Ornithine Alpha-ketoglutarate

• Uses: Temporarily supports the body to rebalance Human Growth Hormone (HGH) output.

Directions: Adults: Hold the spray-top close to your open mouth and spray twice directly under your tongue, three times a day. Some people notice improvement within two or three weeks, others take longer.

Not for use on children. If symptoms continue to recur, or if sleeplessness persists continuously for more than two weeks, consult a physician. As with all medicines, if you are pregnant or breast feeding , consult a heatlh professional before using this product. Keep out of reach of children . In case of overdose, get medical or contact a Poison Control Center right away. Keep out of reach of children.

Recent PubMed references pinned to Ornithine Alpha-ketoglutarate as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Metabolic and Immunomodulatory Effects of α-Ketoglutarate in Burn Injuries: A Systematic Review.
  Journal of burn care & research : official publication of the American Burn Association · 2026 · Niederegger T, Munzinger R, Schaschinger T, et al.
  PMID 41504365DOI 10.1093/jbcr/irag002
• Branched-chain amino acid supplementation in treatment of liver cirrhosis: Updated views on how to attenuate their harmful effects on cataplerosis and ammonia formation.
  Nutrition (Burbank, Los Angeles County, Calif.) · 2017 · Holeček M
  PMID 28760433DOI 10.1016/j.nut.2017.04.003
• Characterization of molecular associations involving L-ornithine and α-ketoglutaric acid: crystal structure of L-ornithinium α-ketoglutarate.
  Annales pharmaceutiques francaises · 2014 · Allouchi H, Céolin R, Berthon L, et al.
  PMID 24997885DOI 10.1016/j.pharma.2014.04.005
• Alpha-ketoglutarate (AKG) inhibits proliferation of colon adenocarcinoma cells in normoxic conditions.
  Scandinavian journal of gastroenterology · 2012 · Rzeski W, Walczak K, Juszczak M, et al.
  PMID 22486188DOI 10.3109/00365521.2012.660539
• Urinary 2-hydroxy-5-oxoproline, the lactam form of α-ketoglutaramate, is markedly increased in urea cycle disorders.
  Analytical and bioanalytical chemistry · 2011 · Kuhara T, Inoue Y, Ohse M, et al.
  PMID 21298421DOI 10.1007/s00216-011-4688-x
• Effect of ornithine alpha-ketoglutarate on glutamine pools in burn injury: evidence of component interaction.
  Intensive care medicine · 2007 · Cynober L, Lasnier E, Le Boucher J, et al.
  PMID 17235510DOI 10.1007/s00134-006-0511-0
• Coadministration of ornithine and alpha-ketoglutarate is no more effective than ornithine alone as an arginine precursor in piglets enterally fed an arginine-deficient diet.
  The Journal of nutrition · 2007 · Urschel KL, Wilkinson CW, Pencharz PB, et al.
  PMID 17182801DOI 10.1093/jn/137.1.55
• Does the ornithine-alpha-ketoglutarate ratio influence ornithine alpha-ketoglutarate metabolism in healthy rats?
  Metabolism: clinical and experimental · 2007 · Loï C, Hamani D, Moinard C, et al.
  PMID 17161232DOI 10.1016/j.metabol.2006.09.004

The 1 most recently updated of 1 ClinicalTrials.gov registrations naming Ornithine Alpha-ketoglutarate as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Anaplerotic Therapy in Propionic Acidemia
  Completed · Phase 1 · Interventional · 3 enrolled · Nicola Longo
  NCT00645879updated 2015-01-21

Frequently asked questions

What is Ornithine Alpha-ketoglutarate used for?

According to FDA labeling, Ornithine Alpha-ketoglutarate carries indications including: Uses: Temporarily supports the body to rebalance Human Growth Hormone (HGH) output.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Ornithine Alpha-ketoglutarate?

Ornithine Alpha-ketoglutarate is classified as Liver therapy.