Intrinsic Factor

• Chromagen™ is a multivitamin/multimineral dietary supplement indicated for use in improving the nutritional status of patients with iron deficiency.ICD-10: E61.1

• Chromagen™ is contraindicated in patients with a known hypersensitivity to any of the ingredients.contraindicated

One softgel daily, or as directed by a physician.

Allergic sensitization has been reported following both oral and parenteral administration of folic acid.

1. 1Fatigue1717%
2. 2Anaemia1515%
3. 3Pain In Extremity1111%
4. 4Asthenia1010%
5. 5Nausea1010%
6. 6Pain1010%
7. 7Back Pain99.2%
8. 8Chest Pain99.2%
9. 9Diarrhoea99.2%
10. 10Dizziness99.2%
11. 11Dyspnoea99.2%
12. 12Economic Problem99.2%
13. 13Arthralgia88.2%
14. 14Anxiety77.1%
15. 15Drug Exposure During Pregnancy77.1%

Recent PubMed references pinned to Intrinsic Factor as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Evaluation of the Binding Affinity of Nitrosylcobalamin to Intrinsic Factor as a Predictive Model for Cobalamin Binding Protein Interactions: A Comparative Study with Hydroxocobalamin.
  Frontiers in bioscience (Elite edition) · 2025 · Sysel AM, Bauer JA
  PMID 40150986DOI 10.31083/FBE26810
• Transcriptomic integrity of human oocytes used in ARTs: technical and intrinsic factor effects.
  Human reproduction update · 2024 · Ducreux B, Patrat C, Trasler J, et al.
  PMID 37697674DOI 10.1093/humupd/dmad025
• A new Bayesian procedure for the estimation of the referees' decision thresholds and agreement. The case of professional handball refereeing.
  Psychology of sport and exercise · 2023 · Bruno G, Vicovaro M, Nucci M, et al.
  PMID 37665830DOI 10.1016/j.psychsport.2022.102347
• Development of a Sensitive ELISA for Gastric Intrinsic Factor and Detection of Intrinsic Factor Immunoreactivity in Human Serum.
  Nutrients · 2022 · Greibe E, Nexo E
  PMID 36235695DOI 10.3390/nu14194043
• A master surgical educator: the "intrinsic" factor of Dr. Paul Greig.
  HPB : the official journal of the International Hepato Pancreato Biliary Association · 2022 · Al-Adra DP, Barbas AS, Shah S, et al.
  PMID 36002362DOI 10.1016/j.hpb.2022.07.014
• Cubilin, the intrinsic factor-vitamin B12 receptor.
  Vitamins and hormones · 2022 · Kozyraki R, Verroust P, Cases O, et al.
  PMID 35337634DOI 10.1016/bs.vh.2022.01.005
• Extrinsic and Intrinsic Factors Regulating Juvenile Refractive Development and Eye Growth.
  Investigative ophthalmology & visual science · 2021 · Choi KY, Chan HH
  PMID 34797905DOI 10.1167/iovs.62.14.21
• Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7.
  Molecular cell · 2021 · Lilic M, Darst SA, Campbell EA, et al.
  PMID 34171296DOI 10.1016/j.molcel.2021.05.017

The 10 most recently updated of 78 ClinicalTrials.gov registrations naming Intrinsic Factor as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Pre- and Post-neuromusculoskeletal Injury Risk Evaluation for Return-to-Duty Enhancement
  Recruiting · Observational · 2,690 enrolled · Womack Army Medical Center
  NCT05111925updated 2026-06-03
• Rapid Recovery: Gut Microbiome Correction for PTSD
  Active not recruiting · Interventional · 140 enrolled · Uzhhorod National University
  NCT07623967updated 2026-06-03
• Rivaroxaban vs. Warfarin for Post Cardiac Surgery Atrial Fibrillation
  Completed · Phase 3 · Interventional · 100 enrolled · Massachusetts General Hospital
  NCT03702582updated 2026-05-19
• Effects of Spencer's Technique on Shoulder Function
  Completed · Interventional · 20 enrolled · Edward Via Virginia College of Osteopathic Medicine
  NCT06447493updated 2026-05-13
• Super-Resolution Ultrasound Microvascular Mapping for Non-Invasive Breast Cancer Molecular Subtyping: A Validated Nomogram
  Completed · Observational · 94 enrolled · Anhui Provincial Cancer Hospital
  NCT07581054updated 2026-05-12
• Safety and Preliminary Efficacy of Pumitamig (BNT327), an Investigational Therapy for Patients With Non-small Cell Lung Cancer in Combination With Chemotherapy as First-line or Second-line Treatment
  Recruiting · Phase 2 · Interventional · 60 enrolled · BioNTech SE
  NCT06841055updated 2026-04-24
• Release Kinetics of rhBMP-2 Using E-PRF as an Autologous Carrier: An In Vitro Analysis
  Not yet recruiting · Observational · 20 enrolled · University of Alabama at Birmingham
  NCT04670965updated 2026-04-20
• Preventive Strategies for Early and Late Complications of Leptospirosis
  Recruiting · Phase 2 · Interventional · 678 enrolled · National Kidney and Transplant Institute, Philippines
  NCT07127718updated 2026-04-13
• Atezolizumab and Bevacizumab in Combination With Y^90 Radioembolization in HCC for Liver Transplant
  Recruiting · Phase 4 · Interventional · 40 enrolled · Icahn School of Medicine at Mount Sinai
  NCT07059494updated 2026-03-23
• Modified and Context-Focused Sports Intervention in Adolescents With Autism: Study Protocol
  Recruiting · Interventional · 52 enrolled · Federal University of Minas Gerais
  NCT06916988updated 2026-03-13

Frequently asked questions

What is Intrinsic Factor used for?

According to FDA labeling, Intrinsic Factor carries indications including: Chromagen™ is a multivitamin/multimineral dietary supplement indicated for use in improving the nutritional status of patients with iron deficiency.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What are the contraindications for Intrinsic Factor?

Intrinsic Factor labeling lists contraindications including: Chromagen™ is contraindicated in patients with a known hypersensitivity to any of the ingredients.. Always consult the full prescribing information and a clinician.