrogen diethylstilbestrol affects the fat pad composition in post-natal mammary glands.
  Toxicological sciences : an official journal of the Society of Toxicology · 2026 · Tovar-Parra D, McDermott A, Cardot J, et al.
  PMID 41208031DOI 10.1093/toxsci/kfaf157
• Transcriptomic and physiological insights into Diethylstilbestrol toxicity in Phaeodactylum tricornutum.
  Aquatic toxicology (Amsterdam, Netherlands) · 2026 · Zhao DS, Liu XL, Chen YT, et al.
  PMID 41202338DOI 10.1016/j.aquatox.2025.107636
• Ultra-sensitive and rapid detection of diethylstilbestrol by constructing molecularly imprinted electrochemical sensor via hetero-interface engineering of Pt nanoparticles-decorated MXene/NH(2)-UiO-66.
  Food chemistry · 2025 · Zhang Y, Cao T, Bai B, et al.
  PMID 40876167DOI 10.1016/j.foodchem.2025.146061

The 7 most recently updated of 7 ClinicalTrials.gov registrations naming Diethylstilbestrol as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• A Phase III Study of Radium-223 Dichloride in Patients With Symptomatic Hormone Refractory Prostate Cancer With Skeletal Metastases
  Completed · Phase 3 · Interventional · 921 enrolled · Bayer
  NCT00699751updated 2026-02-23
• A Study of Pharmacodynamic and Genetic Parameters of Abira-DES Study Participants (NCT02217566) - Participants With Metastatic Castration-Resistant Prostate Cancer Treated With Abiraterone Acetate Following Unresponsive Treatment With Diethylstilbestrol
  Completed · Observational · 42 enrolled · Janssen-Cilag Farmaceutica Ltda.
  NCT04268628updated 2022-01-03
• Study of Abiraterone Acetate in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC), Chemo-Naive, Who Received a Prior Diethylstilbestrol Therapy
  Completed · Phase 2 · Interventional · 46 enrolled · Janssen Research & Development, LLC
  NCT02217566updated 2020-01-13
• Efficacy and Safety Evaluating Study to Compare Uritos® (Imidafenacin) and Urotol® (Tolterodine) for Treatment of Overactive Bladder.
  Completed · Phase 3 · Interventional · 300 enrolled · R-Pharm
  NCT03575702updated 2019-05-21
• Ibudilast in the Treatment of Patients With Chronic Migraine.
  Completed · Phase 1 · Interventional · 33 enrolled · Parisa Gazerani
  NCT01389193updated 2015-12-29
• Dexamethasone, Aspirin, and Diethylstilbestrol in Treating Patients With Locally Advanced or Metastatic Prostate Cancer
  Completed · Phase 3 · Interventional · 260 enrolled · St. Bartholomew's Hospital
  NCT00316927updated 2013-06-26
• Docetaxel and Diethylstilbestrol in the Treatment of Androgen Independent Prostate Cancer
  Completed · Phase 2 · Interventional · 30 enrolled · University of Washington
  NCT00136526updated 2013-05-09

Frequently asked questions

How does Diethylstilbestrol work?

Mechanism-of-action class: Estrogen Receptor Agonists.

What is Diethylstilbestrol used for?

According to FDA labeling, Diethylstilbestrol carries indications including: HOMEOPATHIC INDICATIONS: For the temporary relief of symptoms related to toxicity, such as headache, fatigue, body aches, and skin complaints.** **These statements are based upon traditional homeopathic principles. They have not been reviewed by the Food and Drug Administration.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Diethylstilbestrol?

Diethylstilbestrol is classified as Estrogens, Estrogens, combinations with other drugs, Synthetic estrogens, plain, Estrogen Receptor Agonists, Bone Formation Stimulation, Vaginal Function Alteration.