Diosmin

• Bruselix™ Bruising Tablets are formulated to provide nutritional support during the body’s natural recovery process. They may be helpful for individuals experiencing bruising due to minor injuries, surgical procedures, or sensitive skin.

• Do not use if you have a known allergy to any of the ingredients in Bruselix™ Bruising Tablets , including Arnica Montana or pineapple (Bromelain). Avoid use if you have an allergy to citrus or bioflavonoid components.contraindicated

Take one (1) Bruselix™ Bruising Tablets daily, or as directed by a licensed healthcare practitioner. Do not exceed recommended dose.

Arnica: May cause allergic reactions in sensitive individuals, especially if there is a history of ragweed allergies. Bromelain: May increase the risk of bleeding in individuals taking anticoagulants or antiplatelet medications. Discontinue use two weeks before surgery. Zinc and Vitamin C: Use cautiously in individuals with kidney disease or those prone to kidney stones. If you experience an allergic reaction or prolonged bleeding, discontinue use and seek medical attention immediately. For use on the order of a licensed healthcare practitioner. Call your doctor about side effects. To report side effects, call PureTek Corporation at 1-877-921-7873.

Adverse reactions associated with the use of Bruising Tablets may include mild gastrointestinal discomfort, nausea, or allergic reactions such as skin rash. In rare cases, more serious reactions, such as prolonged bleeding or hypersensitivity reactions (e.g., difficulty breathing, swelling), may occur. If you experience any serious adverse effects, discontinue use and seek medical attention immediately.

OVERDOSE: In the event of overdose, seek medical attention immediately. Symptoms of overdose may include gastrointestinal upset, nausea, or an increased risk of bleeding due to excess Bromelain.

Recent PubMed references pinned to Diosmin as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Daflon illuminates a novel avenue in treating acute toxoplasmosis: An experimental study.
  Veterinary parasitology · 2026 · El Skhawy N, Hassan AY, Hassan SA, et al.
  PMID 42068803DOI 10.1016/j.vetpar.2026.110788
• The Flavonoids Hesperidin and Diosmin: Adjuvant Therapy for Obesity.
  JPMA. The Journal of the Pakistan Medical Association · 2026 · Kalra S, Dhingra A, Verma SK, et al.
  PMID 41830372DOI 10.47391/JPMA.26-12
• Effectiveness of Conservative Treatment on Chronic Venous Disease Symptoms and Quality of Life in Patients with Type 2 Diabetes: Results from a Subanalysis of the VEIN STEP Observational Study.
  Vascular health and risk management · 2026 · Ulloa JH, Tazi Mezalek Z, González Ochoa AJ, et al.
  PMID 41767423DOI 10.2147/VHRM.S556035
• Modulation of Oxidative Stress, Inflammation, and Apoptosis and Restoration of Sirt1/Nrf2/HO-1 Signaling by Diosmin Protect Against Diabetes-Induced Testicular Damage in Rats.
  International journal of molecular sciences · 2026 · Aladaileh SH, Abukhalil MH, Alfwuaires MA, et al.
  PMID 41683695DOI 10.3390/ijms27031268
• Diosmin Alleviates Pain via Mechanisms Involving Acetylcholinesterase and TRPV1 Inhibition: An In Silico and In Vivo Study.
  Basic & clinical pharmacology & toxicology · 2026 · Al-Kabariti AY, Al-Najjar BO, Alsalem M, et al.
  PMID 41588572DOI 10.1111/bcpt.70199
• Clinical efficacy of sodium heptasaponin combined with diosmin in postoperative patients undergoing posterior open surgery for degenerative diseases of the spine: A retrospective study.
  Pakistan journal of pharmaceutical sciences · 2026 · Wu C, Zhou F, Luo S, et al.
  PMID 41546572DOI 10.36721/PJPS.2026.39.2.REG.14546.1
• Diosmin or Hesperidin? Comparison of Antioxidative Action of Two Venoactive Flavonoids in Type 1 Diabetic Rats.
  International journal of molecular sciences · 2025 · Borymska W, Borymski S, Zych M, et al.
  PMID 41373413DOI 10.3390/ijms262311252
• Renoprotective effect of diosmin against chlorpyrifos-induced kidney injury is mediated by the regulation of TLR4/HMGB1/NF-κB, PPAR-γ/SIRT1, and Bax/Bcl2 signals.
  Journal of molecular histology · 2025 · Althumairy D, Ismail MB, Zahra HA, et al.
  PMID 41361550DOI 10.1007/s10735-025-10660-8

