Ethanolamine

Mechanism-of-action class: Sclerosing Activity.

• ETHAMOLIN Injection is indicated for the treatment of patients with esophageal varices that have recently bled, to prevent rebleeding. ETHAMOLIN is not indicated for the treatment of patients with esophageal varices that have not bled.

• ETHAMOLIN Injection should not be administered to subjects with a known hypersensitivity to ethanolamine, oleic acid, or ethanolamine oleate.contraindicated

Local ETHAMOLIN Injection sclerotherapy of esophageal varices should be performed by physicians who are famillar with an acceptable technique. The usual intravenous dose is 1.5 to 5.0 mL per varix. The maximum dose per treatment session should not exceed 20 mL. Patients with significant liver dysfunction (Child Class C) or concomitant cardiopulmonary disease should usually receive less than the recommended maximum dose. Submucosal injections are not recommended as they reportedly are more likely to result in ulceration at the site of injection. To obliterate the varix, injections may be made at the time of the acute bleeding episode and then after one week, six weeks, three months, and six months, as indicated. Note: Parenteral drug products should be inspected visually for particulate matter and discoloration before administration whenever solution and container permit.

ETHAMOLlN Injection should be used in pregnant women only when clearly needed (see PRECAUTIONS). The practice of injecting varicosities of the leg with ETHAMOLlN Injection is not supported by adequately controlled clinical trials. Therefore, such use is not recommended.

The reported frequency of complications/adverse events per injection session was 13%. The most common complications were pleural effusion/infiltration (2.1%), esophageal ulcer (2.1 %), pyrexia (1.8%), retrosternal pain (1.6%), esophageal stricture (1.3%), and pneumonia (1.2%). Other adverse local esophageal reactions have also been reported at rates of 0.1 to 0.4%, including esophagitis, tearing of the esophagus, sloughing of the mucosa overlying the injected varix, ulceration, stricture, necrosis, periesophageal abscess and perforation (see PRECAUTIONS). These complications appear to be dependent upon the dose and the patient's clinical state. Bacteremia has been observed in patients following injection of esophageal varices with ETHAMOLlN. Pyrexia and retrosternal pain are not infrequently observed during the post-injection period. Fatal aspiration pneumonia has occurred in patients with esophageal varices who underwent ETHAMOLIN Injection Sclerotherapy (see PRECAUTIONS). Anaphylactic shock and acute renal failure with spontaneous recovery have occurred (see PRECAUTIONS). A case of disseminated intravascular coagulation has been reported. Spinal cord paralysis due to occlusion of the anterior spinal artery has been reported in one child eight hours after ETHAMOLIN sclerotherapy.

Pregnancy: (Teratogenic Effects: Pregnancy Category C) Animal reproduction studies have not been conducted with ETHAMOLlN Injection. It is also not known whether ETHAMOLIN Injection can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. ETHAMOLIN Injection should be given to a pregnant woman only if clearly needed.

Overdosage of ETHAMOLIN Injection can result in severe intramural necrosis of the esophagus. Complications resulting from such overdosage have resulted in death.

• Dec 22, 1988NDANDA019357Qol Medcl

1. 1Oesophageal Varices Haemorrhage528%
2. 2Portal Vein Thrombosis317%
3. 3Product Use In Unapproved Indication317%
4. 4Off Label Use211%
5. 5Abdominal Pain15.6%
6. 6Abdominal Pain Upper15.6%
7. 7Anaemia15.6%
8. 8Arterial Haemorrhage15.6%
9. 9Ascites15.6%
10. 10Cataract15.6%
11. 11Disseminated Intravascular Coagulation15.6%
12. 12Dry Eye15.6%
13. 13Essential Thrombocythaemia15.6%
14. 14Gastrointestinal Ischaemia15.6%
15. 15Haemorrhagic Ascites15.6%

