Nickel Sulfate

• PSORIZIDE ® Forte is indicated for the treatment of contact dermatitis due to nickel (metal/jewelry allergy,) dyshidrotic hand/foot eczema, and mild to severe psoriasis. It has been found to work well with a variety of combination therapies.ICD-10: L40.9

• Although there are no known contraindications, patients who are allergic to any PSORIZIDE ® Forte ingredient should consult a physician prior to taking the medication.contraindicated

Absorption of nickel sulphate is variable among individuals . For maximum absorption, tablets should be taken orally at the beginning of the day (or any convenient time after having taken nothing but water for at least 7 hours). Take nothing but water for one hour after taking medication to aid absorption. Weight Starting Dose Max Daily Dose 40-80 lbs ½ tablet 1 ½ tablet 80-120 lbs 1 tablet 3 tablets 120-160 lbs 1 ½ tablets 4 ½ tablets 160-200 lbs 2 tablets 6 tablets 200-240 lbs 2 ½ tablets 7 ½ tablets Over 240 lbs 3 tablets 9 tablets In the setting of renal impairment Dosage should be adjusted and serum nickel and bromide levels should be followed. Steady state trough level should be drawn prior to ingesting the day's dose after one week of dosing or at appropriate intervals. Target trough serum nickel level is 30-60 mcg/L. (Caution: post dose peak levels are unreliable.) Maintenance phase In order to maintain symptomatic relief, medication may be continued at the same or reduced initial phase dose level. Treatment duration depends on the individual. For allergic nickel dermatitis, continue 2 tablets 1 hour prior to breakfast for weeks 7 – 16. (Refer to Hypersensitivity section above). Some patients may require continued or intermittent repeated treatment to maintain nickel desensitization.

Do not use if imprinted seal under bottle cap is missing or broken. Do not use if pregnant or nursing. If allergic to nickel or metal objects such as jewelry, see PRECAUTIONS for hypersensitivity information. Lactose intolerant patients may have gastrointestinal difficulty. This has very rarely been reported at the doses used.

PSORIZIDE ® Forte contains low doses of active ingredients. Therefore there are minimal known side effects. (see PRECAUTIONS for hypersensitivity information)

Pregnancy Pregnancy category C Animal reproduction studies have not been conducted with PSORIZIDE ® Forte. PSORIZIDE ® Forte should not be given to a pregnant woman.

Fumaric acid toxicity The oral rat LD 50 is 9300mg/kg. 26 This is 3800 times the maximum dose recommended for PSORIZIDE ® Forte. Potassium bromide toxicity Indications of toxicity due to oral overdosage of bromide may include nausea and vomiting, apathy, disturbed coordination, loss of memory, drowsiness, loss of emotional control, agitation, hallucination, tremors, depressed reflexes, stupor, and coma. Acute toxic reactions in humans have been reported at doses as low as 1000mg. 31 This level is 67 times the dose received in one tablet of PSORIZIDE ® Forte. Nickel sulphate toxicity The oral rat LD 50 for nickel sulphate hexahydrate is 275mg/kg. 29 Symptoms of toxicity due to oral overdosage of nickel sulphate may include nausea, vomiting, abdominal discomfort, diarrhea, giddiness, lassitude, headaches, cough, and shortness of breath. 30 The lowest observed transitory toxic effects from human ingestion of soluble nickel salts is approximately 8 mg nickel/kg body weight. 30 This is 138 times the maximum dose recommended for PSORIZIDE ® Forte (see below).

