Pyrantel

Mechanism-of-action class: Cholinesterase Inhibitors.

• Use For the treatment of pinworms.

Directions READ THE PACKAGE CAREFULLY BEFORE TAKING THIS MEDICATION. take only according to directions do not exceed the recommended dosage, unless directed by a doctor medication should only be taken one time as a single dose; do not repeat treatment when one individual in a household has pinworms, the entire household should be treated unless otherwise advised adults, children 12 years of age and over, and children 2 years to under 12 years of age: this product can be taken any time of day, with or without meals. It may be taken alone or with milk or fruit juice. use of a laxative is not necessary before, during, or after medication oral dosage is a single dose of 5 mg of pyrantel base per pound or 11 mg of pyrantel base per kilogram of body weight not to exceed 1 gram (1000mg) children under 25 lbs. or 2yrs old: do not use unless directed by a doctor Weight Dosage (taken as a single (1) dose as per weight) Less than 25 lb. or under 2 yrs. old do not use unless directed by a doctor 25-37 lbs. 2 tablets (125 mg) 38-62 lbs. 4 tablets (250 mg) 63-87 lbs. 6 tablets (375 mg) 88-112 lbs. 8 tablets (500 mg) 113-137 lbs. 10 tablets (625 mg) 138-162 lbs. 12 tablets (750 mg) 163-187 lbs. 14 tablets (875 mg) 188 lbs. and over 16 tablets (1,000 mg)

Ask a doctor before use if you have liver disease are pregnant Stop use and ask a doctor if any symptoms or pinworms are still present after treatment any worms other than pinworms are present before or after treatment any of these symptoms that sometimes occur after taking the product persist: abdominal cramps nausea vomiting diarrhea headache dizziness Keep out of reach of children. In case of an accidental overdose get medical help or contact a Poison Control Center right away.

1. 1Adverse Event1737%
2. 2Drug Ineffective48.7%
3. 3Enterobiasis48.7%
4. 4Headache36.5%
5. 5Treatment Failure36.5%
6. 6Helminthic Infection24.3%
7. 7Inappropriate Schedule Of Product Administration24.3%
8. 8Accident At Work12.2%
9. 9Accidental Overdose12.2%
10. 10Anal Fungal Infection12.2%
11. 11Anxiety12.2%
12. 12Blindness12.2%
13. 13Brain Natriuretic Peptide Increased12.2%
14. 14Bronchitis12.2%
15. 15Candida Infection12.2%

Recent PubMed references pinned to Pyrantel as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Field study evaluating the efficacy of a combination formulation of fluralaner with moxidectin and pyrantel (BRAVECTO(®) TriUNO) against canine intestinal nematode infections.
  Parasites & vectors · 2026 · Chiummo R, Zschiesche E, Kirkova Z, et al.
  PMID 41928261DOI 10.1186/s13071-026-07348-7
• Field efficacy of a combination of afoxolaner, moxidectin and pyrantel pamoate against natural infestation with Otodectes cynotis in dogs.
  Parasite (Paris, France) · 2026 · Tielemans E, Sioutas G, Papadopoulos E, et al.
  PMID 41854285DOI 10.1051/parasite/2026015
• Efficacy evaluation of a new oral chewable tablet containing fluralaner, moxidectin, and pyrantel (BRAVECTO(®) TriUNO) against hookworm and Toxascaris leonina infections in a non-terminal study design in dogs.
  Parasites & vectors · 2026 · Heinau L, Petersen I, Rohdich N, et al.
  PMID 41634831DOI 10.1186/s13071-025-07232-w
• Field efficacy assessment of a combination of afoxolaner, moxidectin and pyrantel pamoate to treat dogs naturally infested with Sarcoptes scabiei.
  Parasite (Paris, France) · 2026 · Antoine L, Papadopoulos E, Sioutas G, et al.
  PMID 41568903DOI 10.1051/parasite/2026001
• Efficacy of oral afoxolaner and a combination of afoxolaner, moxidectin, and pyrantel against Amblyomma maculatum in dogs.
  Parasites & vectors · 2025 · Prullage J, Shryock J, Dumont P, et al.
  PMID 41413598DOI 10.1186/s13071-025-07186-z
• Long-term safety of Credelio Quattro™ (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets), a novel orally administered combination endectocide for dogs.
  Parasites & vectors · 2025 · Riggs KL, Wang X, Wiseman S, et al.
  PMID 41398970DOI 10.1186/s13071-025-07201-3
• Safety and efficacy assessment of a chewable tablet containing sarolaner, moxidectin, and pyrantel in the treatment of Angiostrongylus vasorum in dogs.
  Veterinary parasitology · 2026 · Lloyd A, Van Mechelen L, Van Overloop C, et al.
  PMID 41259838DOI 10.1016/j.vetpar.2025.110652
• Treatment efficacy of pyrantel, fenbendazole and macrocyclic lactones in equine strongyles in Germany using FECRT and the model eggCounts.
  Journal of equine veterinary science · 2025 · Döberl J, Li Z, Furrer R, et al.
  PMID 41177198DOI 10.1016/j.jevs.2025.105715

