Manganese Gluconate

Mechanism-of-action classes: Enzyme Interactions; Physiochemical Activity.

• For temporary relief of digestion, dyspepsia, constipation, back pain extending to the legs, headaches extending from ear to ear, burning in stomach, and heartburn from sweets.ICD-10: K59.00, R51.9

DIRECTIONS: 10 drops orally, 3 times a day. Consult a physician for use in children under 12 years of age.

If pregnant or breast-feeding, ask a health care professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. Do not use if tamper evident seal is broken or missing. Store in cool, dry place.

1. 1Abdominal Pain133%
2. 2Cardiac Disorder133%
3. 3Diaphragmatic Disorder133%
4. 4Dysphagia133%
5. 5Gastric Disorder133%
6. 6Influenza Like Illness133%
7. 7Myasthenia Gravis133%
8. 8Nausea133%
9. 9Paralysis133%
10. 10Syncope133%
11. 11Transfusion133%
12. 12Vomiting133%

Recent PubMed references pinned to Manganese Gluconate as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• A catalase-like nanozyme of high activity and stability in acidic solutions for enzyme immobilization and chemoenzymatic cascade conversion of glucose to gluconic acid.
  Food chemistry · 2025 · Yang Z, Dong X, Wang Z, et al.
  PMID 40184740DOI 10.1016/j.foodchem.2025.144140
• Novel Use of Manganese Gluconate as a Marker for Visualization of Tablet Dissolution in the Fed Human Stomach Using Magnetic Resonance Imaging.
  Molecular pharmaceutics · 2025 · Akbar T, Gershkovich P, Stamatopoulos K, et al.
  PMID 39637400DOI 10.1021/acs.molpharmaceut.4c00854
• Is there a fast track ("Darmstrasse") for fluids in the small intestine? Evidence from magnetic resonance imaging.
  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2024 · Großmann L, Springub K, Krüger L, et al.
  PMID 38582180DOI 10.1016/j.ejpb.2024.114277
• Implications of the Mn:ligand ratio for Mn uptake by Glycine max L. plants fertilized with heptagluconate and gluconate complexes.
  Journal of the science of food and agriculture · 2021 · Islas-Valdez S, López-Rayo S, Lucena JJ, et al.
  PMID 33491224DOI 10.1002/jsfa.11110
• A single membrane-bound enzyme catalyzes the conversion of 2,5-diketo-d-gluconate to 4-keto-d-arabonate in d-glucose oxidative fermentation by Gluconobacter oxydans NBRC 3292.
  Bioscience, biotechnology, and biochemistry · 2016 · Tazoe M, Oishi H, Kobayashi S, et al.
  PMID 27010909DOI 10.1080/09168451.2016.1164584
• Protective effect of CV247 against cisplatin nephrotoxicity in rats.
  Human & experimental toxicology · 2014 · Máthé C, Szénási G, Sebestény A, et al.
  PMID 23653282DOI 10.1177/0960327113480972
• Mn bioavailability by polarized Caco-2 cells: comparison between Mn gluconate and Mn oxyprolinate.
  Nutrition journal · 2011 · Foglieni C, Cavarelli M, Piscopiello M, et al.
  PMID 21781350DOI 10.1186/1475-2891-10-77
• The influence of chemical activation on tooth bleaching using 10% carbamide peroxide.
  Operative dentistry · 2011 · Batista GR, Barcellos DC, Torres CR, et al.
  PMID 21777098DOI 10.2341/09-280-L

The 10 most recently updated of 615 ClinicalTrials.gov registrations naming Manganese Gluconate as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Staph Intervention for Effective Local Defense
  Completed · Phase 4 · Interventional · 78 enrolled · Johns Hopkins Bloomberg School of Public Health
  NCT06210594updated 2026-06-12
• Assessing the Efficacy of Photodynamic Therapy for Preventing Surgical Site Infections
  Recruiting · Interventional · 80 enrolled · Guy's and St Thomas' NHS Foundation Trust
  NCT06731881updated 2026-06-11
• Natural Enzyme Mouthwash After Third Molar Surgery
  Completed · Interventional · 58 enrolled · MBD MARKETING SDN. BHD.
  NCT07627945updated 2026-06-09
• Wound Irrigation With Saline Versus Hypodilute-chlorhexidine After Cesarean Section (WISHES Study)
  Recruiting · Interventional · 400 enrolled · Loma Linda University
  NCT06339203updated 2026-06-08
• Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib
  Active not recruiting · Phase 2 · Interventional · 305 enrolled · Janssen Research & Development, LLC
  NCT06120140updated 2026-06-05
• Disulfiram With Copper Gluconate and Liposomal Doxorubicin in Treatment-Refractory Sarcomas
  Recruiting · Phase 1 · Interventional · 24 enrolled · Case Comprehensive Cancer Center
  NCT05210374updated 2026-06-05
• CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial
  Recruiting · Phase 2 · Interventional · 1,050 enrolled · Jason Sperry
  NCT05958342updated 2026-06-03
• Effect of a Bioactive Mineral-Ionic Mouthrinse on Periodontal Soft Tissue Healing
  Completed · Interventional · 94 enrolled · Biointelligent Technology Systems SL
  NCT07611123updated 2026-05-29
• Cleaning Methods for Clear Aligners
  Completed · Interventional · 60 enrolled · Riyadh Elm University
  NCT07610603updated 2026-05-29
• Balanced Crystalloid vs Normal Saline in Pediatric Acute Gastroenteritis
  Recruiting · Observational · 180 enrolled · Aydin Adnan Menderes University
  NCT07610382updated 2026-05-28

Frequently asked questions

How does Manganese Gluconate work?

Mechanism-of-action classes: Enzyme Interactions; Physiochemical Activity.

What is Manganese Gluconate used for?

According to FDA labeling, Manganese Gluconate carries indications including: For temporary relief of digestion, dyspepsia, constipation, back pain extending to the legs, headaches extending from ear to ear, burning in stomach, and heartburn from sweets.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Manganese Gluconate?

Manganese Gluconate is classified as Enzyme Interactions, Physiochemical Activity, Cellular Activity Alteration, Increased Cholesterol Synthesis, Increased Gluconeogenesis.