pharmacopeia
GET
/api/v1/drug/loperamide
2D structure
4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
SMILES CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4
InChIKey RDOIQAHITMMDAJ-UHFFFAOYSA-N

Mechanism of action

Sourced from openFDA

Mechanism-of-action class: Opioid Agonists.

Opioid

Indications

Sourced from openFDA
  • Use controls symptoms of diarrhea, including Travelers’ Diarrhea

Dosage & administration

Sourced from openFDA

Directions • drink plenty of clear fluids to help prevent dehydration caused by diarrhea • find right dose on chart. If possible, use weight to dose; otherwise use age. • shake well before using • use only enclosed dosing cup specifically designed for use with this product. Do not use any other dosing device. • mL = milliliter adults and children 12 years and over 30 mL after the first loose stool; 15 mL after each subsequent loose stool; but no more than 60 mL in 24 hours children 9-11 years (60-95 lbs) 15 mL after the first loose stool; 7.5 mL after each subsequent loose stool; but no more than 45 mL in 24 hours children 6-8 years (48-59 lbs) 15 mL after the first loose stool; 7.5 mL after each subsequent loose stool; but no more than 30 mL in 24 hours children 2-5 years (34 to 47 lbs) ask a doctor children under 2 years (up to 33 lbs) do not use

Warnings & precautions

Sourced from openFDA

Allergy alert: Do not use if you have ever had a rash or other allergic reaction to loperamide HCl Heart alert: Taking more than directed can cause serious heart problems or death Do not use if you have bloody or black stool Ask a doctor before use if you have • fever • mucus in the stool • a history of liver disease • a history of abnormal heart rhythm Ask a doctor or pharmacist before use if you are taking a prescription drug. Loperamide may interact with certain prescription drugs. When using this product tiredness, drowsiness or dizziness may occur. Be careful when driving or operating machinery. Stop use and ask a doctor if • symptoms get worse • diarrhea lasts for more than 2 days • you get abdominal swelling or bulging. These may be signs of a serious condition. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222)

Approval history

Sourced from openFDA
  • Mar 1, 1988NDANDA019487Kenvue Brands
  • Sep 18, 1991ANDAANDA072741Mylan
  • Apr 30, 1992ANDAANDA073192Teva
  • Dec 10, 1992ANDAANDA074091Ohm Labs
  • Jan 6, 2000ANDAANDA075232L Perrigo Co
  • Nov 30, 2000NDANDA021140Kenvue Brands
  • Jun 10, 2003ANDAANDA076497Lnk
  • Aug 4, 2005NDANDA021855Bionpharma

FAERS reports

View JSON
Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
51,541 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
  1. 1Diarrhoea9,27218%
  2. 2Drug Ineffective5,33010%
  3. 3Nausea4,4628.7%
  4. 4Fatigue3,9907.7%
  5. 5Off Label Use3,5616.9%
  6. 6Vomiting2,9595.7%
  7. 7Constipation2,6445.1%
  8. 8Incorrect Dose Administered2,2014.3%
  9. 9Weight Decreased2,1554.2%
  10. 10Dyspnoea2,0854.0%
  11. 11Headache2,0494.0%
  12. 12Abdominal Pain1,8943.7%
  13. 13Asthenia1,8933.7%
  14. 14Decreased Appetite1,8323.6%
  15. 15Dizziness1,7993.5%

Literature

View JSON

Recent PubMed references pinned to Loperamide as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

Clinical trials

View JSON

The 10 most recently updated of 115 ClinicalTrials.gov registrations naming Loperamide as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

Frequently asked questions

How does Loperamide work?
Mechanism-of-action class: Opioid Agonists.
What is Loperamide used for?
According to FDA labeling, Loperamide carries indications including: Use controls symptoms of diarrhea, including Travelers’ Diarrhea. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
What class of drug is Loperamide?
Loperamide is classified as Antipropulsives, Opioid Agonist, Opioid Agonists, Decreased GI Motility, Stimulation Large Intestine Fluid/Electrolyte Absorption, Stimulation Small Intestine Fluid/Electrolyte Absorption.
What are the brand names for Loperamide?
Loperamide is marketed under brand names including Diamode, Imodium, Imodium Advanced, Imodium Multi-Symptom Relief.
Note. Data for loperamide is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.

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