Oleate

• ETHAMOLIN Injection is indicated for the treatment of patients with esophageal varices that have recently bled, to prevent rebleeding. ETHAMOLIN is not indicated for the treatment of patients with esophageal varices that have not bled.

• ETHAMOLIN Injection should not be administered to subjects with a known hypersensitivity to ethanolamine, oleic acid, or ethanolamine oleate.contraindicated

Local ETHAMOLIN Injection sclerotherapy of esophageal varices should be performed by physicians who are famillar with an acceptable technique. The usual intravenous dose is 1.5 to 5.0 mL per varix. The maximum dose per treatment session should not exceed 20 mL. Patients with significant liver dysfunction (Child Class C) or concomitant cardiopulmonary disease should usually receive less than the recommended maximum dose. Submucosal injections are not recommended as they reportedly are more likely to result in ulceration at the site of injection. To obliterate the varix, injections may be made at the time of the acute bleeding episode and then after one week, six weeks, three months, and six months, as indicated. Note: Parenteral drug products should be inspected visually for particulate matter and discoloration before administration whenever solution and container permit.

ETHAMOLlN Injection should be used in pregnant women only when clearly needed (see PRECAUTIONS). The practice of injecting varicosities of the leg with ETHAMOLlN Injection is not supported by adequately controlled clinical trials. Therefore, such use is not recommended.

The reported frequency of complications/adverse events per injection session was 13%. The most common complications were pleural effusion/infiltration (2.1%), esophageal ulcer (2.1 %), pyrexia (1.8%), retrosternal pain (1.6%), esophageal stricture (1.3%), and pneumonia (1.2%). Other adverse local esophageal reactions have also been reported at rates of 0.1 to 0.4%, including esophagitis, tearing of the esophagus, sloughing of the mucosa overlying the injected varix, ulceration, stricture, necrosis, periesophageal abscess and perforation (see PRECAUTIONS). These complications appear to be dependent upon the dose and the patient's clinical state. Bacteremia has been observed in patients following injection of esophageal varices with ETHAMOLlN. Pyrexia and retrosternal pain are not infrequently observed during the post-injection period. Fatal aspiration pneumonia has occurred in patients with esophageal varices who underwent ETHAMOLIN Injection Sclerotherapy (see PRECAUTIONS). Anaphylactic shock and acute renal failure with spontaneous recovery have occurred (see PRECAUTIONS). A case of disseminated intravascular coagulation has been reported. Spinal cord paralysis due to occlusion of the anterior spinal artery has been reported in one child eight hours after ETHAMOLIN sclerotherapy.

Pregnancy: (Teratogenic Effects: Pregnancy Category C) Animal reproduction studies have not been conducted with ETHAMOLlN Injection. It is also not known whether ETHAMOLIN Injection can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. ETHAMOLIN Injection should be given to a pregnant woman only if clearly needed.

Overdosage of ETHAMOLIN Injection can result in severe intramural necrosis of the esophagus. Complications resulting from such overdosage have resulted in death.

• Dec 22, 1988NDANDA019357Qol Medcl

1. 1Oesophageal Varices Haemorrhage528%
2. 2Portal Vein Thrombosis317%
3. 3Product Use In Unapproved Indication317%
4. 4Off Label Use211%
5. 5Abdominal Pain15.6%
6. 6Abdominal Pain Upper15.6%
7. 7Anaemia15.6%
8. 8Arterial Haemorrhage15.6%
9. 9Ascites15.6%
10. 10Cataract15.6%
11. 11Disseminated Intravascular Coagulation15.6%
12. 12Dry Eye15.6%
13. 13Essential Thrombocythaemia15.6%
14. 14Gastrointestinal Ischaemia15.6%
15. 15Haemorrhagic Ascites15.6%

