Ipratropium
GET
/api/v1/drug/ipratropium2D structure
[(1R,5S)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate
SMILES CC(C)[N+]1([C@@H]2CC[C@H]1CC(C2)OC(=O)C(CO)C3=CC=CC=C3)C
InChIKey OEXHQOGQTVQTAT-BZQJJPTISA-N
Mechanism of action
Sourced from openFDAMechanism-of-action classes: Cholinergic Antagonists; Cholinergic Muscarinic Antagonists.
CholinergicCholinergic Muscarinic
Approval history
Sourced from openFDA- Jan 26, 2001ANDAANDA075693Ritedose Corp
- Sep 27, 2001ANDAANDA075562Nephron
- Mar 31, 2003ANDAANDA076025Bausch
- Mar 31, 2003ANDAANDA076103Bausch
- Apr 18, 2003ANDAANDA076155Apotex Inc
- Apr 18, 2003ANDAANDA076156Apotex Inc
- Nov 17, 2004NDANDA021527Boehringer Ingelheim
- Oct 7, 2011NDANDA021747Boehringer Ingelheim
FAERS reports
Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
38,836 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
- 1Dyspnoea6,58517%
- 2Asthma4,14111%
- 3Pneumonia3,3628.7%
- 4Cough3,2258.3%
- 5Drug Ineffective2,9497.6%
- 6Wheezing2,7467.1%
- 7Fatigue2,4266.2%
- 8Nausea2,1335.5%
- 9Chronic Obstructive Pulmonary Disease1,9725.1%
- 10Off Label Use1,9525.0%
- 11Malaise1,8154.7%
- 12Diarrhoea1,8024.6%
- 13Headache1,7944.6%
- 14Vomiting1,7424.5%
- 15Dizziness1,6254.2%
Literature
Recent PubMed references pinned to Ipratropium as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- Ipratropium bromide nebulization plus SOM: Protective effects in severe pneumonia with respiratory failure.Pakistan journal of pharmaceutical sciences · 2026 · Fang X, Zhang F, Wu T, et al.PMID 42170974DOI 10.36721/PJPS.2026.39.7.197.1
- More lessons from the Lung Health Study.American journal of epidemiology · 2026 · Holbrook JTPMID 41527371DOI 10.1093/aje/kwag004
- Predictive Value of Ipratropium Responsiveness on Posterior Nasal Nerve Neurectomy Outcomes in Chronic Rhinitis.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026 · Maddineni S, Hwang PH, Ayoub NF, et al.PMID 41474181DOI 10.1002/ohn.70099
- Eco-friendly cucurbituril-based potentiometric sensors for selective quantification of ipratropium bromide in pharmaceuticals and human plasma.Analytical and bioanalytical chemistry · 2026 · Tawfik SA, Mahmoud AM, Soudi AT, et al.PMID 41430000DOI 10.1007/s00216-025-06265-5
- Use of inhaled/nebulised ipratropium bromide in addition to standard first-line treatment with inhaled/nebulised short-acting beta 2-agonist and systemic steroid in the management of acute asthma exacerbations: a systematic review and meta-analysis of randomised controlled trials.Archives of disease in childhood · 2026 · Hamud AA, Mudawi K, Powell C, et al.PMID 41224524DOI 10.1136/archdischild-2024-327898
- Efficacy and safety of combined nebulization of unfractionated heparin, acetylcysteine, budesonide and ipratropium bromide in hospitalised patients with COVID-19 pneumonia: a randomized controlled clinical trial.BMC pulmonary medicine · 2025 · Gong J, Nie N, Jiang M, et al.PMID 40696325DOI 10.1186/s12890-025-03824-5
- [Unfounded objections against the use of salbutamol/ipratropium].Nederlands tijdschrift voor geneeskunde · 2025 · Lucassen EA, Rood R, Tibboel J, et al.PMID 40673353
- Evaluation of Respirable Fraction by using Next Generation Impactor of Levosalbutamol Sulphate and Ipratropium bromide Metered Dose Inhaler.Current drug research reviews · 2026 · Chilka C, Dhalani JPMID 40108911DOI 10.2174/0125899775352741250309005146
Clinical trials
The 10 most recently updated of 172 ClinicalTrials.gov registrations naming Ipratropium as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.
- Effect of Ipratropium Bromide on EILONot yet recruiting · Phase 2 · Interventional · 50 enrolled · Cook Children's Health Care SystemNCT07394036updated 2026-05-05
- Treating Respiratory Emergencies in Children StudyCompleted · Phase 2 · Interventional · 44 enrolled · Oregon Health and Science UniversityNCT06074185updated 2026-04-24
- Defining and Treating Depression-related AsthmaCompleted · Early phase 1 · Interventional · 39 enrolled · State University of New York at BuffaloNCT04617015updated 2026-04-23
- Magnesium Trial in Acute Asthma in Emergency DepartmentRecruiting · Phase 3 · Interventional · 192 enrolled · Suzanne SchuhNCT06785272updated 2025-12-18
- Functional Strength Training and Neuromuscular Electrical Stimulation in Severe Acute Exacerbations of COPDTerminated · Interventional · 35 enrolled · Hasselt UniversityNCT05480566updated 2025-09-15
- Revefenacin in Acute Respiratory Insufficiency in COPDCompleted · Phase 2 · Interventional · 21 enrolled · University of California, Los AngelesNCT04315558updated 2025-08-13
- Nebulized Ketamine Plus Standard Care vs. Standard Care Alone in Moderate to Severe Asthma ExacerbationsNot yet recruiting · Phase 2 · Interventional · 100 enrolled · Oman Medical Speciality BoardNCT07112456updated 2025-08-08
- The Effect of Nebulized Epinephrine in Asthma Exacerbation in Pediatric Age Group With the Standard Treatment Compared to Standard Treatment Using Improvement PRAM Score as a Primary OutcomeCompleted · Phase 4 · Interventional · 30 enrolled · Oman Medical Speciality BoardNCT05667727updated 2025-06-06
- Neural Respiratory Drive of Patients With Chronic Obstructive Pulmonary DiseaseCompleted · Interventional · 44 enrolled · The First Affiliated Hospital of Guangzhou Medical UniversityNCT05786950updated 2025-05-07
- A Comparative Study of Adding Ipratropium to Salbutamol for the Treatment of Asthma Attack in ChildrenCompleted · Phase 4 · Interventional · 60 enrolled · Children's Hospital and Institute of Child Health, MultanNCT06918418updated 2025-04-09
Frequently asked questions
- How does Ipratropium work?
- Mechanism-of-action classes: Cholinergic Antagonists; Cholinergic Muscarinic Antagonists.
- What class of drug is Ipratropium?
- Ipratropium is classified as Anticholinergic, Cholinergic Antagonists, Cholinergic Muscarinic Antagonists, Bronchodilation, Decreased Parasympathetic Acetylcholine Activity.
- What are the brand names for Ipratropium?
- Ipratropium is marketed under brand names including Atrovent, Combivent.
Note. Data for
ipratropium is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.