The 10 most recently updated of 53 ClinicalTrials.gov registrations naming Diosmin as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Effects of a Dietary Supplement Composed of Diosmin, Hesperidin, Bromelain, and Ruscus Aculeatus on the Quality of Life in Subjects With Lower Limb Disorders Possibly Prodromal to Chronic Venous Disease
  Completed · Interventional · 80 enrolled · Ekalab S.r.l.
  NCT07185386updated 2026-05-22
• Effect of Diosmin/Hesperidin Combination on Platinum Compounds-Induced Nephropathy in Cancer Patients
  Recruiting · Phase 4 · Interventional · 100 enrolled · Beni-Suef University
  NCT07598214updated 2026-05-20
• EFFECT OF DAFLON (DIOSMIN AND HESPERIDIN) ON POST-OPERATIVE SEROMA FORMATION IN BREAST CANCER SURGERY''
  Completed · Phase 4 · Interventional · 190 enrolled · Ittefaq Hospital trust
  NCT07588828updated 2026-05-15
• A Phase III Clinical Trial Evaluating the Efficacy and Safety of TriThien Duoc Capsules in Grade II Internal Haemorrhoids Patients With Bleeding Compared to Diosmin.
  Completed · Phase 3 · Interventional · 172 enrolled · Hanoi Medical University
  NCT07369635updated 2026-01-27
• Clinical Trial of Aesculus Hippocastanum and Associations Versus Diosmina and Hesperidina in Chronic Venous Insuficiency
  Completed · Phase 4 · Interventional · 120 enrolled · Fundação Educacional Serra dos Órgãos
  NCT06579482updated 2026-01-07
• Comparing Diosmin-Hesperidin and Loratadine to Prevent Bone Pain From G-CSF in Patients With Blood Cancers
  Recruiting · Interventional · 88 enrolled · Alexandria University
  NCT07300735updated 2025-12-29
• Silymarin vs Hesperidin/Diosmin in Fibromyalgia
  Recruiting · Interventional · 90 enrolled · Ain Shams University
  NCT07293767updated 2025-12-19
• Study of Diosmin for the Treatment of Digital Ulcers in Systemic Sclerosis
  Recruiting · Interventional · 45 enrolled · Primus Pharmaceuticals
  NCT06256575updated 2025-12-04
• Glue Embolization vs Conservative Treatment for Pelvic Congestion Syndrome
  Recruiting · Interventional · 40 enrolled · Tanta University
  NCT06560294updated 2025-08-19
• Effects of Bioflavanoids on Vascular Wall Remodeling in Patients With Varicose Veins
  Active not recruiting · Interventional · 100 enrolled · Ryazan State Medical University
  NCT06367166updated 2025-07-23

Frequently asked questions

What is Diosmin used for?

According to FDA labeling, Diosmin carries indications including: Bruselix™ Bruising Tablets are formulated to provide nutritional support during the body’s natural recovery process. They may be helpful for individuals experiencing bruising due to minor injuries, surgical procedures, or sensitive skin.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Diosmin?

Diosmin is classified as Bioflavonoids.

What are the brand names for Diosmin?

Diosmin is marketed under brand names including Vasoflex D1.

What are the contraindications for Diosmin?

Diosmin labeling lists contraindications including: Do not use if you have a known allergy to any of the ingredients in Bruselix™ Bruising Tablets , including Arnica Montana or pineapple (Bromelain). Avoid use if you have an allergy to citrus or bioflavonoid components.. Always consult the full prescribing information and a clinician.