Magnesium Hydroxide

Mechanism-of-action classes: Acid-Base Activity; Electrolyte Activity; Enzyme Interactions; Osmotic Activity.

• Uses relieves occasional constipation (irregularity) generally produces bowel movement in 1/2 to 6 hoursICD-10: K59.00

Directions shake well before use do not exceed the maximum recommended daily dose in a 24 hour period dose may be taken once a day preferably at bedtime, in divided doses, or as directed by a doctor drink a full glass (8 oz) of liquid with each dose for accurate dosing, only use the dosing cup provided mL = milliliter age dose adults and children 12 years and over 30 mL to 60 mL children 6 to 11 years 15 mL to 30 mL children under 6 years ask a doctor

Ask a doctor before use if you have kidney disease a magnesium-restricted diet stomach pain, nausea, or vomiting a sudden change in bowel habits that lasts over 14 days ​ Ask a doctor or pharmacist before use if you are presently taking a prescription drug. This product may interact with certain prescription drugs. Stop use and ask a doctor if you have rectal bleeding or no bowel movement after using this product. These could be signs of a serious condition. you need to use a laxative for more than 1 week If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center (1-800-222-1222) right away.

• Oct 16, 2000NDANDA020958Kenvue Brands
• Feb 6, 2008ANDAANDA077355Perrigo R And D

1. 1Chronic Kidney Disease2,97516%
2. 2Acute Kidney Injury1,8389.9%
3. 3Constipation1,7029.2%
4. 4Renal Failure1,6238.8%
5. 5Drug Ineffective1,3367.2%
6. 6Pain1,3237.1%
7. 7Fall1,2586.8%
8. 8Nausea1,2516.8%
9. 9Diarrhoea1,0835.9%
10. 10Fatigue9385.1%
11. 11End Stage Renal Disease9044.9%
12. 12Hypotension8994.9%
13. 13Off Label Use8934.8%
14. 14Death8144.4%
15. 15Vomiting7994.3%

Recent PubMed references pinned to Magnesium Hydroxide as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• A novel composite of Mg-Al layered double hydroxide/aeolian sand for enhanced removal of fluoride from water.
  Environmental geochemistry and health · 2026 · Li Q, Jin Z, Zhou J, et al.
  PMID 42151459DOI 10.1007/s10653-026-03237-1
• Remediation of cadmium-contaminated soils by mercaptosuccinic acid-intercalated hydrotalcite: Effects on soil quality and cadmium accumulation in rice.
  Journal of environmental management · 2026 · He L, Ding C, Nie M, et al.
  PMID 41905143DOI 10.1016/j.jenvman.2026.129506
• A hydrogen-bonded network of wood sawdust/magnesium hydroxide constructed with sodium carboxymethyl cellulose for efficient heavy metal removal.
  International journal of biological macromolecules · 2026 · Liu J, Sang M, Yang T, et al.
  PMID 41855782DOI 10.1016/j.ijbiomac.2026.151543
• MgFe-LDH nanocomposites incorporated into gelatin methacryloyl /hyaluronic acid methacrylated hydrogels for controlled drug release: Synergistic regulation of angiogenesis-osteogenesis for bone regeneration.
  International journal of biological macromolecules · 2026 · Lian L, He C, Dong Y, et al.
  PMID 41548783DOI 10.1016/j.ijbiomac.2026.150328
• Fabrication of chitosan-magnesium hydroxide hydrogels for efficient removal of copper ions.
  International journal of biological macromolecules · 2026 · Zhou ZX, Zheng WX, Tan YZ, et al.
  PMID 41485650DOI 10.1016/j.ijbiomac.2026.150081
• Synthesis of graphene oxide/magnesium hydroxide/carboxymethyl cellulose biopolymeric thin films for enhanced adsorption-precipitation of Cr(III).
  International journal of biological macromolecules · 2025 · Wafiyah A, Taleb MA, Kumar R, et al.
  PMID 41138867DOI 10.1016/j.ijbiomac.2025.148472
• Scalable and sustainable process of spike spherical Mg(OH)2 adsorbent from magnesite by ammonia-cycle method for dye removal.
  PloS one · 2025 · Duan X, Wang C, Zhang Y, et al.
  PMID 40956825DOI 10.1371/journal.pone.0332393
• Comparing the Bioavailability of Two Seawater-Derived Magnesium Preparations.
  Journal of medicinal food · 2025 · McFarlin BK, Paschall AL, Kelly ME, et al.
  PMID 40955524DOI 10.1177/1096620X251380191

