Nitric Oxide

Mechanism-of-action classes: Guanylate Cyclase Activators; Nitric Oxide Donors.

Administration of this gas mixture may be hazardous or contraindicated. For use only by or under the supervision of a licensed practitioner who is experienced in the use and administration of gas mixtures, and if familiar with the indications, effects, dosages, methods, and frequency and duration of administration, and with the hazards, contraindications and side effects and the precautions to be taken.

• Dec 23, 1999NDANDA020845Mallinckrodt Ireland
• Oct 2, 2018ANDAANDA207141Vero Biotech Inc
• Dec 20, 2019NDANDA202860Vero Biotech Inc
• Jul 27, 2023ANDAANDA203144Airgas Therap

1. 1No Adverse Event78918%
2. 2Device Malfunction61214%
3. 3Device Issue44010%
4. 4Underdose4289.9%
5. 5Death3818.8%
6. 6Product Use Issue3518.1%
7. 7Off Label Use3357.7%
8. 8Drug Ineffective3167.3%
9. 9Oxygen Saturation Decreased2636.1%
10. 10Product Use In Unapproved Indication2004.6%
11. 11Condition Aggravated1824.2%
12. 12Device Failure1463.4%
13. 13Respiratory Failure1413.2%
14. 14Hypotension1393.2%
15. 15Pulmonary Hypertension1393.2%

Recent PubMed references pinned to Nitric Oxide as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Nitric Oxide and Hydrogen Sulfide Crosstalk in Plants: Redox Regulation, Stress Adaptation, and Emerging Applications.
  International journal of molecular sciences · 2026 · Dos Reis RA, Seabra AB, Aragão CB, et al.
  PMID 42278488DOI 10.3390/ijms27114962
• Circadian-Related Serotonin/Melatonin Level Modulates Cisplatin Ototoxicity Susceptibility Depended on NOS3-NO Pathway.
  Journal of pineal research · 2026 · Qiu S, Cai S, Xie R, et al.
  PMID 42262169DOI 10.1111/jpi.70154
• Visualization of hepatic fibrosis and assessment of therapeutic effect by an asymmetric BODIPY fluorescent probe capable of dually detecting lipid droplets and nitric oxide.
  Analytica chimica acta · 2026 · Wu Y, Li L, Chen L, et al.
  PMID 42242811DOI 10.1016/j.aca.2026.345670
• Excess nitric oxide alters cellular pH to restrict salicylic acid movement and systemic immunity.
  Science advances · 2026 · Xia F, Liu H, Yu K, et al.
  PMID 42213848DOI 10.1126/sciadv.adz4776
• Simultaneous CO(2) and NO Conversion by Spatially Locating Dual Photocatalytic Sites on a Microporous Polymer.
  Environmental science & technology · 2026 · Cui G, Wang H, Ma Y, et al.
  PMID 42205038DOI 10.1021/acs.est.5c18558
• Integrated transcriptomic and proteomic profiling implicates prostaglandin-nitric oxide network dysregulation in uterine microcirculatory impairment in primary dysmenorrhea.
  Frontiers in immunology · 2026 · Li Y, Yang Z, Yu B, et al.
  PMID 42199425DOI 10.3389/fimmu.2026.1833346
• Nitric oxide dual-enhanced nanosystem boosts ferroptosis-chemotherapy synergy for tumor therapy.
  Scientific reports · 2026 · Ding X, Ren J, Li D, et al.
  PMID 42192119DOI 10.1038/s41598-026-51184-9
• [Use of inhaled nitric oxide during neonatal transport - a review of seven years of experience].
  Orvosi hetilap · 2026 · Lantos L, Somogyvári Z, Széll A, et al.
  PMID 42177754DOI 10.1556/650.2026.33539

The 10 most recently updated of 926 ClinicalTrials.gov registrations naming Nitric Oxide as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• L-Citrulline and Tadalafil for Mild to Moderate Erectile Dysfunction
  Recruiting · Phase 4 · Interventional · 133 enrolled · Beni-Suef University
  NCT07642505updated 2026-06-12
• Key Diagnostic & Therapeutic Technologies for Severe Acute High Altitude Disease (SAHAD): Integration and Application
  Not yet recruiting · Interventional · 3,035 enrolled · Tibet Autonomous Region People's Hospital
  NCT07639931updated 2026-06-10
• Endothelial Dysfunction and Nitric Oxyde During Laparoscopic Surgery
  Completed · Interventional · 40 enrolled · Alexander Averyanov
  NCT07638124updated 2026-06-10
• Role of Genetic Factors in the Development of Lung Disease
  Recruiting · Observational · 3,500 enrolled · National Heart, Lung, and Blood Institute (NHLBI)
  NCT00001532updated 2026-06-08
• Natural History of Sickle Cell Disease
  Recruiting · Observational · 3,500 enrolled · National Heart, Lung, and Blood Institute (NHLBI)
  NCT00081523updated 2026-06-08
• Nitrate, Exercise and Vascular Function in Midlife Women
  Recruiting · Interventional · 54 enrolled · University of Vienna
  NCT06527248updated 2026-06-05
• Oral Sildenafil for Exercise Capacity, Dyspnea and Cardiopulmonary Function in COPD
  Recruiting · Phase 2 · Interventional · 160 enrolled · University of Alberta
  NCT05061368updated 2026-06-04
• Evaluation of Adding Nitrate Into Foods for Regulating Nitric Oxide Bioavailability in Healthy Individuals
  Recruiting · Interventional · 30 enrolled · Queen Mary University of London
  NCT07172425updated 2026-06-04
• The Effect of Inhaled Nitric Oxide on Pulmonary Gas-exchange in COPD
  Not yet recruiting · Phase 1 · Phase 2 · Interventional · 80 enrolled · University of Alberta
  NCT04231760updated 2026-06-04
• Characterisation of Functional and Cognitive Responses Following Olfactory Stimulation and/or Functional Training in Older Adults.
  Completed · Interventional · 120 enrolled · Fundacion Miguel Servet
  NCT07623122updated 2026-06-03

Frequently asked questions

How does Nitric Oxide work?

Mechanism-of-action classes: Guanylate Cyclase Activators; Nitric Oxide Donors.

What class of drug is Nitric Oxide?

Nitric Oxide is classified as Other respiratory system products, Vasodilator, Guanylate Cyclase Activators, Nitric Oxide Donors, Pulmonary Arterial Vasodilation, Vasodilation.

What are the brand names for Nitric Oxide?

Nitric Oxide is marketed under brand names including INOmax, Noxivent, Ulspira.