Magnesium
/api/v1/drug/magnesiumMechanism of action
Sourced from openFDAMechanism-of-action classes: Acid-Base Activity; Electrolyte Activity; Enzyme Interactions.
Indications
Sourced from openFDA- Uses: • For relief of occasional constipation (irregularity).ICD-10: K59.00
Dosage & administration
Sourced from openFDADirections: • shake well before using • drink a full glass (8 ounces) of liquid with each dose • may be taken as a single daily dose or in divided doses adults and children 12 years of age and over 6.5 to 10 fl oz maximum 10 fl oz in 24 hours children 6 to under 12 years of age 3 to 7 fl oz maximum 7 fl oz in 24 hours children 2 to under 6 years of age 2 to 3 fl oz maximum 3 fl oz in 24 hours children under 2 years of age ask a doctor
Warnings & precautions
Sourced from openFDAAsk a doctor before use if you have • Kidney disease • a magnesium restricted diet • Abdominal pain, nausea, or vomiting • Noticed a sudden change in bowel habits that persists over a period of 2 weeks • Already used a laxative for a period longer than 1 week Ask a doctor or pharmacist before use if you are • Taking any other drug. • Take this product 2 or more hours before or after other drugs. Laxatives may affect how other drugs work. Stop use and ask a doctor if you have rectal bleeding or failure to have a bowel movement after use. These could be signs of a serious condition. If pregnant or breast-feeding , ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.
Approval history
Sourced from openFDA- Aug 13, 1975NDANDA017586Otsuka Icu Medcl
- Aug 13, 1975NDANDA017609Otsuka Icu Medcl
- Aug 13, 1975NDANDA017610Otsuka Icu Medcl
- Sep 27, 1978NDANDA017512Vantive Us Hlthcare
- Feb 2, 1979NDANDA017378Baxter Hlthcare
- Feb 2, 1979NDANDA017484Baxter Hlthcare
- Feb 19, 1982NDANDA018508Baxter Hlthcare
- Feb 26, 1982NDANDA018608Hospira
FAERS reports
- 1Nausea51,5386.3%
- 2Fatigue45,9825.7%
- 3Diarrhoea45,4665.6%
- 4Drug Ineffective43,7725.4%
- 5Chronic Kidney Disease42,7365.3%
- 6Dyspnoea37,5574.6%
- 7Pain36,2824.5%
- 8Headache36,0784.4%
- 9Vomiting34,6344.3%
- 10Off Label Use32,2094.0%
- 11Dizziness30,7683.8%
- 12Acute Kidney Injury30,5793.8%
- 13Malaise28,5643.5%
- 14Death28,3163.5%
- 15Asthenia26,3803.2%
Literature
Recent PubMed references pinned to Magnesium as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- The effect of yttrium addition on the ratcheting behavior of magnesium.PloS one · 2026 · Shou H, Song Y, Yang Y, et al.PMID 42247348DOI 10.1371/journal.pone.0348195
- Magnesium as a Bioenergetic Checkpoint Linking Mitochondrial Function, Metabolic Disease, and Aging.Aging cell · 2026 · Huang CW, Wen CY, Tsai AP, et al.PMID 42244260DOI 10.1111/acel.70578
- Mechanistic origin of high-cycle fatigue enhancement by grain refinement in AZ81 magnesium alloy for sports equipment.PloS one · 2026 · Li D, He LPMID 42241416DOI 10.1371/journal.pone.0350435
- Atomistic insight into Al-Mg friction stir welding process via molecular dynamics simulation.PloS one · 2026 · Nguyen VT, Hoang VH, Nguyen TT, et al.PMID 42241404DOI 10.1371/journal.pone.0350194
- Techno-Economic and Environmental Assessment of Magnesium-Impregnated Rice Husk Biochar for Nutrient Removal: A Scale-Up and Prospective Soil Application Approach.Water environment research : a research publication of the Water Environment Federation · 2026 · Lugo-Arias J, Villa-Parejo J, Escorcia G, et al.PMID 42240580DOI 10.1002/wer.70434
- Correlations between Serum Magnesium and PTH Levels and Vascular Calcification in Patients Undergoing Hemodialysis and Study of Associated Factors.Iranian journal of kidney diseases · 2025 · Wu X, Ding QPMID 42234877
- Magnesium in acute pediatric asthma in the emergency department (MAGICIAN)-A multicentre randomized controlled clinical trial protocol.PloS one · 2026 · Schuh S, O'Shea S, Freedman SB, et al.PMID 42234723DOI 10.1371/journal.pone.0349553
- Magnesium neuroprotection in retinal ganglion cells: A computational study of frequency-dependent therapeutic windows and intervention timing.PloS one · 2026 · Borjkhani M, Borjkhani H, Sharif MA, et al.PMID 42224261DOI 10.1371/journal.pone.0348068
Clinical trials
The 10 most recently updated of 2,049 ClinicalTrials.gov registrations naming Magnesium as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.
- Effect of MEMOPTIC on Visual Field of Patients Followed for a Chronic Open-angle GlaucomaTerminated · Interventional · 15 enrolled · Centre Hospitalier Universitaire, AmiensNCT04499157updated 2026-06-12
- Dietary Insights and Nutritional Education in Adults on GLP-1 TherapyRecruiting · Interventional · 50 enrolled · University of South CarolinaNCT07518407updated 2026-06-12
- Transcranial Doppler in Preeclampsia and Its Complications.Completed · Observational · 100 enrolled · University Tunis El ManarNCT07646561updated 2026-06-12
- Treating Exacerbations of Asthma With Oral Montelukast in ChildrenCompleted · Phase 2 · Interventional · 90 enrolled · Vanderbilt University Medical CenterNCT05819541updated 2026-06-12
- UCLA Magnesium Formulation Athlete StudyNot yet recruiting · Interventional · 150 enrolled · University of California, Los AngelesNCT07640685updated 2026-06-11
- An Initial Investigation Into the Effects of β-Alanine on Performance and Physiological Responses During Simulated Wrestling MatchesActive not recruiting · Interventional · 16 enrolled · China Medical University HospitalNCT07641907updated 2026-06-11
- A Novel Cold and Flu Herbal Blend for Reducing the Duration and Severity of the Common ColdNot yet recruiting · Phase 2 · Interventional · 300 enrolled · RDC Clinical Pty LtdNCT07642648updated 2026-06-11
- The Basel BOMP-AID Randomized TrialRecruiting · Phase 4 · Interventional · 190 enrolled · University Hospital, Basel, SwitzerlandNCT03438526updated 2026-06-11
- Effect of Magnesium-, Vitamin C- and Grape Seed Extract-Enriched Date Bars on Perceived Stress and Salivary Cortisol Levels in Young WomenActive not recruiting · Interventional · 30 enrolled · K.G. Razumovsky Moscow State University of Technologies and ManagementNCT07585422updated 2026-06-10
- Pacritinib With Aza for Upfront Myelodysplastic SyndromeNot yet recruiting · Phase 1 · Phase 2 · Interventional · 25 enrolled · Thomas Jefferson UniversityNCT07387354updated 2026-06-10
Frequently asked questions
- How does Magnesium work?
- Mechanism-of-action classes: Acid-Base Activity; Electrolyte Activity; Enzyme Interactions.
- What is Magnesium used for?
- According to FDA labeling, Magnesium carries indications including: Uses: • For relief of occasional constipation (irregularity).. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
- What class of drug is Magnesium?
- Magnesium is classified as Acid-Base Activity, Electrolyte Activity, Enzyme Interactions, Cellular Activity Alteration.
magnesium is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.