Phenyl Salicylate

Mechanism-of-action class: Cyclooxygenase Inhibitors.

• Uribel Tabs are indicated for the treatment of symptoms of irritative voiding. Indicated for the relief of local symptoms, such as inflammation, hypermotility, and pain, which accompany lower urinary tract infections.ICD-10: N39.0

• CONTRADICTIONS Hypersensitivity to any of the ingredients is possible. Risk benefits should be carefully considered when the following medical problems exist: cardiac disease (especially cardiac arrhythmias, congestive heart failure, coronary heart disease, and mitral stenosis); gastrointestinal tract obstructive disease; glaucoma; myasthenia gravis, acute urinary retention may be precipitated in obstructive uropathy (such as bladder neck obstruction due to prostatic hypertrophy).contraindicated

Adults One tablet orally 4 times per day followed by liberal fluid intake. Older Children Dosage must be individualized by physician. Not recommended for use in children six years of age or younger.

Do not exceed recommended dosage. If rapid pulse, dizziness or blurring of vision occurs, discontinue use immediately.

OVERDOSE Emesis or gastric lavage. Slow intravenous administration of physostigmine in doses of 1 to 4 mg (0.5 to 1 mg in children), repeated as needed in one to two hours to reverse severe antimuscarinic symptoms. Administration of small doses of diazepam to control excitement and seizures. Artificial respiration with oxygen if needed for respiratory depression. Adequate hydration. Symptomatic treatment as necessary. If overdose is suspected, contact your local Poison Control Center or emergency room immediately. US residents can contact the US National Poison Hotline at 1-800-222-1222.

1. 1Off Label Use1713%
2. 2Fatigue129.3%
3. 3Pain118.5%
4. 4Anxiety107.8%
5. 5Cystitis Interstitial107.8%
6. 6Vision Blurred107.8%
7. 7Dizziness97.0%
8. 8Product Use Issue97.0%
9. 9Vomiting97.0%
10. 10Headache86.2%
11. 11Nausea86.2%
12. 12Tremor86.2%
13. 13Urinary Tract Infection86.2%
14. 14Diarrhoea75.4%
15. 15Maculopathy75.4%

Recent PubMed references pinned to Phenyl Salicylate as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Synthesis of Isochromans From Anacardic Acids Obtained From Cashew Nutshell Liquid (CNSL) and Their Antimicrobial Activity.
  Chemistry & biodiversity · 2026 · Davids BL, Lu T, Ngwira KJ, et al.
  PMID 41838549DOI 10.1002/cbdv.202503670
• Hydrophobicity, 3D complexity, and steric feature affect salicylate inhibition of human and rat gonadal 3β-hydroxysteroid dehydrogenases: Insights from experiments to 3D-QSAR and in silico docking analysis.
  Chemico-biological interactions · 2026 · Ren X, Chen Z, Pan C, et al.
  PMID 41812755DOI 10.1016/j.cbi.2026.112032
• An Innovative Injectable and Retrievable Drug Delivery System for Endodontic Therapy.
  Journal of endodontics · 2025 · Mahmoud AH, Sloutski A, Fu S, et al.
  PMID 40816576DOI 10.1016/j.joen.2025.08.001
• Phenyl salicylate induces neurotoxicity and early Alzheimer's disease-like symptoms through ndrg1-regulated myelin damage, increasing bace1 in zebrafish.
  The Science of the total environment · 2025 · Liu S, Li X, Jiao S, et al.
  PMID 39893810DOI 10.1016/j.scitotenv.2025.178664
• Systemic acquired resistance inducing chemicals mitigate black scurf disease in potato by activating defense-related enzymes.
  PeerJ · 2024 · Buswal MK, Punia R, Kumar M, et al.
  PMID 39575171DOI 10.7717/peerj.18470
• Physiological healing of chronic gastric ulcer is not impaired by the hydrogen sulphide (H(2)S)-releasing derivative of acetylsalicylic acid (ATB-340): functional and proteomic approaches.
  Inflammopharmacology · 2024 · Korbut E, Suski M, Śliwowski Z, et al.
  PMID 38570398DOI 10.1007/s10787-024-01458-3
• Pyrazoline scaffold: hit identification to lead synthesis and biological evaluation as antidiabetic agents.
  Future medicinal chemistry · 2023 · Sharma S, Rehman Ansari MH, Sharma K, et al.
  PMID 36655571DOI 10.4155/fmc-2022-0141
• New ruthenium complexes containing salicylic acid and derivatives induce triple-negative tumor cell death via the intrinsic apoptotic pathway.
  European journal of medicinal chemistry · 2022 · Graminha AE, Popolin C, Honorato de Araujo-Neto J, et al.
  PMID 36191406DOI 10.1016/j.ejmech.2022.114772

