Leptin

• Food cravings, great appetite, regurgitation of food, nausea, eating relieves discomfort, constant belching, bloating, sluggish, overweight.ICD-10: R11.2

DIRECTIONS: 5 drops orally, 2 to 3 times per day. Take for 5 days, stop for 2 days, then repeat until you see symptoms abate. Consult a physician for use in children under 12 years of age.

If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. Do not use if tamper evident seal is broken or missing. Store in a cool, dry place.

1. 1Dizziness133%
2. 2Drug Dose Omission133%
3. 3Foot Fracture133%
4. 4Headache133%
5. 5Hyperglycaemia133%
6. 6Hypersensitivity133%
7. 7Hypoglycaemia133%
8. 8Insulin Resistance133%
9. 9Malaise133%
10. 10Nasopharyngitis133%
11. 11Nausea133%
12. 12Vomiting133%

Recent PubMed references pinned to Leptin as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• The RASA2/RASA3 ortholog RasGAP1 modulates obesity-linked phenotypes and is associated with leptin-analog signaling in Drosophila.
  Frontiers in endocrinology · 2026 · Moulin TC, Williams MJ, Schiöth HB, et al.
  PMID 42244947DOI 10.3389/fendo.2026.1773383
• Leptin in Obesity-Related Heart Failure: Pathophysiological Mechanisms and Therapeutic Implications.
  Comprehensive Physiology · 2026 · Li X, Wang W, Zhang Y, et al.
  PMID 42226483DOI 10.1002/cph4.70189
• Case Report: Twenty years of metreleptin therapy in congenital generalized lipodystrophy type 1: the longest reported follow-up to date.
  Frontiers in endocrinology · 2026 · Van der Borght E, Van der Schueren B, Vangoitsenhoven R, et al.
  PMID 42222073DOI 10.3389/fendo.2026.1815903
• Hypothalamic Regulation of the Gonadal Axis and Roles of Leptin and Insulin in It.
  Biochemistry. Biokhimiia · 2026 · Zorina II, Derkach KV, Shpakov AO, et al.
  PMID 42219385DOI 10.1134/S0006297926600353
• New regulators of parathyroid hormone secretion.
  Current opinion in nephrology and hypertension · 2026 · Naveh-Many T, Brook E, Hassan A, et al.
  PMID 42199077DOI 10.1097/MNH.0000000000001190
• Protein Restriction Increases Soluble Leptin Receptor via a Leptin-Dependent Mechanism Without Affecting Leptin-Induced Appetite Suppression in Mice.
  Nutrients · 2026 · Uchiyama M, Toyama T, Takei Y, et al.
  PMID 42196942DOI 10.3390/nu18101482
• Enhanced label-free SERS detection of uremic toxins in clinical spent dialysate.
  Analytica chimica acta · 2026 · Lee H, Liao JD, Guo YS, et al.
  PMID 42191305DOI 10.1016/j.aca.2026.345601
• The Leptin Renaissance: Orchestrating the Next Endocrine Paradigm.
  Journal of cellular biochemistry · 2026 · Junaid M, Zeming H, Zhu Y, et al.
  PMID 42159080DOI 10.1002/jcb.70091

The 10 most recently updated of 254 ClinicalTrials.gov registrations naming Leptin as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Biomarkers in Bone Marrow Supernatant for Predicting AML Chemosensitivity
  Recruiting · Observational · 405 enrolled · Fujian Medical University Union Hospital
  NCT07587944updated 2026-05-14
• Effect of Diet Supplementation With Amaranth Protein on Mexican Children With Overweight and Obesity
  Completed · Interventional · 56 enrolled · Instituto Potosino De Investigacion Cientifica Y Tecnologica AC
  NCT07583043updated 2026-05-13
• Compassionate Use of Metreleptin in Previously Treated People With Generalized Lipodystrophy
  Active not recruiting · Phase 3 · Interventional · 24 enrolled · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  NCT02262832updated 2026-05-12
• Compassionate Use of Metreleptin in Previously Treated People With Partial Lipodystrophy
  Active not recruiting · Phase 2 · Interventional · 29 enrolled · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  NCT02262806updated 2026-05-12
• The Effect of Adiponectin-Leptin Ratio on Weight Loss in Patients Undergoing Sleeve Gastrectomy Due to Morbid Obesity
  Completed · Observational · 78 enrolled · Sercan YUKSEL, MD
  NCT07564973updated 2026-05-07
• Lymphedema Surveillance Study
  Recruiting · Observational · 1,250 enrolled · Memorial Sloan Kettering Cancer Center
  NCT02743858updated 2026-05-07
• A Study of Tirzepatide (LY3298176) Plus Mibavademab Compared With Tirzepatide Alone in Adult Participants With Obesity
  Completed · Phase 2 · Interventional · 392 enrolled · Eli Lilly and Company
  NCT06373146updated 2026-05-06
• Study of the Hypothalamic Microglial Response as a Function of a Meal's Lipid Content in Humans. A Single-center Prospective Cohort Study in Healthy Male Subjects
  Not yet recruiting · Observational · 20 enrolled · Centre Hospitalier Universitaire Dijon
  NCT07557628updated 2026-04-29
• The Effects of Four Instant Maize Porridges on Satiety Measures
  Completed · Interventional · 50 enrolled · PepsiCo Global R&D
  NCT07204470updated 2026-04-21
• Effect of a Low-Calorie MCT-Rich Traditional Minangkabau Diet on Obese Individuals
  Not yet recruiting · Interventional · 40 enrolled · Andalas University
  NCT07423884updated 2026-04-13

Frequently asked questions

What is Leptin used for?

According to FDA labeling, Leptin carries indications including: Food cravings, great appetite, regurgitation of food, nausea, eating relieves discomfort, constant belching, bloating, sluggish, overweight.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.