Methyl Salicylate

Mechanism-of-action classes: Cyclooxygenase Inhibitors; Prostaglandin Receptor Antagonists.

• Uses For the temporary relief of minor aches and pains of muscles and joints associated with: simple backache arthrits strains sprains

Directions use only as directed adults and children 12 years of age and older: apply to affected area no more than 3 to 4 times daily children under 12 years of age: ask a doctor

For external use only. Do not use otherwise than as directed.

• Feb 20, 2008NDANDA022029Hisamitsu Pharm Co
• May 27, 2014ANDAANDA202027Apotex

1. 1Drug Ineffective35717%
2. 2Pain1416.7%
3. 3Application Site Pain1245.9%
4. 4No Adverse Event1235.9%
5. 5Nausea1165.6%
6. 6Diarrhoea1115.3%
7. 7Pruritus964.6%
8. 8Dyspnoea914.4%
9. 9Fatigue914.4%
10. 10Application Site Burn904.3%
11. 11Headache894.3%
12. 12Arthralgia884.2%
13. 13Off Label Use813.9%
14. 14Back Pain763.6%
15. 15Intentional Product Misuse713.4%

Recent PubMed references pinned to Methyl Salicylate as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Functional characterization of CaspOR20 involved in repellency of 1-penten-3-ol, sulcatone, and methyl salicylate against the rape stem weevil Ceutorhynchus asper.
  Insect biochemistry and molecular biology · 2026 · Rao F, Yang J, Peng D, et al.
  PMID 42203155DOI 10.1016/j.ibmb.2026.104595
• Aspirin in Audiology: A Dual-Edged Sword in Hearing Loss and Its Nanotechnology-Driven Future.
  Drug design, development and therapy · 2026 · Yang Y, Tian C, An X, et al.
  PMID 42199810DOI 10.2147/DDDT.S605798
• Drought stress induces salicylic acid accumulation, altering monoterpene profile and suppressing resin duct formation in Engelmann spruce.
  PloS one · 2026 · Davis TS, Khedive E, Hill E, et al.
  PMID 42133747DOI 10.1371/journal.pone.0349209
• Synergistic Regulation of Codonopsis pilosula Growth and Metabolism by Trichoderma, Salicylic Acid, and Methyl Jasmonate.
  Physiologia plantarum · 2026 · Huang S, Zhou K, Zhang H, et al.
  PMID 42120950DOI 10.1111/ppl.70919
• Effects of Trichoderma and salicylic acid/methyl jasmonate on the growth, development, and lipid metabolism of Codonopsis pilosula.
  Journal of plant physiology · 2026 · Gao P, Zhang H, Zhu N, et al.
  PMID 42096967DOI 10.1016/j.jplph.2026.154774
• Methyl 3-chloroasterric acid exerted anti-neuroinflammatory and antidepressant effects through the downregulation of P2Y1R.
  International immunopharmacology · 2026 · Zhang Y, Sun M, Zhang Z, et al.
  PMID 42055491DOI 10.1016/j.intimp.2026.116689
• The bZIP Transcription Factor PjbZIP1 Enhances Resistance to Powdery Mildew in Paeonia jishanensis by Directly Activating PjICS Involved in the SA Pathway.
  Physiologia plantarum · 2026 · Zhao XC, Li M, Niu JY, et al.
  PMID 42046456DOI 10.1111/ppl.70893
• PgWRKY44-mediated modulation of SA/JA pathways enhances blast pathogen resistance in pearl millet and rice.
  Plant signaling & behavior · 2026 · Saha B, Saha S, Kt M, et al.
  PMID 41935025DOI 10.1080/15592324.2026.2650899

The 10 most recently updated of 31 ClinicalTrials.gov registrations naming Methyl Salicylate as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Antiandrogen Therapy and Radiation Therapy With or Without Docetaxel in Treating Patients With Prostate Cancer That Has Been Removed by Surgery
  Completed · Phase 2 · Phase 3 · Interventional · 612 enrolled · NRG Oncology
  NCT03070886updated 2026-05-07
• Two Studies for Patients With Unfavorable Intermediate Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a Higher Gene Risk Score, The Guidance Trial
  Active not recruiting · Phase 3 · Interventional · 2,050 enrolled · NRG Oncology
  NCT05050084updated 2026-05-04
• Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial
  Active not recruiting · Phase 3 · Interventional · 2,753 enrolled · NRG Oncology
  NCT04513717updated 2026-05-04
• Counterpain PXM Versus Diclofenac Versus Piroxicam
  Completed · Phase 3 · Interventional · 180 enrolled · Taisho Pharmaceutical Indonesia
  NCT07475663updated 2026-03-16
• Impact of Cooling Mats on Vasomotor Symptoms in Patients Receiving Endocrine Therapy
  Enrolling by invitation · Interventional · 40 enrolled · Sligo General Hospital
  NCT07422727updated 2026-02-20
• Finite Androgen Ablation With or Without Abiraterone Acetate and Prednisone in Treating Patients With Recurrent Prostate Cancer
  Active not recruiting · Phase 2 · Interventional · 310 enrolled · M.D. Anderson Cancer Center
  NCT01786265updated 2026-02-20
• Antibacterial Mouthwash for Pharyngeal Gonorrhea Prevention
  Completed · Phase 2 · Interventional · 89 enrolled · University of California, Los Angeles
  NCT04966507updated 2026-02-13
• The Antiplaque and Antigingivitis Effect of Pure Green Tea Mouth Wash Compared to Placebo and Essential Oils Mouth Washes
  Recruiting · Interventional · 44 enrolled · King Abdullah University Hospital
  NCT07364565updated 2026-01-23
• Study of Gum Tissue Proteins in Smokers vs. Non-smokers After Cleaning
  Completed · Interventional · 36 enrolled · Al-Azhar University
  NCT07339670updated 2026-01-14
• Comparison Of Clinical Effects Of Listerine And Chlorhexidine Mouth Wash In Patients Undergoing Fixed Orthodontic Treatment
  Recruiting · Interventional · 60 enrolled · Khyber Medical University Peshawar
  NCT07119840updated 2025-11-26

Frequently asked questions

How does Methyl Salicylate work?

Mechanism-of-action classes: Cyclooxygenase Inhibitors; Prostaglandin Receptor Antagonists.

What is Methyl Salicylate used for?

According to FDA labeling, Methyl Salicylate carries indications including: Uses For the temporary relief of minor aches and pains of muscles and joints associated with: simple backache arthrits strains sprains. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Methyl Salicylate?

Methyl Salicylate is classified as Cyclooxygenase Inhibitors, Prostaglandin Receptor Antagonists, Decreased Prostaglandin Production, Decreased Thromboxane Production.

What are the brand names for Methyl Salicylate?

Methyl Salicylate is marketed under brand names including Arthricare for Women Pain Relieving Nighttime, Arthritis Hot Pain Relief, Atomic Balm, Castiva Cooling, Cramergesic, Dendracin Neurodendraxcin, Doloracin with Lidocaine, Dragon.