Interleukin-12

• Take 15 minutes before meals.

DIRECTIONS Take 15 minutes before meals. Adults and children 12 years and older 20 drops twice a day in a little water. Hold in the mouth for about 30 seconds then swallow. Children between 12 years and 6 years of age 10 drops twice a day in a little water. Hold in the mouth for about 30 seconds then swallow. Children under 6 years 5 drops twice a day in a glass of water.

Stop use and ask doctor if symptoms worsen or persist more than 3 days

1. 1Anaemia327%
2. 2Hypercalcaemia327%
3. 3Aspartate Aminotransferase Increased218%
4. 4Blood Creatinine Increased218%
5. 5Fatigue218%
6. 6Hyperkalaemia218%
7. 7Leukopenia218%
8. 8Lymphopenia218%
9. 9Nausea218%
10. 10Thrombocytopenia218%
11. 11Vomiting218%
12. 12Alanine Aminotransferase Increased19.1%
13. 13Atrial Fibrillation19.1%
14. 14Atrial Flutter19.1%
15. 15Blood Alkaline Phosphatase Increased19.1%

Recent PubMed references pinned to Interleukin-12 as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Local delivery of SBRT and IL-12 to murine PDAC tumors modulates hematopoiesis.
  Oncoimmunology · 2026 · Vrooman TG, Quarato ER, Hannon G, et al.
  PMID 42246474DOI 10.1080/2162402X.2026.2682058
• Reference intervals for plasma IFN-α, TNF-α, IL-12p70, and IFN-γ by flow cytometry in healthy adults from eastern China: a single-center study.
  Frontiers in immunology · 2026 · Liu Q, Zhang L, Jiao X, et al.
  PMID 42220527DOI 10.3389/fimmu.2026.1806685
• Polyphosphates Attenuate Interleukin-12 Production in Macrophages Infected With Legionella pneumophila.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026 · Vasilew K, Jayaraman A, Platten J, et al.
  PMID 42219888DOI 10.1096/fj.202502405RRR
• An Immune Model Incorporating NK Cells and IL-12 to Predict the Efficacy of the Initial Treatment Cycle of Efgartigimod in Generalized Myasthenia Gravis.
  Drug design, development and therapy · 2026 · Xin H, Zhong Y, Zhang M, et al.
  PMID 42182584DOI 10.2147/DDDT.S598742
• Immunocytokines based on IL-12 for cancer therapy: Enhancing efficacy and reducing toxicity.
  International review of cell and molecular biology · 2026 · Beloki U, Salaberry L, Covo-Vergara Á, et al.
  PMID 42161466DOI 10.1016/bs.ircmb.2025.03.003
• GSH-Responsive PBAE Polymers for IL-12 mRNA Delivery in Melanoma Immunotherapy.
  Investigative ophthalmology & visual science · 2026 · Bao X, Xu Z, Wang X, et al.
  PMID 42159437DOI 10.1167/iovs.67.5.57
• X-ray programmable interleukin-12 expression via a Ca(2+) signaling-gated nanoplasmid system for cancer immunotherapy.
  Biomaterials · 2026 · Zhu A, Liu J, Song Z, et al.
  PMID 42155176DOI 10.1016/j.biomaterials.2026.124308
• Systemic BCG administration induces transcription factor signature in CD4(+) T cells that cooperates with IL-12 signaling to drive antiviral Th1 differentiation.
  Vaccine · 2026 · Wang R, Zhao Y, Yang J, et al.
  PMID 42142526DOI 10.1016/j.vaccine.2026.128720

The 10 most recently updated of 259 ClinicalTrials.gov registrations naming Interleukin-12 as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Study of an AAV Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma
  Recruiting · Phase 1 · Phase 2 · Interventional · 68 enrolled · Trogenix ltd
  NCT07346144updated 2026-06-12
• PDS01ADC in Combination With Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects With Metastatic Colorectal Cancer, Intrahepatic Cholangiocarcinoma, or Metastatic Adrenocortical Carcinoma
  Recruiting · Phase 2 · Interventional · 70 enrolled · National Cancer Institute (NCI)
  NCT05286814updated 2026-06-10
• Intensive Locoregional Chemoimmunotherapy, Intradermal Autologous Alpha-DC1 Vaccines, and Systemic Pembrolizumab for Advanced-Stage Ovarian Cancer
  Not yet recruiting · Phase 2 · Interventional · 28 enrolled · Kalinski, Pawel, MD, PhD
  NCT07634094updated 2026-06-08
• Dexmedetomidine in the Treatment of Symptoms Of Acute Opioid Withdrawal
  Completed · Phase 1 · Phase 2 · Interventional · 225 enrolled · BioXcel Therapeutics Inc
  NCT04470050updated 2026-06-03
• Phase 3 Trial Evaluating the Safety & Efficacy of IMNN-001 Administered in Combination w/ Standard NACT & Adjuvant Chemotherapy in Newly Diagnosed Patients w/ Advanced EOC, Fallopian Tube or Primary Peritoneal Cancer
  Recruiting · Phase 3 · Interventional · 500 enrolled · Imunon
  NCT06915025updated 2026-06-02
• Phase II IMNN-001 (Also Known as GEN-1) on SLL With BEV and NACT, Newly Diagnosed Advanced Ovarian, Fallopian Tube or Primary Peritoneal Cancer
  Recruiting · Phase 1 · Phase 2 · Interventional · 30 enrolled · Imunon
  NCT05739981updated 2026-06-02
• A Phase I/II Study of PDS01ADC With Docetaxel and Abiraterone in Adults With Metastatic Castration Sensitive and PDS01ADC With Docetaxel in Castration Resistant Prostate Cancer
  Recruiting · Phase 1 · Phase 2 · Interventional · 86 enrolled · National Cancer Institute (NCI)
  NCT04633252updated 2026-05-27
• An Open-Label, Proof of Consent Study of Vorinostat for the Treatment of Mdoerate-to-Severe Crohn s Disease and Maintenance Therapy With Ustekinumab
  Recruiting · Phase 1 · Phase 2 · Interventional · 35 enrolled · National Institute of Allergy and Infectious Diseases (NIAID)
  NCT03167437updated 2026-05-22
• Pembrolizumab and Recombinant Interleukin-12 in Treating Patients With Solid Tumors
  Active not recruiting · Phase 1 · Interventional · 36 enrolled · National Cancer Institute (NCI)
  NCT03030378updated 2026-05-19
• Neoantigen-based Personalized DNA Vaccine in Patients With Newly Diagnosed, Unmethylated Glioblastoma
  Active not recruiting · Phase 1 · Interventional · 9 enrolled · Washington University School of Medicine
  NCT04015700updated 2026-05-07

Frequently asked questions

What is Interleukin-12 used for?

According to FDA labeling, Interleukin-12 carries indications including: Take 15 minutes before meals.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.