pharmacopeia
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/api/v1/drug/dimethyl-sulfoxide

Indications

Sourced from openFDA
  • RIMSO-50 ® (dimethyl sulfoxide) is indicated for the symptomatic relief of patients with interstitial cystitis. RIMSO-50 ® has not been approved as being safe and effective for any other indication.

Contraindications

Sourced from openFDA
  • None known.contraindicated

Dosage & administration

Sourced from openFDA

Instillation of 50 mL of RIMSO-50 ® (dimethyl sulfoxide) directly into the bladder may be accomplished by catheter or asepto syringe and allow to remain for 15 minutes. Application of an analgesic lubricant gel such as lidocaine jelly to the urethra is suggested prior to insertion of the catheter to avoid spasm. The medication is expelled by spontaneous voiding. It is recommended that the treatment be repeated every two weeks until maximum symptomatic relief is obtained. Thereafter, time intervals between therapy may be increased appropriately. Administration of oral analgesic medication or suppositories containing belladonna and opium prior to the instillation of RIMSO-50 ® can reduce bladder spasm. In patients with severe interstitial cystitis with very sensitive bladders, the initial treatment, and possibly the second and third (depending on patient response) should be done under anesthesia. (Saddle block has been suggested).

Warnings & precautions

Sourced from openFDA

Dimethyl sulfoxide can initiate the liberation of histamine and there has been occasional hypersensitivity reaction with topical administration of dimethyl sulfoxide. This hypersensitivity has been reported in one patients receiving intravesical RIMSO-50 ® . The physician should be cognizant of this possibility in prescribing RIMSO-50 ® . If anaphylactoid symptoms develop, appropriate therapy should be instituted.

Adverse reactions

Sourced from openFDA

A garlic-like taste may be noted by the patient within a few minutes after instillation of RIMSO-50 ® (dimethyl sulfoxide). This taste may last several hours and because of the presence of metabolites, an odor on the breath and skin may remain for 72 hours. Transient chemical cystitis has been noted following instillation of dimethyl sulfoxide. The patient may experience moderately severe discomfort on administration. Usually this becomes less prominent with repeated administration.

Overdosage

Sourced from openFDA

The oral LD 50 of dimethyl sulfoxide in the dog is greater than 10 gm/kg. It is improbable that this dosage level could be obtained with intravesical instillation of RIMSO-50 ® in the patient. In case of accidental oral ingestion, specific measures should be taken to induce emesis. Additional measures which may be considered are gastric lavage, activated charcoal and force diuresis.

Approval history

Sourced from openFDA
  • Apr 4, 1978NDANDA017788Mylan Institutional

FAERS reports

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Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
239 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
  1. 1Drug Ineffective5021%
  2. 2Headache4921%
  3. 3Nausea4921%
  4. 4Off Label Use4318%
  5. 5Abdominal Pain4218%
  6. 6Pyrexia4017%
  7. 7Pain3916%
  8. 8Dyspepsia2912%
  9. 9Constipation2812%
  10. 10Infusion Related Reaction2812%
  11. 11Malaise2812%
  12. 12Fatigue2711%
  13. 13Weight Decreased2711%
  14. 14Anaemia2611%
  15. 15Erythema2611%

Literature

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Recent PubMed references pinned to Dimethyl Sulfoxide as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

Clinical trials

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The 10 most recently updated of 87 ClinicalTrials.gov registrations naming Dimethyl Sulfoxide as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

Frequently asked questions

What is Dimethyl Sulfoxide used for?
According to FDA labeling, Dimethyl Sulfoxide carries indications including: RIMSO-50 ® (dimethyl sulfoxide) is indicated for the symptomatic relief of patients with interstitial cystitis. RIMSO-50 ® has not been approved as being safe and effective for any other indication.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
What class of drug is Dimethyl Sulfoxide?
Dimethyl Sulfoxide is classified as Other topical products for joint and muscular pain, Other urologicals.
What are the brand names for Dimethyl Sulfoxide?
Dimethyl Sulfoxide is marketed under brand names including Fungizyl, Rimso-50, Synotic.
What are the contraindications for Dimethyl Sulfoxide?
Dimethyl Sulfoxide labeling lists contraindications including: None known.. Always consult the full prescribing information and a clinician.
Note. Data for dimethyl-sulfoxide is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.

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