Lead
US-FDASourced from openFDA
GET
/api/v1/drug/leadIndications
Sourced from openFDA- Abdominal pain with constipation*ICD-10: K59.00
Dosage & administration
Sourced from openFDAAdults and children: At the onset of symptoms, dissolve 5 pellets under the tongue 3 times a day until symptoms are relieved or as directed by a doctor.
FAERS reports
Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
541 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
- 1Diarrhoea427.8%
- 2Headache407.4%
- 3Pain387.0%
- 4Arthralgia325.9%
- 5Fatigue325.9%
- 6Nausea305.5%
- 7Dizziness285.2%
- 8Pain In Extremity244.4%
- 9Asthenia224.1%
- 10Dyspnoea203.7%
- 11Malaise203.7%
- 12Constipation193.5%
- 13Fall193.5%
- 14Abdominal Pain Upper183.3%
- 15Depression183.3%
Literature
Recent PubMed references pinned to Lead as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- Distinct and indispensable roles of cell viability and extracellular polymeric substances in Pb mineralization by Sinorhizobium sp. C10.Biodegradation · 2026 · Gao Q, Zhao Y, Jia D, et al.PMID 42260190DOI 10.1007/s10532-026-10319-5
- Lead concentration in follicular fluid of infertile patients with and without endometriosis: a propensity score matching exploratory study.Frontiers in endocrinology · 2026 · Iavarone I, Mele D, Caprio F, et al.PMID 42255417DOI 10.3389/fendo.2026.1814365
- Adapting, piloting, and evaluating a pediatric lead screening and risk-reduction intervention in Nairobi: A hybrid implementation-effectiveness trial protocol.PloS one · 2026 · Onoh I, Mugo C, Riederer A, et al.PMID 42241430DOI 10.1371/journal.pone.0349153
- Exogenous pipecolic acid ameliorates lead-induced phytotoxicity in chili (Capsicum annuum L.) by enhancing antioxidant capacity and physiological homeostasis.Plant signaling & behavior · 2026 · Iqbal R, Mehmood H, Majeed A, et al.PMID 42226624DOI 10.1080/15592324.2026.2682037
- Modified and activated clinoptilolites ameliorate the cadmium and lead-induced genotoxicity in eukaryotic cells.Environmental geochemistry and health · 2026 · Todorova T, Boyadzhiev K, Kulekova S, et al.PMID 42223729DOI 10.1007/s10653-026-03274-w
- Multi-tissue contamination (mercury, lead, and organochlorine pesticides) and health biomarkers in Northern Shoveler and Northern Pintail during wintering.Environmental management · 2026 · Roos-Muñoz S, Cruz-Acevedo E, Castillo-Guerrero JA, et al.PMID 42218342DOI 10.1007/s00267-026-02504-2
- Interface behavior of brown soil under freeze-thaw action: Activated the adsorption sites and increased the resistance to desorption for Pb(2).Journal of environmental sciences (China) · 2026 · Yu W, Wang L, Mu X, et al.PMID 42217898DOI 10.1016/j.jes.2025.10.006
- Dual regulatory effects of sludge-derived biochar synergized with Priestia megaterium on soil phosphorus activation and lead mineralization.Journal of environmental sciences (China) · 2026 · Du J, Lv N, Dong B, et al.PMID 42217886DOI 10.1016/j.jes.2025.09.024
Clinical trials
The 10 most recently updated of 5,078 ClinicalTrials.gov registrations naming Lead as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.
- Posterosuperior Bundle Pacing for Prevention of Atrial Fibrillation in Patients With Sinus Node DysfunctionNot yet recruiting · Interventional · 300 enrolled · Shanghai Tong Ren HospitalNCT07645066updated 2026-06-12
- Development and Test of a Communication Skills Training for Transplant Providers - Aims 2 & 3Not yet recruiting · Interventional · 70 enrolled · Temple UniversityNCT06182475updated 2026-06-12
- Behavior Therapy for Irritability in AutismCompleted · Interventional · 65 enrolled · Yale UniversityNCT04654260updated 2026-06-12
- Synchronous vs Asynchronous Remotely Delivered Lifestyle InterventionsActive not recruiting · Interventional · 328 enrolled · University of ConnecticutNCT06393725updated 2026-06-12
- E-cigarette Cessation in Adults Who Co-use CannabisRecruiting · Phase 4 · Interventional · 105 enrolled · Medical University of South CarolinaNCT06688539updated 2026-06-12
- Self-Hypnosis Training for Migraine Management (HYlaMI): A Pilot and Proof-of-Concept StudyNot yet recruiting · Interventional · 40 enrolled · Ciusss de L'Est de l'Île de MontréalNCT07644299updated 2026-06-12
- Cuneiform Nucleus (CnF) Deep Brain Stimulation for Gait Facilitation Following Spinal Cord InjuryRecruiting · Interventional · 6 enrolled · University of MiamiNCT07109804updated 2026-06-12
- A Large-scale, Prospective Cohort Study Was Conducted to Explore the Association Between Environmental Exposure and Behavioral Factors and Infertility (the Success Rate of Assisted Reproductive Technology)Recruiting · Interventional · 5,000 enrolled · The Third Xiangya Hospital of Central South UniversityNCT07641387updated 2026-06-11
- A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal CancerActive not recruiting · Phase 3 · Interventional · 841 enrolled · PfizerNCT04607421updated 2026-06-11
- Prediction of Atrial Fibrillation Using Polygenic Risk ScoreRecruiting · Interventional · 800 enrolled · Seoul St. Mary's HospitalNCT07641582updated 2026-06-11
Frequently asked questions
- What is Lead used for?
- According to FDA labeling, Lead carries indications including: Abdominal pain with constipation*. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
Note. Data for
lead is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.