pharmacopeia
GET
/api/v1/drug/fluticasone
2D structure
S-(fluoromethyl) (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carbothioate
SMILES C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)SCF)O)C)O)F)C)F
InChIKey MGNNYOODZCAHBA-GQKYHHCASA-N

Mechanism of action

Sourced from openFDA

Mechanism-of-action classes: Corticosteroid Hormone Receptor Agonists; Glucocorticoid Receptor Agonists.

Corticosteroid Hormone ReceptorGlucocorticoid Receptor

Indications

Sourced from openFDA
  • Uses Temporarily relieves these symptoms of hay fever or other upper respiratory allergies: nasal congestion itchy, watery eyes itchy nose runny nose sneezing

Dosage & administration

Sourced from openFDA

Directions read the Quick Start Guide for how to: prime the bottle use the spray clean the spray nozzle shake gently before each use use this product only once a day do not use more than directed ADULTS AND CHILDREN 12 YEARS OF AGE AND OLDER Week 1- use 2 sprays in each nostril once daily Week 2 through 6 months- use 1 or 2 sprays in each nostril once daily, as needed to treat your symptoms After 6 months of daily use – ask your doctor if you can keep using CHILDREN 4 TO 11 YEARS OF AGE the growth rate of some children may be slower while using this product. Children should use for the shortest amount of time necessary to achieve symptom relief. Talk to your child’s doctor if your child needs to use the spray for longer than two months a year. an adult should supervise use use 1 spray in each nostril once daily CHILDREN UNDER 4 YEARS OF AGE do not use

Warnings & precautions

Sourced from openFDA

Only for use in the nose. Do not spray into your eyes or mouth.

Approval history

Sourced from openFDA
  • Aug 24, 2000NDANDA021077Glaxo Grp Ltd
  • Sep 29, 2000NDANDA020833Glaxo Grp Ltd
  • May 14, 2004NDANDA021433Glaxo Grp Ltd
  • Jun 8, 2006NDANDA021254Glaxo Grp Ltd
  • Apr 27, 2007NDANDA022051Haleon Us Holdings
  • May 1, 2012NDANDA202236Mylan Speciality Lp
  • May 10, 2013NDANDA204275Glaxo Grp Ltd
  • Jul 23, 2014NDANDA205434Haleon Us Holdings

FAERS reports

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Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
265,942 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
  1. 1Dyspnoea32,26612%
  2. 2Drug Ineffective25,2809.5%
  3. 3Asthma17,7726.7%
  4. 4Cough16,7776.3%
  5. 5Fatigue13,7745.2%
  6. 6Pneumonia13,6055.1%
  7. 7Headache12,9154.9%
  8. 8Off Label Use11,2944.2%
  9. 9Nausea11,0824.2%
  10. 10Product Dose Omission Issue11,0504.2%
  11. 11Pain10,1143.8%
  12. 12Malaise10,0093.8%
  13. 13Wheezing9,5993.6%
  14. 14Diarrhoea9,0733.4%
  15. 15Dizziness9,0623.4%

Literature

View JSON

Recent PubMed references pinned to Fluticasone as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

Clinical trials

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The 10 most recently updated of 832 ClinicalTrials.gov registrations naming Fluticasone as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

Structural analogs

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Ranked by 2D fingerprint (Tanimoto) similarity over PubChem structures. Structural proximity only — not a claim of therapeutic equivalence.

Frequently asked questions

How does Fluticasone work?
Mechanism-of-action classes: Corticosteroid Hormone Receptor Agonists; Glucocorticoid Receptor Agonists.
What is Fluticasone used for?
According to FDA labeling, Fluticasone carries indications including: Uses Temporarily relieves these symptoms of hay fever or other upper respiratory allergies: nasal congestion itchy, watery eyes itchy nose runny nose sneezing. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
What class of drug is Fluticasone?
Fluticasone is classified as Corticosteroids, Corticosteroids, potent (group III), Glucocorticoids, Corticosteroid, Corticosteroid Hormone Receptor Agonists, Glucocorticoid Receptor Agonists, Decreased Capillary Permeability, Decreased Fibroblast Migration, Decreased Glucocorticoid Secretion, Decreased Lysosomal Function, Decreased Polymorphonuclear Leukocyte Migration, Decreased Protein Synthesis.
What are the brand names for Fluticasone?
Fluticasone is marketed under brand names including Advair, AirDuo, Aller-Flo, Armonair, Arnuity, Beser, Breo, Clarispray.
Note. Data for fluticasone is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.

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