Pramoxine

Mechanism-of-action class: Unknown Cellular or Molecular Interaction.

• Uses For the temporary relief of: • Pain, itching, and burning associated with minor external vaginal irritation • Minor skin irritation and discomfort in the external genital area

Directions For adult women 18 years and older : • Wet external vaginal area with warm water. • Dispense a small amount of wash into your hands or onto a clean washcloth. • Gently cleanse the external vaginal area only. • Allow wash to remain on skin for 30–60 seconds. • Rinse thoroughly with warm water. • Pat dry. • Use once or twice daily.

For external use only. Do not use inside the vagina. Avoid contact with the eyes. If contact occurs, rinse thoroughly with water. Ask a doctor before use if you are pregnant or breastfeeding. When using this product : • Do not apply to open wounds, broken skin, or active rashes. • Do not apply more than 2 times daily. • If irritation worsens after use, discontinue immediately. • Rinse thoroughly after each use — do not leave product on skin. Stop use and ask a doctor if: • Symptoms persist for more than 7 days. • Symptoms clear up and return within a few days. • You experience unusual vaginal discharge, fever, foul odor, or pelvic pain. • Symptoms worsen at any time. • A rash or allergic reaction develops. Keep out of reach of children . If swallowed, contact a Poison Control Center immediately at 1-800-222-1222 or seek emergency medical assistance

• Jan 7, 1977ANDAANDA085368Legacy Pharma
• Jun 5, 1978ANDAANDA085979Legacy Pharma
• Jun 5, 1978ANDAANDA085980Legacy Pharma
• Jul 26, 1978ANDAANDA086195Mylan Speciality Lp
• Dec 19, 1979ANDAANDA086457Mylan Speciality Lp

1. 1Drug Ineffective2767.7%
2. 2Off Label Use2507.0%
3. 3Diarrhoea2276.3%
4. 4Rash2236.2%
5. 5Fatigue1915.3%
6. 6Nausea1865.2%
7. 7Dyspnoea1664.6%
8. 8Pruritus1574.4%
9. 9Dizziness1534.3%
10. 10Product Quality Issue1524.2%
11. 11Pain1514.2%
12. 12Headache1454.0%
13. 13Cough1393.9%
14. 14Vomiting1153.2%
15. 15Malaise1103.1%

The 5 most recently updated of 5 ClinicalTrials.gov registrations naming Pramoxine as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Double-blind, Randomized Trial of PRAX-628 in Adults With Focal Seizures to Evaluate Efficacy and Safety (POWER1)
  Recruiting · Phase 2 · Phase 3 · Interventional · 230 enrolled · Praxis Precision Medicines
  NCT06999902updated 2025-05-31
• Topical CBD's Effects on Soreness and Performance
  Completed · Interventional · 30 enrolled · Joseph Pastina
  NCT06320327updated 2024-03-20
• Study Determining Safety and Efficacy of Avena Sativa (Oat) Skincare Products for Treating Skin Dryness and Itching in Cancer Patients
  Completed · Interventional · 53 enrolled · Johnson & Johnson Consumer Inc. (J&JCI)
  NCT03796052updated 2020-11-04
• Comparative Study of the Efficacy of SARNA Sensitive Lotion for Treatment of Uremic Itch in Adult Hemodialysis Patients
  Completed · Phase 4 · Interventional · 28 enrolled · Wake Forest University
  NCT00693654updated 2018-09-10
• The Safety of Proctofoam-HC in the Third Trimester of Pregnancy
  Completed · Observational · 408 enrolled · The Hospital for Sick Children
  NCT00405288updated 2014-02-05

Frequently asked questions

How does Pramoxine work?

Mechanism-of-action class: Unknown Cellular or Molecular Interaction.

What is Pramoxine used for?

According to FDA labeling, Pramoxine carries indications including: Uses For the temporary relief of: • Pain, itching, and burning associated with minor external vaginal irritation • Minor skin irritation and discomfort in the external genital area. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Pramoxine?

Pramoxine is classified as Anesthetics for topical use, Local anesthetics, Unknown Cellular or Molecular Interaction, Decreased Sensory-Somatic Nervous System Organized Electrical Activity.

What are the brand names for Pramoxine?

Pramoxine is marketed under brand names including AmLactin AP, Analpram HC, Calaclear, Caladryl, Caladryl Clear, Calagesic, Callergy Clear, Cortane-B.