pharmacopeia
GET
/api/v1/drug/orlistat

Mechanism of action

Sourced from openFDA

Mechanism-of-action class: Lipase Inhibitors.

Lipase

Indications

Sourced from openFDA
  • Use for weight loss in overweight adults, 18 years and older, when used along with a reduced-calorie and low-fat diet

Dosage & administration

Sourced from openFDA

Directions read the enclosed brochure for other important information diet and exercise are the starting points for any weight loss program. Try these first before adding orlistat. Check with your doctor before starting any exercise program. to see if orlistat capsules are right for you, find your height on the chart to the right. You may consider starting a weight loss program with orlistat if your weight is the same or more than the weight shown for your height. for overweight adults 18 years and older: take 1 capsule with each meal containing fat do not take more than 3 capsules daily use with a reduced-calorie, low-fat diet and exercise program until you reach your weight loss goal. Most weight loss occurs in the first 6 months. if you stop taking orlistat, continue with your diet and exercise program if you start to regain weight after you stop taking orlistat, you may need to start taking orlistat again along with your diet and exercise program take a multivitamin once a day, at bedtime, when using orlistat Ht. / Wt. 4’10” 129 lbs. 4’11” 133 lbs. 5’0” 138 lbs. 5’1” 143 lbs. 5’2” 147 lbs. 5’3” 152 lbs. 5’4” 157 lbs. 5’5” 162 lbs. 5’6” 167 lbs. 5’7” 172 lbs. 5’8” 177 lbs. 5’9” 182 lbs. 5’10” 188 lbs. 5’11” 193 lbs. 6’0” 199 lbs. 6’1” 204 lbs. 6’2” 210 lbs. 6’3” 216 lbs. 6’4” 221 lbs. 6’5” 227 lbs.

Warnings & precautions

Sourced from openFDA

Organ transplant alert: do not use if you have had an organ transplant. Orlistat interferes with the medicines used to prevent transplant rejection. Allergy alert: do not use if you are allergic to any of the ingredients in orlistat capsules Do not use if you are taking cyclosporine if you have been diagnosed with problems absorbing food if you are not overweight Ask a doctor before use if you have ever had gallbladder problems kidney stones pancreatitis Ask a doctor or pharmacist before use if you are taking any of the following prescription medications. Some prescription doses may need to be adjusted, or some medications may not work as well when used with orlistat. anticoagulants (blood thinning medicine) amiodarone (heart medicine) diabetes medicine thyroid disease medicine seizure medicine antiretrovirals (HIV medicine) taking any other weight loss products When using this product take a multivitamin once a day, at bedtime . Orlistat can reduce the absorption of some vitamins. follow a well-balanced, reduced-calorie, low-fat diet. Try starting this diet before taking orlistat. orlistat works by preventing the absorption of some of the fat you eat. The fat passes out of your body, so you may have bowel changes. You may get: gas with oily spotting loose stools more frequent stools that may be hard to control eating a low-fat diet lowers the chance of having these bowel changes for every 5 pounds you lose from diet alone, orlistat can help you lose 2-3 pounds more. In studies, most people lost 5-10 pounds over 6 months.

Approval history

Sourced from openFDA
  • Apr 23, 1999NDANDA020766Cheplapharm
  • Feb 7, 2007NDANDA021887Haleon Us Holdings

FAERS reports

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Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
25,681 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
  1. 1Drug Ineffective4,52418%
  2. 2Rectal Discharge2,4329.5%
  3. 3Gastrointestinal Disorder2,1858.5%
  4. 4Constipation1,9917.8%
  5. 5Diarrhoea1,9527.6%
  6. 6Weight Increased1,9447.6%
  7. 7Steatorrhoea1,6476.4%
  8. 8Flatulence1,6176.3%
  9. 9Abdominal Pain Upper1,3665.3%
  10. 10Headache1,1134.3%
  11. 11Abdominal Distension1,0053.9%
  12. 12Nausea9473.7%
  13. 13Treatment Noncompliance8053.1%
  14. 14Malaise7823.0%
  15. 15Abdominal Pain6932.7%

Literature

View JSON

Recent PubMed references pinned to Orlistat as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

Clinical trials

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The 10 most recently updated of 83 ClinicalTrials.gov registrations naming Orlistat as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

Frequently asked questions

How does Orlistat work?
Mechanism-of-action class: Lipase Inhibitors.
What is Orlistat used for?
According to FDA labeling, Orlistat carries indications including: Use for weight loss in overweight adults, 18 years and older, when used along with a reduced-calorie and low-fat diet. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
What class of drug is Orlistat?
Orlistat is classified as Peripherally acting antiobesity products, Intestinal Lipase Inhibitor, Lipase Inhibitors, Inhibition Fat Digestion.
What are the brand names for Orlistat?
Orlistat is marketed under brand names including Alli, Xenical.
Note. Data for orlistat is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.

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