Malic Acid
US-FDASourced from openFDA
GET
/api/v1/drug/malic-acidIndications
Sourced from openFDA- USES TAKE 15 MINUTES BEFORE MEALS
Dosage & administration
Sourced from openFDADIRECTIONS Take 15 minutes before meals Adults : 20 drops in a little water, 2 times per day
Warnings & precautions
Sourced from openFDAStop use and ask doctor if symptoms persist more than 5 days. If pregnant or breast-feeding ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. Contains ethyl alcohol 30%
FAERS reports
Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
15 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
- 1Dizziness320%
- 2Fall320%
- 3Fatigue320%
- 4Covid-19213%
- 5Headache213%
- 6Hypotension213%
- 7Malaise213%
- 8Neuropathy Peripheral213%
- 9Pain213%
- 10Vomiting213%
- 11Adverse Drug Reaction16.7%
- 12Anaemia16.7%
- 13Arthralgia16.7%
- 14Arthropod Bite16.7%
- 15Asthenia16.7%
Literature
Recent PubMed references pinned to Malic Acid as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- Organic acids counteract the determinate root development induced by phosphate deprivation in Arabidopsis thaliana.Plant signaling & behavior · 2026 · Corona-Sánchez I, López-Bucio J, Villalobos-Escobedo JM, et al.PMID 42026737DOI 10.1080/15592324.2026.2662710
- Copper extraction and phytotoxicity of organic acid leached mine tailings in Brassica napus.Environmental geochemistry and health · 2026 · De Oliveira VH, Duddigan S, Symons J, et al.PMID 41981322DOI 10.1007/s10653-026-03188-7
- A new isolated fungus Talaromyces sp. MC-F2 efficiently solubilizes phosphate through media-dependent metabolic regulation.Scientific reports · 2026 · Xia M, Bao P, He S, et al.PMID 41851404DOI 10.1038/s41598-026-44554-w
- Strain-Specific Phosphate Mobilization in Enterobacter: Organic Acid Production and Genomic Architecture of Solubilization Mechanisms.International journal of molecular sciences · 2025 · Sokolova EA, Khlistun IV, Mishukova OV, et al.PMID 41516198DOI 10.3390/ijms27010322
- Transcriptome analysis of Pantoea rara mutants reveals the underlying complexity of bacterial phosphate solubilization.Microbiology spectrum · 2026 · Hone H, Li T, Wood JL, et al.PMID 41395942DOI 10.1128/spectrum.03363-25
- ALUMINUM-ACTIVATED MALATE TRANSPORTER 1 (ALMT1) partially acidifies the rhizosphere in Pi deficiency-induced inhibition of primary root growth.Plant signaling & behavior · 2025 · Wang Z, Xia M, Ma R, et al.PMID 41312599DOI 10.1080/15592324.2025.2590763
- Exogenous application of hydrogen sulfide combined with blue light improves the quality of pepper fruit minimizing oxidative stress during postharvest storage.Plant physiology and biochemistry : PPB · 2025 · Das A, Pal S, Adak MK, et al.PMID 41242221DOI 10.1016/j.plaphy.2025.110766
- Organic acid accumulation pattern and its key genes in Chinese cherry fruits.BMC genomics · 2025 · Wang Y, Zhou J, Liu X, et al.PMID 40855411DOI 10.1186/s12864-025-11969-0
Clinical trials
The 10 most recently updated of 327 ClinicalTrials.gov registrations naming Malic Acid as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.
- Pre-Surgical Sutent in Renal Cell Carcinoma (RCC)Active not recruiting · Phase 2 · Interventional · 50 enrolled · M.D. Anderson Cancer CenterNCT00715442updated 2026-06-12
- A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed OsteosarcomaRecruiting · Phase 2 · Phase 3 · Interventional · 1,122 enrolled · National Cancer Institute (NCI)NCT05691478updated 2026-06-12
- Testing Nivolumab and Ipilimumab Immunotherapy With or Without the Targeted Drug Cabozantinib in Recurrent, Metastatic, or Incurable Nasopharyngeal CancerRecruiting · Phase 2 · Interventional · 50 enrolled · National Cancer Institute (NCI)NCT05904080updated 2026-06-12
- Cabozantinib S-malate in Treating Patients With Relapsed Osteosarcoma or Ewing SarcomaActive not recruiting · Phase 2 · Interventional · 90 enrolled · National Cancer Institute (NCI)NCT02243605updated 2026-06-12
- Testing the Addition of the Anti-cancer Drug, Cabozantinib, to the Usual Immunotherapy Treatment, Avelumab, in Patients With Metastatic Urothelial Cancer, MAIN-CAV StudyActive not recruiting · Phase 3 · Interventional · 654 enrolled · National Cancer Institute (NCI)NCT05092958updated 2026-06-12
- Sunitinib Malate With Hormonal Ablation for Patients Who Will Have ProstatectomyActive not recruiting · Phase 2 · Interventional · 64 enrolled · M.D. Anderson Cancer CenterNCT00329043updated 2026-06-12
- Using Nivolumab Alone or With Cabozantinib to Prevent Mucosal Melanoma Return After SurgeryActive not recruiting · Phase 2 · Interventional · 101 enrolled · National Cancer Institute (NCI)NCT05111574updated 2026-06-11
- Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare TumorsActive not recruiting · Phase 2 · Interventional · 109 enrolled · National Cancer Institute (NCI)NCT02867592updated 2026-06-11
- Losartan + Sunitinib in Treatment of OsteosarcomaRecruiting · Phase 1 · Interventional · 41 enrolled · University of Colorado, DenverNCT03900793updated 2026-06-11
- Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary TumorsRecruiting · Phase 2 · Interventional · 314 enrolled · National Cancer Institute (NCI)NCT03866382updated 2026-06-11
Frequently asked questions
- What is Malic Acid used for?
- According to FDA labeling, Malic Acid carries indications including: USES TAKE 15 MINUTES BEFORE MEALS. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
- What are the brand names for Malic Acid?
- Malic Acid is marketed under brand names including Salivasure.
Note. Data for
malic-acid is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.