Recent PubMed references pinned to Nickel Sulfate as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Mobility and environmental risk of potentially toxic elements (PTEs) in phosphogypsum-amended saline soils: an integrated soil-leachate assessment.
  Environmental geochemistry and health · 2026 · Mezlini W, Limonti C, Siciliano A, et al.
  PMID 42171794DOI 10.1007/s10653-026-03250-4
• Sodium Sulfate in the Li-Ion Battery Industry: Challenges, Opportunities, and Emerging Valorization Strategies.
  Environmental science & technology · 2026 · Tatad VYC, Tassel C, Olchowka J, et al.
  PMID 41933471DOI 10.1021/acs.est.5c17388
• Nickel ferrite-activated peroxydisulfate advanced oxidation process for enhanced sludge dewatering: performance evaluation and mechanism analysis.
  Environmental technology · 2026 · Chen Y, Xu W, He X, et al.
  PMID 41904936DOI 10.1080/09593330.2026.2648628
• Fluoride removal from NMC black mass leachates during Lithium-Ion battery recycling via aluminum sulfate precipitation.
  Waste management (New York, N.Y.) · 2025 · Aliyev A, Gray D, Bedrossian S, et al.
  PMID 40961815DOI 10.1016/j.wasman.2025.115136
• Green collaborative recycling of spent NCM cathode and waste sodium sulfate via an unconventional process.
  Waste management (New York, N.Y.) · 2025 · Gao X, Gu K, Cui X, et al.
  PMID 40961814DOI 10.1016/j.wasman.2025.115133
• Simultaneous recovery of valuable components from spent LiNi(0.6)Co(0.2)Mn(0.2)O(2) and LiFePO(4) batteries by ammonium sulfate roasting-leaching.
  Waste management (New York, N.Y.) · 2025 · Li G, Zhang G, Li J, et al.
  PMID 40782494DOI 10.1016/j.wasman.2025.115051
• Sulfate reducing bacteria corrosion of a 90/10 Cu-Ni alloy coupled to an Al sacrificial anode.
  Bioelectrochemistry (Amsterdam, Netherlands) · 2025 · Qian H, Wang T, Xu P, et al.
  PMID 39742711DOI 10.1016/j.bioelechem.2024.108892
• Experimental formation of carbonates from perchlorate and sulphate brines: Implications for Jezero crater, Mars.
  PloS one · 2024 · Escamilla-Roa E, Martin-Torres J, Zorzano MP, et al.
  PMID 39637075DOI 10.1371/journal.pone.0312495

The 5 most recently updated of 5 ClinicalTrials.gov registrations naming Nickel Sulfate as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• The Immunological Profile of Nickel Dermatitis
  Completed · Interventional · 26 enrolled · National Allergy Research Center, Denmark
  NCT04438330updated 2023-01-04
• Study of the Intradermal Injection of rHuPH20 or Placebo in Participants With Nickel Allergic Contact Dermatitis
  Completed · Phase 2 · Interventional · 22 enrolled · Halozyme Therapeutics
  NCT00928447updated 2021-12-17
• Clinical Evaluation of T.R.U.E. Test Allergens in Children an Adolescents
  Completed · Interventional · 116 enrolled · Allerderm
  NCT01797562updated 2020-08-21
• Quality of Life in Systemic Nickel Allergy Syndrome
  Completed · Observational · 52 enrolled · Catholic University of the Sacred Heart
  NCT03731494updated 2020-02-05
• Assess Itch Behavior in Nickel Sulphate Sensitized Volunteers
  Completed · Phase 1 · Interventional · 18 enrolled · Fundacion IMIM
  NCT01529320updated 2016-05-12

Frequently asked questions

What is Nickel Sulfate used for?

According to FDA labeling, Nickel Sulfate carries indications including: PSORIZIDE ® Forte is indicated for the treatment of contact dermatitis due to nickel (metal/jewelry allergy,) dyshidrotic hand/foot eczema, and mild to severe psoriasis. It has been found to work well with a variety of combination therapies.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What are the contraindications for Nickel Sulfate?

Nickel Sulfate labeling lists contraindications including: Although there are no known contraindications, patients who are allergic to any PSORIZIDE ® Forte ingredient should consult a physician prior to taking the medication.. Always consult the full prescribing information and a clinician.