pharmacopeia
GET
/api/v1/drug/ibuprofen
2D structure
2-[4-(2-methylpropyl)phenyl]propanoic acid
SMILES CC(C)CC1=CC=C(C=C1)C(C)C(=O)O
InChIKey HEFNNWSXXWATRW-UHFFFAOYSA-N

Mechanism of action

Sourced from openFDA

Mechanism-of-action class: Cyclooxygenase Inhibitors.

Cyclooxygenase

Indications

Sourced from openFDA
  • Uses temporarily relieves minor aches and pains due to: headache toothache backache menstrual cramps the common cold muscular aches minor pain of arthritis temporarily reduces feverICD-10: J00, R50.9, R51.9

Dosage & administration

Sourced from openFDA

Directions do not take more than directed the smallest effective dose should be used adults and children 12 years and over: take 1 tablet every 4 to 6 hours while symptoms persist if pain or fever does not respond to 1 tablet, 2 tablets may be used do not exceed 6 tablets in 24 hours, unless directed by a doctor children under 12 years: ask a doctor

Warnings & precautions

Sourced from openFDA

Allergy alert: Ibuprofen may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include: rash facial swelling asthma (wheezing) hives skin reddening shock blisters If an allergic reaction occurs, stop use and seek medical help right away. Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you: take more or for a longer time than directed take a blood thinning (anticoagulant) or steroid drug have had stomach ulcers or bleeding problems have 3 or more alcoholic drinks every day while using this product are age 60 or older take other drugs containing prescription or nonprescription NSAIDs [aspirin, ibuprofen, naproxen, or others] Heart attack and stroke warning: NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher if you use more than directed or for longer than directed.

Approval history

Sourced from openFDA
  • May 18, 1984NDANDA018989Haleon Us Holdings
  • Sep 19, 1989NDANDA019771Haleon Us Holdings
  • Apr 20, 1995NDANDA020402Haleon Us Holdings
  • Jun 16, 1995NDANDA020516Kenvue Brands
  • Jun 10, 1996NDANDA020603Kenvue Brands
  • Jun 27, 1996NDANDA020589Haleon Us Holdings
  • Dec 13, 1996NDANDA020267Haleon Us Holdings
  • Jan 30, 1998NDANDA020812Haleon Us Holdings

FAERS reports

View JSON
Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
279,646 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
  1. 1Drug Ineffective27,0919.7%
  2. 2Pain19,2766.9%
  3. 3Fatigue18,4976.6%
  4. 4Nausea17,9686.4%
  5. 5Headache16,3435.8%
  6. 6Arthralgia13,2634.7%
  7. 7Dyspnoea12,9384.6%
  8. 8Vomiting12,8484.6%
  9. 9Diarrhoea12,5454.5%
  10. 10Dizziness11,2704.0%
  11. 11Rash10,9963.9%
  12. 12Off Label Use10,8503.9%
  13. 13Pruritus9,7533.5%
  14. 14Pyrexia9,6823.5%
  15. 15Product Use In Unapproved Indication8,5093.0%

Literature

View JSON

Recent PubMed references pinned to Ibuprofen as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

Clinical trials

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The 10 most recently updated of 1,091 ClinicalTrials.gov registrations naming Ibuprofen as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

Pharmacogenomics

View JSON

CPIC-curated drug–gene pairs for Ibuprofen. Levels describe the strength of curated evidence and guideline status — never a recommendation to test or to adjust therapy.

Frequently asked questions

How does Ibuprofen work?
Mechanism-of-action class: Cyclooxygenase Inhibitors.
What is Ibuprofen used for?
According to FDA labeling, Ibuprofen carries indications including: Uses temporarily relieves minor aches and pains due to: headache toothache backache menstrual cramps the common cold muscular aches minor pain of arthritis temporarily reduces fever. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
What class of drug is Ibuprofen?
Ibuprofen is classified as Antiinflammatory preparations, non-steroids for topical use, Antiinflammatory products for vaginal administration, Other cardiac preparations, Other throat preparations, Propionic acid derivatives, Nonsteroidal Anti-inflammatory Drug, Cyclooxygenase Inhibitors, Decreased Platelet Activating Factor Production, Decreased Prostaglandin Production, Decreased Thromboxane Production.
What are the brand names for Ibuprofen?
Ibuprofen is marketed under brand names including Addaprin, Advil, Caldolor, Combogesic, Counteract IB, Duexis, Genpril, Ibu.
Note. Data for ibuprofen is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.

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