Recent PubMed references pinned to Ethanolamine as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Novelties in the pragmatic management of anaphylaxis in pediatric age.
  European journal of pediatrics · 2026 · Marseglia GL, Tosca MA, Miraglia Del Giudice M, et al.
  PMID 42262574DOI 10.1007/s00431-026-07147-3
• Symptom Improvement with BDP/FF/G Fixed Triple Inhalation Powder in Moderate to Severe COPD Patients Uncontrolled with Dual Therapies: A Non-Interventional, Open-Label, Single-Arm, Prospective Study (RESPONSE Slovenia).
  COPD · 2026 · Harlander M, Šubic T, Eržen R, et al.
  PMID 42262307DOI 10.1080/15412555.2026.2681198
• Aerosol Delivery With a Vibrating Mesh Nebulizer Across Tidal Volume-Based Pediatric Invasive Ventilation Models: An In Vitro Evaluation.
  Critical care explorations · 2026 · Miura S, Igarashi Y, Shono K, et al.
  PMID 42255941DOI 10.1097/CCE.0000000000001430
• Anaphylaxis and Epinephrine Use in Pregnancy.
  The journal of allergy and clinical immunology. In practice · 2026 · Tanno LK, Ellis AK, Hossenbaccus L, et al.
  PMID 42250901DOI 10.1016/j.jaip.2026.04.016
• Rational design of a o-phosphoethanolamine-functionalized sheet-like nanozyme enables target-induced crosslinking for sensing Cr(3).
  Analytica chimica acta · 2026 · Tang X, Wang L, Bu Z, et al.
  PMID 42242805DOI 10.1016/j.aca.2026.345711
• Modelling cognitive outcomes in the UK Biobank: Education, noradrenaline and frontoparietal networks.
  PloS one · 2026 · Bravo-Merodio L, Olley-Williams JA, Russ D, et al.
  PMID 42241456DOI 10.1371/journal.pone.0350452
• Dandruff Is a Low-Grade Inflammatory Condition Featuring Hyperproliferative Keratinocytes, Interleukin-17-Producing T Cells, and N-Acyl Ethanolamines.
  Immunity, inflammation and disease · 2026 · Kendall AC, Mohamed K, Linley H, et al.
  PMID 42237451DOI 10.1002/iid3.70467
• Comparative Effectiveness and Safety of Three Oral Antihypertensive Therapies on Maternal and Infant Outcomes in a California Medicaid Population, 2016-2020.
  Pharmacoepidemiology and drug safety · 2026 · Psaras C, Delker E, Baer RJ, et al.
  PMID 42235946DOI 10.1002/pds.70406

The 10 most recently updated of 2,214 ClinicalTrials.gov registrations naming Ethanolamine as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Hot Flashes and Neurovascular Function in Women
  Recruiting · Interventional · 120 enrolled · Mayo Clinic
  NCT05193968updated 2026-06-12
• Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study
  Recruiting · Interventional · 200 enrolled · The Cleveland Clinic
  NCT07363343updated 2026-06-12
• Angiotensin 2 for AKI After OLT
  Active not recruiting · Phase 4 · Interventional · 30 enrolled · University of California, Los Angeles
  NCT04592744updated 2026-06-12
• Treating Exacerbations of Asthma With Oral Montelukast in Children
  Completed · Phase 2 · Interventional · 90 enrolled · Vanderbilt University Medical Center
  NCT05819541updated 2026-06-12
• Vasopressin and Epinephrine Versus Epinephrine Alone in Cardiac Arrest
  Completed · Phase 4 · Interventional · 2,416 enrolled · Hospices Civils de Lyon
  NCT00127907updated 2026-06-11
• Chest Tube-Delivered Bupivacaine to Decrease Postoperative Pain After Cardiac Surgery
  Not yet recruiting · Early phase 1 · Interventional · 60 enrolled · University of Calgary
  NCT07643506updated 2026-06-11
• A Study to Test if a Fixed-Dose Combination of Fluticasone Propionate/Albuterol Sulfate is Effective in Preventing Asthma Exacerbations
  Active not recruiting · Phase 3 · Interventional · 2,772 enrolled · Teva Branded Pharmaceutical Products R&D LLC
  NCT06052267updated 2026-06-11
• The Effect of NAC on Lung Function and CT Mucus Score
  Terminated · Phase 4 · Interventional · 4 enrolled · University of California, San Francisco
  NCT03822637updated 2026-06-11
• Effect of Push-Dose Adrenaline on Peri-intubation Hypotension During Rapid Sequence Intubation in the Emergency Department
  Not yet recruiting · Phase 4 · Interventional · 128 enrolled · Marmara University Pendik Training and Research Hospital
  NCT07620327updated 2026-06-10
• Buffered Versus Conventional Local Anesthesia for Pain and Anxiety Reduction in School-Aged Children With Pulpitis
  Recruiting · Interventional · 60 enrolled · Universidad Autonoma de San Luis Potosí
  NCT07638254updated 2026-06-10

Frequently asked questions

How does Ethanolamine work?

Mechanism-of-action class: Sclerosing Activity.

What is Ethanolamine used for?

According to FDA labeling, Ethanolamine carries indications including: ETHAMOLIN Injection is indicated for the treatment of patients with esophageal varices that have recently bled, to prevent rebleeding. ETHAMOLIN is not indicated for the treatment of patients with esophageal varices that have not bled.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Ethanolamine?

Ethanolamine is classified as Sclerosing Agent, Sclerosing Activity, Vascular Sclerosing Activity.

What are the contraindications for Ethanolamine?

Ethanolamine labeling lists contraindications including: ETHAMOLIN Injection should not be administered to subjects with a known hypersensitivity to ethanolamine, oleic acid, or ethanolamine oleate.. Always consult the full prescribing information and a clinician.