Potassium Nitrate

• Uses Helps reduce painful sensitivity of the teeth to cold, heat, acids, and sweets, or contact.

Directions Adults and children 12 years of age and older: Apply at least a 1-inch strip of the product onto a soft-bristle toothbrush. Brush teeth thoroughly for at least 1 minute twice a day (morning and evening) or as recommended by a dentist or doctor. Make sure to brush all sensitive areas of the teeth. Children under 12 years of age: Consult a dentist or doctor.

Sensitive teeth may indicate a serious problem that may need prompt care by a dentist. See your dentist if the problem persists or worsens. Do not use this product longer than 4 weeks unless recommended by a dentist or doctor.

1. 1Drug Ineffective23812%
2. 2Oral Discomfort984.9%
3. 3Product Use In Unapproved Indication954.7%
4. 4Hyperaesthesia Teeth854.2%
5. 5Fatigue824.1%
6. 6Nausea824.1%
7. 7Diarrhoea773.8%
8. 8Condition Aggravated753.7%
9. 9Drug Effective For Unapproved Indication723.6%
10. 10Pain623.1%
11. 11Headache582.9%
12. 12Fall522.6%
13. 13Toothache522.6%
14. 14Oral Pain482.4%
15. 15Weight Decreased482.4%

Recent PubMed references pinned to Potassium Nitrate as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Impact of inorganic nitrate on renal sodium excretion during saline loading in healthy adults; secondary endpoints from a randomized crossover trial.
  Physiological reports · 2026 · Østergaard AM, Rosenbæk JB, Ejlersen JA, et al.
  PMID 42237694DOI 10.14814/phy2.70919
• Reduced Nitrates/Nitrites and Natural Additives in Organic Fermented Dry-Cured Sausages: Effects on Microbiological Safety, Quality, and Consumer Acceptance.
  Journal of food science · 2026 · Argemí-Armengol I, Ripoll G, Villalba D, et al.
  PMID 41830461DOI 10.1111/1750-3841.70985
• Remineralization efficacy of nano-hydroxyapatite and potassium nitrate formulations on demineralized enamel and dentin: An in vitro surface hardness and EDX-SEM study.
  Dental materials journal · 2026 · Gönüllü İ, Devrimci EE, Kemaloğlu H, et al.
  PMID 41780938DOI 10.4012/dmj.2025-144
• A clinical study examining the effects of dietary nitrate on urinary N-nitrosamines.
  The American journal of clinical nutrition · 2026 · Bondonno CP, Sundqvist ML, Shinde S, et al.
  PMID 41724486DOI 10.1016/j.ajcnut.2026.101239
• Potassium nitrate seed priming enhances root system architecture and metabolic activity in tomato (Solanum lycopersicum L).
  BMC plant biology · 2026 · Kaushal K, Yadav S, Choudhary R, et al.
  PMID 41663929DOI 10.1186/s12870-025-08013-4
• Novel approach to nitrate and macro-elements: carcino-spectrum of human health risk projections.
  Environmental monitoring and assessment · 2026 · Sahu K, Chakma S, Rao YRS, et al.
  PMID 41547700DOI 10.1007/s10661-025-14974-8
• Microshear Bond Strength of Composite Resin to Mineral Trioxide Aggregate and Potassium Nitrate-Modified Polycarboxylate Cement at Two Time Points Using Different Adhesive Approaches: An In Vitro Study.
  Clinical and experimental dental research · 2026 · Adl A, Jowkar Z, Zerafat M, et al.
  PMID 41510681DOI 10.1002/cre2.70287
• Nicorandil attenuates thioacetamide induced liver fibrosis via AMPK, SIRT1 and HIF1α mediated cellular energy homeostasis.
  Scientific reports · 2025 · Kozman MR, Ewees MGE, Ahmed YM, et al.
  PMID 41365955DOI 10.1038/s41598-025-28309-7

The 10 most recently updated of 98 ClinicalTrials.gov registrations naming Potassium Nitrate as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Evaluation of Adding Nitrate Into Foods for Regulating Nitric Oxide Bioavailability in Healthy Individuals
  Recruiting · Interventional · 30 enrolled · Queen Mary University of London
  NCT07172425updated 2026-06-04
• Matching Perfusion and Metabolic Activity in HFpEF
  Recruiting · Phase 2 · Interventional · 53 enrolled · University of Pennsylvania
  NCT04913805updated 2026-06-02
• Efficacy of an Experimental Gel Based on Libidibia Ferrea on Post-bleaching Tooth Sensitivity
  Not yet recruiting · Interventional · 75 enrolled · Universidade Federal do Para
  NCT07599514updated 2026-05-22
• Evaluation of In-office Bleaching-induced Sensitivity With 2 or 7 Days Interval Between Sessions
  Completed · Interventional · 47 enrolled · Universidade Federal Fluminense
  NCT06394557updated 2026-05-15
• Effects of an Experimental Propolis Gel on Tooth Sensitivity Control and Post-bleaching Color Change: a Randomized Clinical Trial
  Not yet recruiting · Interventional · 66 enrolled · Universidade Federal do Para
  NCT07569276updated 2026-05-06
• The Inorganic Nitrate and eXercise Performance in Heart Failure (iNIX-HF)
  Recruiting · Phase 2 · Interventional · 75 enrolled · Washington University School of Medicine
  NCT05562167updated 2026-05-06
• SGLT2i and KNO3 in HFpEF - The SAK HFpEF Trial
  Recruiting · Phase 2 · Interventional · 53 enrolled · University of Pennsylvania
  NCT05138575updated 2026-04-16
• A Study to Investigate the Tooth Whitening and Dentin Hypersensitivity Effectiveness of Two Experimental Toothpastes
  Completed · Interventional · 254 enrolled · HALEON
  NCT07297732updated 2026-03-31
• Hypersensitivity Reduction Efficacy: 5% Potassium Nitrate Toothpaste Compared to Colgate Cavity Protection Toothpaste
  Completed · Phase 3 · Interventional · 80 enrolled · Colgate Palmolive
  NCT06956599updated 2026-03-19
• Bioadhesive Film of Acmella Oleracea (Jambu) in the Reduction of Post-bleaching Dental Sensitivity Caused by Bleaching With 35% Hydrogen Peroxide.
  Completed · Phase 3 · Interventional · 72 enrolled · Universidade Federal do Para
  NCT07478640updated 2026-03-17

Frequently asked questions

What is Potassium Nitrate used for?

According to FDA labeling, Potassium Nitrate carries indications including: Uses Helps reduce painful sensitivity of the teeth to cold, heat, acids, and sweets, or contact.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What are the brand names for Potassium Nitrate?

Potassium Nitrate is marketed under brand names including Avoca, Fluoridex Daily Defense Sensitivity, Fluorimax Sensitive, Prevident 5000 Sensitive, Styptstix.