Oxybenzone

Mechanism-of-action class: Physiochemical Activity.

• Uses Helps prevent sunburn

Directions For suncreen use Apply liberally 15 minutes before sun exposure Use a water resistant sunscreen if swimming or sweating or washing Reapply at least every 2 hours Spending time in the sun increases your risk of skin cancer and early skin aging. Sun Protection Measures. To decrease this risk, regularly use a sunscreen with a broad spectrum SPF of 15 or higher and other sun protection measures including: limit time in the sun, especially from 10 a.m. – 2 p.m. wear long-sleeve shirts, pants, hats, and sunglasses Children under 6 months: ask a doctor

For external use only Do not use on broken or damaged skin When using this product keep out of eyes. Rinse with water to remove. Stop use and ask a doctor if rash occurs Keep out of reach of children. If product is swallowed, get medical help or contact a Poison Control Center right away.

1. 1Rash405.8%
2. 2Skin Cancer385.5%
3. 3Sunburn385.5%
4. 4Drug Ineffective375.3%
5. 5Pruritus334.8%
6. 6Pain263.8%
7. 7Erythema243.5%
8. 8Fatigue243.5%
9. 9Dyspnoea233.3%
10. 10Headache233.3%
11. 11Circumstance Or Information Capable Of Leading To Medication Error213.0%
12. 12Malignant Melanoma213.0%
13. 13Product Expiration Date Issue213.0%
14. 14Product Use Issue213.0%
15. 15Basal Cell Carcinoma192.7%

The 9 most recently updated of 9 ClinicalTrials.gov registrations naming Oxybenzone as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Weight Loss and Endocrine Disrupting Chemicals (EDCs): Lifestyle Interventions to Lose Weight and Reduce EDC Exposure in Individuals With Overweight/Obesity
  Active not recruiting · Interventional · 226 enrolled · Million Marker Wellness, Inc.
  NCT07560579updated 2026-05-19
• A Personalized Biomonitoring and Report-back Intervention to Reduce Exposure to Endocrine Disrupting Chemicals
  Active not recruiting · Interventional · 600 enrolled · Million Marker Wellness, Inc.
  NCT06450951updated 2026-05-14
• Clinical Study to Evaluate the 80-Minute Water Resistant Sun Protection Factor (SPF) of Sunscreen Products
  Completed · Interventional · 15 enrolled · HALEON
  NCT05124899updated 2024-04-26
• Clinical Study to Evaluate the Sun Protection Factor (SPF) of Three Sunscreen Products
  Completed · Interventional · 13 enrolled · HALEON
  NCT05109104updated 2024-04-19
• Clinical Study to Evaluate the Sun Protection Factor (SPF) of Sunscreen Products
  Completed · Interventional · 11 enrolled · HALEON
  NCT05085327updated 2024-03-25
• Assessment of the Human Systemic Absorption of Sunscreen Ingredients
  Completed · Phase 1 · Interventional · 72 enrolled · Food and Drug Administration (FDA)
  NCT03582215updated 2020-04-21
• A Sunscreen Based on Bioadhesive Nanoparticles
  Completed · Phase 1 · Interventional · 13 enrolled · Yale University
  NCT02668536updated 2018-03-13
• Ultraviolet and UV-Visible Light Photoprotection for the Treatment of Melasma
  Completed · Phase 4 · Interventional · 68 enrolled · Universidad Autonoma de San Luis Potosí
  NCT01695356updated 2014-12-02
• Multi-Centre European Photopatch Test Study
  Completed · Interventional · 1,000 enrolled · NHS Tayside
  NCT00530387updated 2011-08-04

Frequently asked questions

How does Oxybenzone work?

Mechanism-of-action class: Physiochemical Activity.

What is Oxybenzone used for?

According to FDA labeling, Oxybenzone carries indications including: Uses Helps prevent sunburn. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Oxybenzone?

Oxybenzone is classified as Physiochemical Activity, Sunscreening Activity.