Recent PubMed references pinned to Oleate as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Tocilizumab and Dexamethasone Reduce TNF-α and IL-33 and Oxidative Stress in Kidney Tissue in Oleic Acid-Induced ARDS Model.
  Journal of biochemical and molecular toxicology · 2026 · Erol HS, Demirci B, Alhilal M, et al.
  PMID 42231606DOI 10.1002/jbt.70947
• Oleic Acid Levels in HSA(LR) Mouse Model of Myotonic Dystrophy Type 1.
  International journal of molecular sciences · 2026 · Peris-Moreno D, Sabater-Arcis M, Moreno N, et al.
  PMID 42196193DOI 10.3390/ijms27104211
• The role of growth differentiation factor 15 in the polarization and foaming of THP-1 macrophages induced by trans fatty acids from different sources.
  Toxicology in vitro : an international journal published in association with BIBRA · 2026 · Lin J, Fang W, Yuan Y, et al.
  PMID 42191097DOI 10.1016/j.tiv.2026.106253
• Palmitic and oleic acids induce macrophage foam cell formation through C/EBPβ activation.
  Frontiers in immunology · 2026 · Wang G, Zhu Y, Liu Y, et al.
  PMID 42136674DOI 10.3389/fimmu.2026.1809059
• Oleic acid modification enables lysosomal escape of phthalocyanine photosensitizer for effective bladder cancer treatment.
  Bioorganic & medicinal chemistry · 2026 · Cui A, Liu H, Wang K, et al.
  PMID 42119332DOI 10.1016/j.bmc.2026.118701
• Finite element modelling for elucidating surface topography influence on cell-substrate interaction on fatty acid-modified PCL substrate.
  Journal of biomechanics · 2026 · Ganguly R, Choudhury S, Gupta A, et al.
  PMID 42114253DOI 10.1016/j.jbiomech.2026.113353
• Oleic Acid and Transferrin Synergistically Induce Serum-Free Adipogenic Differentiation of Porcine Preadipocytes via the SEPTIN4/PPARγ Axis.
  Cells · 2026 · Fu Z, Li Y, Wang S, et al.
  PMID 42041552DOI 10.3390/cells15080684
• Oleic acid fuels cisplatin-resistant ovarian cancer through FABP4-driven lipid uptake.
  Molecular metabolism · 2026 · Isac AM, Valdivia A, Zha D, et al.
  PMID 42025693DOI 10.1016/j.molmet.2026.102374

The 10 most recently updated of 120 ClinicalTrials.gov registrations naming Oleate as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Omega-3 Fatty Acids for Smoking Cessation in Pregnancy
  Completed · Phase 2 · Interventional · 237 enrolled · Vanderbilt University Medical Center
  NCT04417595updated 2026-06-04
• Complications of Ethanol-amine Oleate Intralesional Sclerotherapy
  Completed · Observational · 15 enrolled · Suez Canal University
  NCT04930952updated 2026-05-13
• The Healthy Cookie Study: Understanding How Healthy Cookies Affect Fat in the Blood,
  Active not recruiting · Interventional · 123 enrolled · Ohio State University
  NCT02841618updated 2026-04-21
• The Foods & Oil to Repair, Correct and Enhance Strength (FORCES) Study
  Recruiting · Interventional · 66 enrolled · Ohio State University
  NCT06361511updated 2026-04-21
• To Test a New Drug (LCFA-01) for Safety and PK in Healthy Adults for Bacterial Vaginosis Infection.
  Not yet recruiting · Phase 1 · Interventional · 30 enrolled · Massachusetts General Hospital
  NCT07514416updated 2026-04-07
• DMAE Oleate for Facial Skin Firmness and Fine Lines in Healthy Adults
  Completed · Interventional · 30 enrolled · Bionos Biotech S.L.
  NCT07255560updated 2026-01-30
• Nutritional Oleic Acid Modulation of adIpose Cholesterol Metabolism in Patients Living With Obesity
  Recruiting · Interventional · 40 enrolled · Nantes University Hospital
  NCT07027033updated 2026-01-15
• Study of Single Oral Doses of HOPO 14-1 Evaluating Safety, Tolerability, Pharmacokinetics
  Completed · Phase 1 · Interventional · 42 enrolled · SRI International
  NCT05628961updated 2025-11-14
• Flublok or Fluzone With Advax-CpG55.2 or AF03
  Completed · Phase 1 · Interventional · 241 enrolled · National Institute of Allergy and Infectious Diseases (NIAID)
  NCT03945825updated 2025-10-14
• Fatty Acid Modulation of Brain Function in Older Adults
  Recruiting · Interventional · 60 enrolled · University of Vermont
  NCT06192407updated 2025-09-17

Frequently asked questions

What is Oleate used for?

According to FDA labeling, Oleate carries indications including: ETHAMOLIN Injection is indicated for the treatment of patients with esophageal varices that have recently bled, to prevent rebleeding. ETHAMOLIN is not indicated for the treatment of patients with esophageal varices that have not bled.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What are the contraindications for Oleate?

Oleate labeling lists contraindications including: ETHAMOLIN Injection should not be administered to subjects with a known hypersensitivity to ethanolamine, oleic acid, or ethanolamine oleate.. Always consult the full prescribing information and a clinician.