pharmacopeia
GET
/api/v1/drug/meclizine
2D structure
1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine
SMILES CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl
InChIKey OCJYIGYOJCODJL-UHFFFAOYSA-N

Mechanism of action

Sourced from openFDA

Mechanism-of-action classes: Cholinergic Muscarinic Antagonists; Histamine H1 Receptor Antagonists.

Cholinergic MuscarinicHistamine H1 Receptor

Indications

Sourced from openFDA
  • Uses prevents and treats nausea, vomiting or dizziness associated with motion sicknessICD-10: R11.2

Dosage & administration

Sourced from openFDA

Directions dosage should be taken one hour before travel starts chew or crush tablets completely before swallowing; do not swallow tablets whole adults and children 12 years and over: take 1 to 2 chewable tablets once daily or as directed by a doctor

Warnings & precautions

Sourced from openFDA

Do not use in children under 12 years of age unless directed by a doctor. Ask a doctor before use if you have difficulty in urination due to enlargement of the prostate gland glaucoma a breathing problem such as emphysema or chronic bronchitis Ask a doctor or pharmacist before use if you are taking sedatives or tranquilizers. When using this product avoid alcoholic beverages alcohol, sedatives, and tranquilizers may increase drowsiness drowsiness may occur use caution when driving a motor vehicle or operating machinery If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

Approval history

Sourced from openFDA
  • Feb 14, 1957NDANDA010721Casper Pharma Llc
  • Jun 4, 2010ANDAANDA040659Jubilant Cadista
  • Feb 23, 2011ANDAANDA201451Amneal Pharms
  • Apr 13, 2012ANDAANDA200294Epic Pharma Llc
  • Sep 17, 2012ANDAANDA202640Aurobindo Pharma Usa
  • Jun 23, 2020ANDAANDA213957Zydus Lifesciences
  • Aug 11, 2022ANDAANDA203003Chartwell Rx

FAERS reports

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Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
19,124 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
  1. 1Dizziness1,91410%
  2. 2Nausea1,6978.9%
  3. 3Fatigue1,6108.4%
  4. 4Headache1,2426.5%
  5. 5Diarrhoea1,2066.3%
  6. 6Fall1,1786.2%
  7. 7Pain1,1586.1%
  8. 8Dyspnoea9875.2%
  9. 9Asthenia9595.0%
  10. 10Drug Ineffective9585.0%
  11. 11Chronic Kidney Disease9044.7%
  12. 12Vomiting8874.6%
  13. 13Vertigo7203.8%
  14. 14Anxiety7193.8%
  15. 15Off Label Use7073.7%

Literature

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Recent PubMed references pinned to Meclizine as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

Clinical trials

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The 10 most recently updated of 10 ClinicalTrials.gov registrations naming Meclizine as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

Pharmacogenomics

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CPIC-curated drug–gene pairs for Meclizine. Levels describe the strength of curated evidence and guideline status — never a recommendation to test or to adjust therapy.

  • CYP2D6CPIC B/C (provisional)FDA label: Actionable PGx

Structural analogs

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Ranked by 2D fingerprint (Tanimoto) similarity over PubChem structures. Structural proximity only — not a claim of therapeutic equivalence.

Frequently asked questions

How does Meclizine work?
Mechanism-of-action classes: Cholinergic Muscarinic Antagonists; Histamine H1 Receptor Antagonists.
What is Meclizine used for?
According to FDA labeling, Meclizine carries indications including: Uses prevents and treats nausea, vomiting or dizziness associated with motion sickness. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
What class of drug is Meclizine?
Meclizine is classified as Piperazine derivatives, Antiemetic, Cholinergic Muscarinic Antagonists, Histamine H1 Receptor Antagonists, Decreased Acetylcholine Activity, Decreased Histamine Activity, Emesis Suppression.
What are the brand names for Meclizine?
Meclizine is marketed under brand names including Antivert, Bonine, Dramamine Less Drowsy, Dramamine Nausea Relief, Pepto Nausea, Verticalm, Wal-Dram 2, Zentrip.
Note. Data for meclizine is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.

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