The 10 most recently updated of 11 ClinicalTrials.gov registrations naming Phenyl Salicylate as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Antiandrogen Therapy and Radiation Therapy With or Without Docetaxel in Treating Patients With Prostate Cancer That Has Been Removed by Surgery
  Completed · Phase 2 · Phase 3 · Interventional · 612 enrolled · NRG Oncology
  NCT03070886updated 2026-05-07
• Fenofibrate in Ulcerative Colitis
  Completed · Phase 2 · Phase 3 · Interventional · 60 enrolled · Tanta University
  NCT05753267updated 2026-05-04
• Two Studies for Patients With Unfavorable Intermediate Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a Higher Gene Risk Score, The Guidance Trial
  Active not recruiting · Phase 3 · Interventional · 2,050 enrolled · NRG Oncology
  NCT05050084updated 2026-05-04
• Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial
  Active not recruiting · Phase 3 · Interventional · 2,753 enrolled · NRG Oncology
  NCT04513717updated 2026-05-04
• Finite Androgen Ablation With or Without Abiraterone Acetate and Prednisone in Treating Patients With Recurrent Prostate Cancer
  Active not recruiting · Phase 2 · Interventional · 310 enrolled · M.D. Anderson Cancer Center
  NCT01786265updated 2026-02-20
• Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer
  Recruiting · Phase 3 · Interventional · 1,273 enrolled · SWOG Cancer Research Network
  NCT03678025updated 2025-09-11
• Repurposing Fenofibrate in Modulating mTOR/NLRP3 Inflammasome in Patients With Ulcerative Colitis
  Completed · Phase 2 · Interventional · 60 enrolled · Tanta University
  NCT05781698updated 2025-04-06
• Multifactorial Intervention to Reduce Cardiovascular Disease in Type 1 Diabetes
  Recruiting · Phase 3 · Interventional · 2,000 enrolled · Steno Diabetes Center Copenhagen
  NCT06082063updated 2025-01-10
• Nephropathy In Type 2 Diabetes and Cardio-renal Events
  Completed · Phase 4 · Interventional · 850 enrolled · University of Campania Luigi Vanvitelli
  NCT00535925updated 2020-08-03
• Endothelial Function, Lipoproteins, and Inflammation With Low HDL Cholesterol in HIV: ER Niacin Versus Fenofibrate
  Completed · Phase 2 · Interventional · 99 enrolled · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
  NCT01426438updated 2016-02-03

Frequently asked questions

How does Phenyl Salicylate work?

Mechanism-of-action class: Cyclooxygenase Inhibitors.

What is Phenyl Salicylate used for?

According to FDA labeling, Phenyl Salicylate carries indications including: Uribel Tabs are indicated for the treatment of symptoms of irritative voiding. Indicated for the relief of local symptoms, such as inflammation, hypermotility, and pain, which accompany lower urinary tract infections.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Phenyl Salicylate?

Phenyl Salicylate is classified as Other urologicals, Cyclooxygenase Inhibitors, Decreased Platelet Aggregation, Decreased Prostaglandin Production, Decreased Thromboxane Production.

What are the brand names for Phenyl Salicylate?

Phenyl Salicylate is marketed under brand names including Hyophen, Phosphasal, Prosed DS, Urelle, Uretron DS, Uribel, Uribel Tabs, Urimar Reformulated Oct 2013.

What are the contraindications for Phenyl Salicylate?

Phenyl Salicylate labeling lists contraindications including: CONTRADICTIONS Hypersensitivity to any of the ingredients is possible. Risk benefits should be carefully considered when the following medical problems exist: cardiac disease (especially cardiac arrhythmias, congestive heart failure, coronary heart disease, and mitral stenosis); gastrointestinal tract obstructive disease; glaucoma; myasthenia gravis, acute urinary retention may be precipitated in obstructive uropathy (such as bladder neck obstruction due to prostatic hypertrophy).. Always consult the full prescribing information and a clinician.