Magnesium Chloride

Mechanism-of-action classes: Acid-Base Activity; Electrolyte Activity; Enzyme Interactions.

• As an electrolyte replenisher in magnesium deficiencies.

• Magnesium Chloride Injection should not be administered if there is renal impairment, marked myocardial disease or to comatose patients.contraindicated

For intravenous infusion: 4 grams in 250 mL of 5% Dextrose Injection, at a rate not exceeding 3 mL per minute. Serum magnesium levels should serve as a guide to continued dosage.

Do not use if a precipitate is present.

Flushing, sweating, sharply lowered blood pressure, hypothermia, stupor and ultimately respiratory depression.

Pregnancy Animal reproduction studies have not been conducted with magnesium chloride. It is also not known whether magnesium chloride can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Magnesium Chloride should be given to a pregnant woman only if clearly needed.

• Aug 13, 1975NDANDA017586Otsuka Icu Medcl
• Aug 13, 1975NDANDA017609Otsuka Icu Medcl
• Sep 27, 1978NDANDA017512Vantive Us Hlthcare
• Feb 2, 1979NDANDA017378Baxter Hlthcare
• Feb 2, 1979NDANDA017484Baxter Hlthcare
• Feb 26, 1982NDANDA018608Hospira
• Jun 8, 1984NDANDA019024B Braun
• Jul 20, 1984NDANDA018895Hospira

1. 1Death7,64615%
2. 2Peritonitis3,8617.7%
3. 3Peritonitis Bacterial2,5245.1%
4. 4Peritoneal Dialysis Complication1,7483.5%
5. 5Hypotension1,6503.3%
6. 6Myocardial Infarction1,5163.0%
7. 7Pneumonia1,4152.8%
8. 8Infection1,4032.8%
9. 9Dyspnoea1,2862.6%
10. 10Sepsis1,2382.5%
11. 11Fluid Overload1,1992.4%
12. 12Abdominal Pain1,1922.4%
13. 13Abdominal Distension1,1652.3%
14. 14Malaise1,1042.2%
15. 15Vomiting1,0912.2%

Recent PubMed references pinned to Magnesium Chloride as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Evaluation of the effects of Plasma-Lyte 148 or 0.9% saline on acid-base balance in patients undergoing neurosurgery: a randomized clinical trial.
  Einstein (Sao Paulo, Brazil) · 2026 · Thom MM, Barros GAM, Fonseca LGF, et al.
  PMID 42018822DOI 10.31744/einstein_journal/2026AO1574
• Chaotropic ions reshape the cell wall of the obligate halophile aspergillus atacamensis: Insights from solid-state NMR.
  Carbohydrate polymers · 2026 · Gautam I, Muñoz GV, Karai A, et al.
  PMID 41943379DOI 10.1016/j.carbpol.2026.125157
• Innovative MgCl(2) -mediated two-step precipitation-dissolution strategy for efficient purification of Porcine Circovirus Type 2 capsid protein and self-assembly of virus-like particles.
  International journal of biological macromolecules · 2026 · Chen Q, Du Y, Feng L, et al.
  PMID 41825666DOI 10.1016/j.ijbiomac.2026.151389
• Thermodynamic Inhibition of Carbon Dioxide Hydrate with Magnesium Chloride and Methanol: Comparative Phase Equilibrium and PXRD Study.
  International journal of molecular sciences · 2026 · Semenov A, Mendgaziev R, Stoporev A, et al.
  PMID 41751929DOI 10.3390/ijms27041792
• Cellular responses of Aspergillus sydowii to growth at extreme chaotropic concentrations of MgCl(2).
  Microbiological research · 2026 · González-Abradelo D, de León LR, Gesto-Borroto R, et al.
  PMID 41260032DOI 10.1016/j.micres.2025.128390
• Hedonic threshold methodology varying three stimuli using a central composite rotatable design: Application to NaCl replacement with KCl and MgCl₂ in sliced bread.
  Food research international (Ottawa, Ont.) · 2025 · Gualande MRB, Rodrigues MM, Silva CMOD, et al.
  PMID 41174452DOI 10.1016/j.foodres.2025.117379
• Magnesium chloride supplementation reduces risk of gestational diabetes by improving glucose levels and controlling body weight gain in diet-induced obese, hypomagnesaemic rats: a pilot study.
  Magnesium research · 2024 · Gamboa-Gómez CI, Alvarado-Aguilar P, Martínez-Aguilar G, et al.
  PMID 41003543DOI 10.1684/mrh.2025.0545
• Modification of reduced-sodium carp myofibrillar protein by a combined strategy with ultrasound and MgCl(2) treatment: physicochemical, structural and functional properties.
  Ultrasonics sonochemistry · 2025 · Zhao S, Wang Z, Zhai L, et al.
  PMID 40957280DOI 10.1016/j.ultsonch.2025.107563