The 10 most recently updated of 34 ClinicalTrials.gov registrations naming Pyrantel as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Acute Effects of Radiofrequency Diathermy in Postpartum Women With Diastasis Abdominis
  Recruiting · Interventional · 48 enrolled · University of Valencia
  NCT07419399updated 2026-02-19
• Exercise Intervention Targeting Hip Strengthening Compared to Usual Care in Patients Undergoing Revision Hip Replacement
  Active not recruiting · Interventional · 84 enrolled · University of Aarhus
  NCT05657054updated 2026-01-26
• Muscle Function and Tenderness Differences in Headache Patients
  Enrolling by invitation · Observational · 90 enrolled · Danish Headache Center
  NCT06859463updated 2025-03-10
• Radiofrequency Denervation and Brain Imaging
  Recruiting · Observational · 40 enrolled · University of Aberdeen
  NCT05641948updated 2024-12-24
• Intervention on Bone Health in Wheelchair Users
  Completed · Interventional · 45 enrolled · Norwegian School of Sport Sciences
  NCT05615402updated 2024-12-05
• Aerobic Vs Neuromuscular Exercise for Knee OA
  Recruiting · Interventional · 150 enrolled · Frederiksberg University Hospital
  NCT06170229updated 2024-09-05
• Effectiveness of Manual Therapy and Neuromuscular Training in the Management of Knee Osteoarthritis
  Completed · Interventional · 60 enrolled · University of Tabuk
  NCT05659849updated 2024-07-25
• Exercise Therapy in Combination With Central Nervous System-targeted Treatment for Osteoarthritis
  Completed · Interventional · 121 enrolled · University of Valencia
  NCT03681613updated 2024-07-23
• Progressive Resistance Training Compared to Neuromuscular Exercise in Patients With Hip Osteoarthritis
  Completed · Interventional · 160 enrolled · University of Aarhus
  NCT04714047updated 2024-05-24
• Addition of Transcranial Direct Current Stimulation and Transcutaneous Electrical Nerve Stimulation to an Education and Exercise Program in Subjects With Chronic Pain Due to Knee Osteoarthritis
  Completed · Interventional · 65 enrolled · Universidad de Murcia
  NCT05138471updated 2024-05-08

Frequently asked questions

How does Pyrantel work?

Mechanism-of-action class: Cholinesterase Inhibitors.

What is Pyrantel used for?

According to FDA labeling, Pyrantel carries indications including: Use For the treatment of pinworms.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Pyrantel?

Pyrantel is classified as Tetrahydropyrimidine derivatives, Cholinesterase Inhibitors, Increased Acetylcholine Activity.

What are the brand names for Pyrantel?

Pyrantel is marketed under brand names including Ascarel, Drontal, Drontal Plus, Equistrength, Exodus, GiarcidiaZap-Wormer, Heartgard Plus, Iverhart.