Norwalk Virus

• For the temporary relief of nausea or vomiting, abdominal pain or cramps, diarrhea, muscle pain, or feelings of discomfort or uneasiness.*ICD-10: R11.2

DIRECTIONS Place drops under tongue 30 minutes before/after meals. Adults and children 12 years and over: Take 10 to 15 drops once weekly or monthly. If mild symptoms are present, take 10 drops up to 3 times per day. Consult a physician for use in children under 12 years of age.

Consult a doctor if condition worsens or if symptoms persist. Keep out of the reach of children. In case of overdose, get medical help or contact a poison control center right away. If pregnant or breastfeeding, ask a healthcare professional before use. Keep out of the reach of children. If pregnant or breastfeeding, ask a healthcare professional before use.

Recent PubMed references pinned to Norwalk Virus as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Norovirus strains among children aged 0-18 years hospitalized with acute gastroenteritis in Estonia 2015-2016.
  Journal of medical virology · 2022 · Kõivumägi K, Geller J, Toompere K, et al.
  PMID 34854093DOI 10.1002/jmv.27495
• Less severe clinical symptoms of Norwalk virus 8fIIb inoculum compared to its precursor 8fIIa from human challenge studies.
  Journal of medical virology · 2021 · Liu P, Rahman M, Leon J, et al.
  PMID 33017074DOI 10.1002/jmv.26578
• Virucidal activity of three ethanol-based hand rubs against murine norovirus in a hand hygiene clinical simulation study.
  Future microbiology · 2020 · Eggers M, Benzinger C, Suchomel M, et al.
  PMID 32960094DOI 10.2217/fmb-2020-0168
• Production and Clinical Evaluation of Norwalk GI.1 Virus Lot 001-09NV in Norovirus Vaccine Development.
  The Journal of infectious diseases · 2020 · Mateo R, Lindesmith LC, Garg SJ, et al.
  PMID 31628848DOI 10.1093/infdis/jiz540
• Immunoinformatics approaches for designing a novel multi epitope peptide vaccine against human norovirus (Norwalk virus).
  Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2019 · Azim KF, Hasan M, Hossain MN, et al.
  PMID 31233780DOI 10.1016/j.meegid.2019.103936
• Selection and Characterization of Rupintrivir-Resistant Norwalk Virus Replicon Cells In Vitro.
  Antimicrobial agents and chemotherapy · 2018 · Kitano M, Hosmillo M, Emmott E, et al.
  PMID 29530860DOI 10.1128/AAC.00201-18
• Mapping and modeling of a strain-specific epitope in the Norwalk virus capsid inner shell.
  Virology · 2016 · Parra GI, Sosnovtsev SV, Abente EJ, et al.
  PMID 26971245DOI 10.1016/j.virol.2016.02.019
• Immunogenicity of Newcastle disease virus vectors expressing Norwalk virus capsid protein in the presence or absence of VP2 protein.
  Virology · 2015 · Kim SH, Chen S, Jiang X, et al.
  PMID 26099695DOI 10.1016/j.virol.2015.06.003

The 8 most recently updated of 8 ClinicalTrials.gov registrations naming Norwalk Virus as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Norovirus Challenge Study
  Completed · Phase 1 · Phase 2 · Interventional · 165 enrolled · Vaxart
  NCT05212168updated 2025-11-05
• Evaluation of Infectivity and Illness of Norwalk GI.1 Virus Lot 001-09NV in the Human Challenge Model
  Completed · Phase 1 · Interventional · 16 enrolled · WCCT Global
  NCT03721549updated 2020-01-22
• Norovirus Bivalent-Vaccine Efficacy Study
  Completed · Phase 1 · Phase 2 · Interventional · 132 enrolled · Takeda
  NCT01609257updated 2019-01-09
• Norwalk Vaccine Study
  Completed · Phase 1 · Phase 2 · Interventional · 98 enrolled · Takeda
  NCT00973284updated 2017-08-08
• Phase 1 Norwalk Vaccine Study
  Completed · Phase 1 · Interventional · 61 enrolled · LigoCyte Pharmaceuticals, Inc.
  NCT00806962updated 2015-05-06
• New Challenge Pool of Norwalk Virus Inoculum
  Completed · Phase 1 · Interventional · 57 enrolled · National Institute of Allergy and Infectious Diseases (NIAID)
  NCT00138476updated 2014-05-09
• Infectivity of Norovirus in Shellfish Treated With High Hydrostatic Pressure Processing-Human Challenge Study
  Completed · Interventional · 51 enrolled · Emory University
  NCT00674336updated 2013-11-19
• Infectivity of Norovirus in Groundwater-Human Challenge Study
  Completed · Interventional · 13 enrolled · Emory University
  NCT00313404updated 2013-11-19

Frequently asked questions

What is Norwalk Virus used for?

According to FDA labeling, Norwalk Virus carries indications including: For the temporary relief of nausea or vomiting, abdominal pain or cramps, diarrhea, muscle pain, or feelings of discomfort or uneasiness.*. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.