Pyrilamine
GET
/api/v1/drug/pyrilamineMechanism of action
Sourced from openFDAMechanism-of-action class: Histamine H1 Receptor Antagonists.
Histamine H1 Receptor
Indications
Sourced from openFDA- Uses ■ temporarily relieves runny nose and alleviates sneezing, itching of the nose or throat, and itchy, watery eyes due to hay fever or other upper respiratory allergies.
Dosage & administration
Sourced from openFDADirections ■ mL= milliliter ■ use enclosed 15 mL dose cup and keep with product ■ children 6 to under 12 years: 30 mL (2 dose cups) every 6 to 8 hours, not to exceed 4 doses in 24 hours, or as directed by a doctor ■ children under 6 years of age: consult a doctor.
Warnings & precautions
Sourced from openFDAAsk a doctor before use if the child has ■ a breathing problem such as emphysema or chronic bronchitis ■ glaucoma Ask a doctor before use if the child is taking sedatives or tranquilizers When using this product ■ marked drowsiness may occur ■ sedatives and tranquilizers may increase drowsiness ■ excitability may occur, especially in children Stop use and ask a doctor if new symptoms occur Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.
FAERS reports
Reference statistics only. FAERS reports are voluntarily submitted and are not incidence rates, safety signals, or causal evidence. Counts reflect reporting volume — how often a reaction was reported, not how often it occurs. For decision-grade use, consult openFDA and the FAERS Public Dashboard directly.
413 total reports matchedLatest report Share = reports listing the reaction ÷ total matched reports. Rows can sum to >100% because a single report often lists multiple reactions.
- 1Drug Ineffective10124%
- 2Asthenia7117%
- 3Fatigue7017%
- 4Pain7017%
- 5Abdominal Pain Upper6616%
- 6Cough6616%
- 7Pyrexia6616%
- 8Constipation6415%
- 9Dyspnoea6415%
- 10Headache6415%
- 11Tremor6115%
- 12Product Dose Omission Issue5914%
- 13General Physical Health Deterioration5714%
- 14Pneumonia5714%
- 15Anaemia5614%
Literature
Recent PubMed references pinned to Pyrilamine as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.
- Involvement of proton-coupled SLC49A4-mediated transport in the export of lysosomally trapped pyrilamine.Drug metabolism and disposition: the biological fate of chemicals · 2023 · Akino S, Yasujima T, Shibutani R, et al.PMID 37963658DOI 10.1124/dmd.123.001354
- The widely used antihistamine mepyramine causes topical pain relief through direct blockade of nociceptor sodium channels.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021 · Hao J, Brosse L, Bonnet C, et al.PMID 34758144DOI 10.1096/fj.202100976RR
- Simultaneous Determination of Dexpanthenol, Lidocaine Hydrochloride, Mepyramine Maleate and their Related Substances by a RP-HPLC Method in Topical Dosage Forms.Journal of chromatographic science · 2018 · Doganay A, Koksel B, Gundogdu SO, et al.PMID 30085004DOI 10.1093/chromsci/bmy067
- Histamine H(1) Receptor Antagonists Facilitate Electroacupuncture Analgesia.The American journal of Chinese medicine · 2018 · Lin JG, Lee YC, Tu CH, et al.PMID 29298517DOI 10.1142/S0192415X18500039
- Combined treatment with H1 and H4 receptor antagonists reduces inflammation in a mouse model of atopic dermatitis.Journal of dermatological science · 2017 · Köchling H, Schaper K, Wilzopolski J, et al.PMID 28495120DOI 10.1016/j.jdermsci.2017.04.004
- Pyrilamine-sensitive proton-coupled organic cation (H(+)/OC) antiporter for brain-specific drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2017 · Wang X, Qi B, Su H, et al.PMID 28351667DOI 10.1016/j.jconrel.2017.03.034
- Synergistic interaction between diclofenac and pyrilamine on nociception, inflammation, and gastric damage in rats.Canadian journal of physiology and pharmacology · 2017 · Ortiz MIPMID 27831743DOI 10.1139/cjpp-2016-0306
- Naproxen, paracetamol and pamabrom versus paracetamol, pyrilamine and pamabrom in primary dysmenorrhea: a randomized, double-blind clinical trial.Medwave · 2016 · Ortiz MI, Murguía-Cánovas G, Vargas-López LC, et al.PMID 27813503DOI 10.5867/medwave.2016.09.6587
Clinical trials
The 2 most recently updated of 2 ClinicalTrials.gov registrations naming Pyrilamine as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.
- Pharmacological Modulation of Peripheral Nerve ExcitabilityCompleted · Interventional · 20 enrolled · Aalborg UniversityNCT06312254updated 2025-04-30
- Efficacy and Safety of Pediatric Drugs in Nasal CongestionCompleted · Phase 3 · Interventional · 292 enrolled · EMSNCT02601235updated 2019-10-16
Frequently asked questions
- How does Pyrilamine work?
- Mechanism-of-action class: Histamine H1 Receptor Antagonists.
- What is Pyrilamine used for?
- According to FDA labeling, Pyrilamine carries indications including: Uses ■ temporarily relieves runny nose and alleviates sneezing, itching of the nose or throat, and itchy, watery eyes due to hay fever or other upper respiratory allergies.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.
- What class of drug is Pyrilamine?
- Pyrilamine is classified as Antihistamines for topical use, Substituted ethylene diamines, Histamine H1 Receptor Antagonists, Decreased Histamine Activity.
- What are the brand names for Pyrilamine?
- Pyrilamine is marketed under brand names including Ninjacof, Ninjacof A, Pamprin Multi-Symptom, Pediaclear, Poly Hist PD, Premsyn PMS, Vanacof AC.
Note. Data for
pyrilamine is illustrative MVP content compiled from public sources. pharmacopeia is for educational and informational use only and is not a substitute for professional medical advice.