Fluoride Ion

• Use ■ aids in the prevention of dental cavities

Directions adults and children 2 years of age and older brush teeth thoroughly, preferably after each meal or at least twice a day, or as directed by a dentist or doctor children 2 to 6 years of age instruct children under 6 years of age in good brushing and rinsing habits (to minimize swallowing). Supervise children under 6 years as necessary and use a pea-sized amount until your child is capable of using without supervision. children under 2 years of age do not use unless directed by a dentist or doctor

Keep out of reach of children under 6 years of age . If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away.

1. 1No Adverse Event240%
2. 2Oral Mucosal Exfoliation240%
3. 3Drug Ineffective120%
4. 4Oral Discomfort120%
5. 5Paraesthesia Oral120%
6. 6Product Packaging Issue120%
7. 7Product Use Issue120%

Recent PubMed references pinned to Fluoride Ion as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Anhydrous stannous fluoride toothpaste in dentin hypersensitivity: clinician-assessed and patient-reported outcomes from two controlled trials.
  Clinical oral investigations · 2026 · Qiu J, Creeth JE, Mohammad A, et al.
  PMID 42262610DOI 10.1007/s00784-026-06942-4
• Spatiotemporal variability, driving factors, and potential human health risks of fluoride and nitrate in surface water and groundwater of a sandy desert lake basin, Northwest China.
  Journal of environmental sciences (China) · 2026 · Li X, Li M, Qu S, et al.
  PMID 42217873DOI 10.1016/j.jes.2025.12.022
• From tooth to gut: Proteomic evidence of systemic dysregulation in fluorosis.
  Ecotoxicology and environmental safety · 2026 · Pongsapipatana N, Gavila P, Khieota T, et al.
  PMID 42202465DOI 10.1016/j.ecoenv.2026.120310
• Integrated hydrochemical and health-risk assessment of fluoride and major ions in groundwater from hattar and gadoon industrial estates, pakistan.
  Environmental geochemistry and health · 2026 · Ahmad T, Qadir A, Khan MA, et al.
  PMID 42201498DOI 10.1007/s10653-026-03261-1
• Preservation-to-Precision in Severe Early Childhood Caries: A Narrative Review of Silver Diamine Fluoride-When "Buying Time" Must Not Become "Selling Time".
  International journal of environmental research and public health · 2026 · Baghdadi ZD
  PMID 42196748DOI 10.3390/ijerph23050656
• Morphological, Histochemical, and Proteomic Analysis of the Effects of Fluoride and Amoxicillin, with Calcium and Vitamin D Supplementation, on Dental Enamel Formation.
  Calcified tissue international · 2026 · Porto IM, da Silva AAS, Dos Santos JVA, et al.
  PMID 42184017DOI 10.1007/s00223-026-01548-0
• Melatonin alleviates fluoride-induced developmental neurotoxicity by restoring SIRT3/HIF-1α axis-mediated mitochondrial dysfunction and reversing energy metabolism reprogramming.
  Ecotoxicology and environmental safety · 2026 · Ma R, Wang C, Qin W, et al.
  PMID 42176635DOI 10.1016/j.ecoenv.2026.120301
• Ecotoxicological insights into fluoride pollution affecting soil, plant and human health.
  Ecotoxicology and environmental safety · 2026 · Farooqi ZUR, Karim A, Qadir AA, et al.
  PMID 42172710DOI 10.1016/j.ecoenv.2026.120295

The 10 most recently updated of 1,055 ClinicalTrials.gov registrations naming Fluoride Ion as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Stannous Fluoride Toothpaste for Reduction and Treatment of Gingivitis
  Completed · Interventional · 133 enrolled · Church & Dwight Company, Inc.
  NCT07640399updated 2026-06-10
• F-18 Sodium Fluoride PET/CT Guided Versus Ultrasound- Guided Intra-articular Injections in Chronic Low Backache
  Completed · Interventional · 40 enrolled · Post Graduate Institute of Medical Education and Research, Chandigarh
  NCT07632508updated 2026-06-08
• Oral-Spray Bacillus Spore Probiotic in Preventing and Supporting Treatment of Dental Caries in Children
  Recruiting · Interventional · 130 enrolled · Anabio R&D
  NCT07241052updated 2026-06-05
• Clinical Study to Evaluate Remineralization Using an in Situ Model.
  Not yet recruiting · Phase 3 · Interventional · 30 enrolled · Colgate Palmolive
  NCT07625670updated 2026-06-04
• Testing of Bevacizumab, Erlotinib, and Atezolizumab in Combination for Advanced-Stage Kidney Cancer
  Recruiting · Phase 2 · Interventional · 65 enrolled · National Cancer Institute (NCI)
  NCT04981509updated 2026-06-03
• Dry-Shield vs Rubber Dam During Fissure Sealant Placement
  Completed · Interventional · 30 enrolled · Suez Canal University
  NCT07622173updated 2026-06-03
• Evaluate the Efficacy of an Oral Health Behavioral Intervention in People With Diabetes
  Enrolling by invitation · Phase 4 · Interventional · 10,000 enrolled · Colgate Palmolive
  NCT07619729updated 2026-06-03
• The Effects of Sodium Fluoride and Chlorhexidine Use on Salivary IL-6 and Matrix Metalloproteinase Levels in Children With Active Caries
  Recruiting · Interventional · 80 enrolled · Gül Keskin
  NCT07609797updated 2026-06-02
• Effectiveness of Two Different Desensitizing Dental Varnishes
  Not yet recruiting · Interventional · 66 enrolled · Ivoclar Vivadent AG
  NCT07622043updated 2026-06-02
• Effect of Bioactive Restorative Materials on Secondary Caries Prevention
  Completed · Interventional · 120 enrolled · Jouf University
  NCT07619378updated 2026-06-02

Frequently asked questions

What is Fluoride Ion used for?

According to FDA labeling, Fluoride Ion carries indications including: Use ■ aids in the prevention of dental cavities. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.