Methylcellulose

Mechanism-of-action class: Stool Bulking Activity.

• Uses • relieves constipation (irregularity) • helps to restore and maintain regularity • for treating bowel disorders when recommended by a doctor • generally provide effect in 12-72 hoursICD-10: K59.00

Directions • MIX THIS PRODUCT (CHILD OR ADULT DOSE) WITH AT LEAST 8 OUNCES (A FULL GLASS) OF WATER OR OTHER FLUID. TAKING THIS PRODUCT WITHOUT ENOUGH LIQUID MAY CAUSE CHOKING. SEE CHOKING WARNING • use product at the first sign of constipation or irregularity • put one dose in a full glass of cold water • stir briskly and drink promptly • drinking another glass of water is helpful Age Dose adults & children above 12 years of age and over one rounded tablespoon. (19 g) in 8 ounces of water fluid up to 3 times daily at the first sign of constipation or irregularity children 6 - 12 years of age half the adult dose in 8 ounces of water once daily. children under 6 years of age ask a doctor

CHOKING: taking this product without adequate fluid may cause it to swell and block your throat or esophagus and may cause choking. Do not take this product if you have difficulty in swallowing. If you experience chest pain, vomiting, or difficulty in swallowing or breathing after taking this product, seek immediate medical attention. Ask a doctor before use if you have • abdominal pain, nausea or vomiting • a sudden change in bowel habits that persists over a period of 2 weeks • sensitivity to any of the ingredients Stop use and ask a doctor if • you have rectal bleeding • you fail to have a bowl movement after use. • These could be signs of a serious condition. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away at 1-800-222-1222. When using this product • do not exceed recommended maximum daily dose unless directed by a doctor • do not use laxative products for a period longer than one week unless directed by a doctor

1. 1Nausea1908.4%
2. 2Diarrhoea1848.1%
3. 3Fatigue1797.9%
4. 4Drug Ineffective1506.6%
5. 5Constipation1366.0%
6. 6Dyspnoea1255.5%
7. 7Headache1175.2%
8. 8Dizziness1155.1%
9. 9Off Label Use1135.0%
10. 10Pain1124.9%
11. 11Asthenia1024.5%
12. 12Fall1004.4%
13. 13Arthralgia914.0%
14. 14Vomiting873.8%
15. 15Malaise843.7%

Recent PubMed references pinned to Methylcellulose as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Physical and biological synergistic strategies: injectable CNF/CMC hydrogels with cannabidiol@PCL microspheres for durable facial filling.
  Carbohydrate polymers · 2026 · Wang H, Chen G, Song R, et al.
  PMID 42173581DOI 10.1016/j.carbpol.2026.125376
• Development of active food packaging using carboxymethyl cellulose/gelatin composites reinforced with carbon quantum dots derived from pumpkin peel waste.
  Food research international (Ottawa, Ont.) · 2026 · Kavindi MAR, Nkede FN, Meng F, et al.
  PMID 42169305DOI 10.1016/j.foodres.2026.119344
• Innovative silver-salicylic acid nanoparticle coatings based on CMC and chitosan for mango (Mangifera indica L. cv. "Fajri Klan") fruit preservation.
  Scientific reports · 2026 · Hmmam I, Abdallatif A, Mamdouh BM, et al.
  PMID 42156462DOI 10.1038/s41598-026-52586-5
• Injectable photo-crosslinked hyaluronic acid/carboxymethyl cellulose hydrogel for the sustained delivery of rhFGF2 and accelerated wound healing.
  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2026 · Patrojanasophon P, Chidchai P, Opanasopit P, et al.
  PMID 42155814DOI 10.1016/j.ejps.2026.107559
• Multifunctional electrospun carboxymethyl cellulose-based composite nanofibers incorporating ZnO nanoparticles for enhanced wound healing.
  International journal of biological macromolecules · 2026 · Janani S, Khoshnevisan K, Kakhki NA, et al.
  PMID 42140295DOI 10.1016/j.ijbiomac.2026.152555
• Effects of different solvents on the physicochemical properties of gelatin/carboxymethyl cellulose/resveratrol electrospun nanofiber films.
  International journal of biological macromolecules · 2026 · Sun C, Wang YS, Cipriani JF, et al.
  PMID 42134703DOI 10.1016/j.ijbiomac.2026.152540
• Multifunctional zwitterionic hydrogel electrolyte based on sodium carboxymethylcellulose for 20% small tensile strain and its aqueous zinc-ion battery.
  International journal of biological macromolecules · 2026 · Bao W, Shao S, Sun S, et al.
  PMID 42114582DOI 10.1016/j.ijbiomac.2026.152437
• Multifunctional polyvinyl alcohol-sodium carboxymethyl cellulose/quercetin-ZnO nanofiber composites: Synergistic interplay of bioactivity, conductivity, and surface engineering.
  International journal of biological macromolecules · 2026 · Erol İ, İsmail İ, Hazman Ö, et al.
  PMID 42092652DOI 10.1016/j.ijbiomac.2026.152342