The 10 most recently updated of 210 ClinicalTrials.gov registrations naming Magnesium Chloride as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• MAGNEsium With meToprolol for Rate Control In Atrial Fibrillation
  Not yet recruiting · Phase 3 · Interventional · 196 enrolled · Wake Forest University Health Sciences
  NCT07632157updated 2026-06-08
• Pharmacokinetic (PK) Evaluation of Nalmefene Formulations
  Completed · Phase 1 · Interventional · 13 enrolled · Knoa Pharma LLC
  NCT07543276updated 2026-06-05
• Comparison of 1 Liter PEG With Ascorbate and Sodium Picosulfate / Magnesium Citrate for High Quality Colon Cleansing
  Completed · Phase 4 · Interventional · 1,180 enrolled · Parc de Salut Mar
  NCT04598880updated 2026-05-14
• PROMOTE: The Effect of a Six Week Prebiotic Supplementation on Wellbeing of Young Adults.
  Withdrawn · Interventional · 0 enrolled · University of Southampton
  NCT06566157updated 2026-05-13
• Probiotic Treatment for Depression and Associated Mood Disorders in Parkinson's Disease
  Recruiting · Phase 2 · Interventional · 60 enrolled · University of British Columbia
  NCT05568498updated 2026-05-08
• The Effect of Different Types of Mouthwash on Extraction Sockets' Healing
  Recruiting · Phase 4 · Interventional · 100 enrolled · University of Jordan
  NCT06587880updated 2026-05-07
• Theravex® for Burning Mouth Syndrome
  Completed · Interventional · 116 enrolled · Biointelligent Technology Systems SL
  NCT07564843updated 2026-05-04
• POTENT - Tepotinib in Combination With Pembrolizumab in NSCLC
  Active not recruiting · Phase 1 · Interventional · 19 enrolled · Institute of Cancer Research, United Kingdom
  NCT05782361updated 2026-04-24
• Phosphate-Containing Replacement Fluid for Patients Undergoing CRRT
  Not yet recruiting · Phase 3 · Interventional · 220 enrolled · Sun Yat-sen University
  NCT07550894updated 2026-04-24
• MAG-PAIN - MAGnesium for Postoperative Analgesia In the Newly Delivered
  Not yet recruiting · Phase 2 · Interventional · 150 enrolled · Region Halland
  NCT07528612updated 2026-04-17

Frequently asked questions

How does Magnesium Chloride work?

Mechanism-of-action classes: Acid-Base Activity; Electrolyte Activity; Enzyme Interactions.

What is Magnesium Chloride used for?

According to FDA labeling, Magnesium Chloride carries indications including: As an electrolyte replenisher in magnesium deficiencies.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Magnesium Chloride?

Magnesium Chloride is classified as Electrolyte solutions, Magnesium, Acid-Base Activity, Electrolyte Activity, Enzyme Interactions, Cellular Activity Alteration.

What are the brand names for Magnesium Chloride?

Magnesium Chloride is marketed under brand names including Aminosyn 8.5 % with Electrolytes, Sulfite-Free, Aminosyn II 8.5 % with Electrolytes, Sulfite-Free, BSS Ophthalmic Solution, Chloromag, Clinimix E 2.75/5, Clinimix E 4.25/10, Clinimix E 4.25/5, Clinimix E 5/15.

What are the contraindications for Magnesium Chloride?

Magnesium Chloride labeling lists contraindications including: Magnesium Chloride Injection should not be administered if there is renal impairment, marked myocardial disease or to comatose patients.. Always consult the full prescribing information and a clinician.