The 10 most recently updated of 73 ClinicalTrials.gov registrations naming Magnesium Hydroxide as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Famotidine and Antacids for Treatment of Dyspepsia
  Recruiting · Phase 4 · Interventional · 80 enrolled · Stony Brook University
  NCT06241183updated 2026-06-02
• 12-week Magnesium Supplementation on Peri-menopause Symptoms, Cognition, Sleep, and Psychological Well-being
  Recruiting · Interventional · 58 enrolled · Northumbria University
  NCT07235878updated 2026-05-29
• Alginate vs Sucralfate for GERD Symptomatic Relief
  Completed · Phase 2 · Phase 3 · Interventional · 140 enrolled · CMH Lahore Medical College and Institute of Dentistry
  NCT07310927updated 2026-04-21
• RELISTOR's Effects on Opioid-Induced Constipation
  Withdrawn · Observational · 0 enrolled · Methodist Health System
  NCT04930237updated 2026-03-23
• Study to Evaluate the Efficacy, Safety, and Tolerability of Long-acting Intramuscular Cabotegravir and Rilpivirine for Maintenance of Virologic Suppression Following Switch From an Integrase Inhibitor in HIV-1 Infected Therapy Naive Participants
  Active not recruiting · Phase 3 · Interventional · 631 enrolled · ViiV Healthcare
  NCT02938520updated 2026-03-19
• Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis
  Completed · Phase 3 · Interventional · 9,041 enrolled · Children's Hospital of Philadelphia
  NCT04102371updated 2026-03-05
• Optimization of Postoperative Bowel Habits
  Recruiting · Interventional · 88 enrolled · Wake Forest University Health Sciences
  NCT06335797updated 2026-02-27
• A Study Comparing Different Treatment Approaches for the Initiation of Puberty in Girls With Turner Syndrome Using a TRIFECTA-DARED Approach for Rare Diseases
  Not yet recruiting · Phase 2 · Interventional · 24 enrolled · Universiti Kebangsaan Malaysia Medical Centre
  NCT07041814updated 2026-02-02
• Study Evaluating the Efficacy, Safety, and Tolerability of Switching to Long-acting Cabotegravir Plus Long-acting Rilpivirine From Current Antiretroviral Regimen in Virologically Suppressed HIV-1-infected Adults
  Active not recruiting · Phase 3 · Interventional · 618 enrolled · ViiV Healthcare
  NCT02951052updated 2025-12-31
• Effects of Photobiomodulation (PBM) on Pain After Presentation of Aphthous Ulcers in Pediatric Dental Patients
  Recruiting · Phase 4 · Interventional · 30 enrolled · The University of Texas Health Science Center, Houston
  NCT06819033updated 2025-03-25

Frequently asked questions

How does Magnesium Hydroxide work?

Mechanism-of-action classes: Acid-Base Activity; Electrolyte Activity; Enzyme Interactions; Osmotic Activity.

What is Magnesium Hydroxide used for?

According to FDA labeling, Magnesium Hydroxide carries indications including: Uses relieves occasional constipation (irregularity) generally produces bowel movement in 1/2 to 6 hours. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Magnesium Hydroxide?

Magnesium Hydroxide is classified as Magnesium compounds, Other urologicals, Acid-Base Activity, Electrolyte Activity, Enzyme Interactions, Osmotic Activity, Cellular Activity Alteration, Gastric Acid Alteration, Small Intestine Fluid/Electrolyte Absorption Alteration.

What are the brand names for Magnesium Hydroxide?

Magnesium Hydroxide is marketed under brand names including Almacone, Comfort Gel, Duo Fusion, Gelusil, Inon Ace Solution, Inon Ace Tablet, Maalox Max, Maalox Plus.