The 10 most recently updated of 250 ClinicalTrials.gov registrations naming Methylcellulose as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized Triple-Masked Controlled Clinical Trial
  Recruiting · Interventional · 180 enrolled · National Institute on Aging (NIA)
  NCT06274749updated 2026-06-12
• Safety, Tolerability, and Pharmacokinetics of MCAM in Healthy Adult Participants
  Not yet recruiting · Early phase 1 · Interventional · 24 enrolled · The University of Texas Health Science Center at San Antonio
  NCT07602335updated 2026-06-11
• Randomized Clinical Trial of Artificial Tears With and Without Preservatives in Patients With Dry Eye Disease
  Not yet recruiting · Phase 4 · Interventional · 80 enrolled · Pokhara Academy of Health Sciences, Western Regional Hospital
  NCT07635849updated 2026-06-10
• Psilocybin for Major Depressive Disorder (MDD)
  Active not recruiting · Phase 3 · Interventional · 238 enrolled · Usona Institute
  NCT06308653updated 2026-06-01
• Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST)
  Recruiting · Phase 2 · Interventional · 12 enrolled · Centre for Addiction and Mental Health
  NCT06512220updated 2026-06-01
• Fecal Microbiota Transplant for Anorexia Nervosa
  Not yet recruiting · Interventional · 20 enrolled · Hamilton Health Sciences Corporation
  NCT06593366updated 2026-05-27
• Feasibility, Clinical Effects, and Safety of Psilocybin-assisted Psychotherapy for Treatment-resistant OCD
  Enrolling by invitation · Phase 1 · Interventional · 10 enrolled · Centre for Addiction and Mental Health
  NCT06299319updated 2026-05-18
• Study on the Effectiveness and Safety of Two Olive Extract- Based (Olea Europea L. Folium) Supplements, Alone or Combined With a Mullein Extract (Verbascum Thapsus L. Herba Cum Floribus), for the Maintenance of Cognitive Function.
  Not yet recruiting · Interventional · 99 enrolled · ISTITUTO FARMOCHIMICO FITOTERAPICO: EPO SRL
  NCT07586410updated 2026-05-14
• Parasitic Ulcer Treatment Trial Pilot
  Completed · Phase 2 · Interventional · 49 enrolled · University of California, San Francisco
  NCT03484507updated 2026-05-07
• Eyelid Taping Alone Versus Taping With Lubricant Eye Drops for Perioperative Corneal Protection
  Not yet recruiting · Interventional · 200 enrolled · Fatih Sultan Mehmet Training and Research Hospital
  NCT07562594updated 2026-05-07

Frequently asked questions

How does Methylcellulose work?

Mechanism-of-action class: Stool Bulking Activity.

What is Methylcellulose used for?

According to FDA labeling, Methylcellulose carries indications including: Uses • relieves constipation (irregularity) • helps to restore and maintain regularity • for treating bowel disorders when recommended by a doctor • generally provide effect in 12-72 hours. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Methylcellulose?

Methylcellulose is classified as Bulk-forming laxatives, Stool Bulking Activity, Increased Large Intestinal Motility, Inhibition Large Intestine Fluid/Electrolyte Absorption.

What are the brand names for Methylcellulose?

Methylcellulose is marketed under brand names including Citrucel.