Selenium Sulfide

Mechanism-of-action classes: Physiochemical Activity; Unknown Cellular or Molecular Interaction.

• Use helps prevent recurrence of flaking and itching associated with dandruff.

Directions shake well wet hair massage onto scalp rinse repeat if desired for best results use at least twice a week or as directed by a doctor for maximum dandruff control, use every time you shampoo.

For external use only When using this product avoid contact with the eyes. If contact occurs, rinse eyes thoroughly with water. Stop use and ask a doctor if condition worsens or does not improve after regular use as directed. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center (1-800-222-1222) right away.

• Jan 10, 1991ANDAANDA089996Padagis Us

1. 1Drug Ineffective12413%
2. 2Pruritus616.6%
3. 3Hair Colour Changes556.0%
4. 4No Adverse Event515.5%
5. 5Alopecia404.3%
6. 6Pain384.1%
7. 7Condition Aggravated363.9%
8. 8Nausea323.5%
9. 9Fatigue313.4%
10. 10Hair Texture Abnormal313.4%
11. 11Product Odour Abnormal303.3%
12. 12Rash272.9%
13. 13Anxiety262.8%
14. 14Off Label Use242.6%
15. 15Headache232.5%

Recent PubMed references pinned to Selenium Sulfide as a MeSH major topic. Citations link to pubmed.ncbi.nlm.nih.gov.

• Stimulus-Responsive Perselenide, Thioselenide, and Selenosulfide Donors for Reactive Selenium Species Chemical Biology.
  Journal of the American Chemical Society · 2026 · Tripathi R, Hankins RA, Yi J, et al.
  PMID 41797293DOI 10.1021/jacs.5c19556
• Polyselenylsulfides as neglected central intermediates in Selenium cycling.
  Chemosphere · 2026 · Martinez M, Lenz M
  PMID 41337894DOI 10.1016/j.chemosphere.2025.144779
• Self-Powered PEC Cathodic Immunosensor for CA125 Detection Based on the Cu(2)O Photocathode and the CdS/PANI Photoanode.
  ACS sensors · 2026 · Wang S, Wang X, Zhao F, et al.
  PMID 41268986DOI 10.1021/acssensors.5c03044
• Sandwich-structured GaIn(Zn)P/ZnSeS@ZnS quantum dots-Ag@Fe(3)O(4)@SiO(2) magnetoplasmonic nanosensor with simulation-driven design for influenza A(H1N1) virus biosensing.
  Journal of colloid and interface science · 2026 · Adeniyi KO, Gray KI, Grillo F, et al.
  PMID 41075505DOI 10.1016/j.jcis.2025.139164
• Fluorescence immunochromatographic assay based on CdSe/ZnS quantum dots for the detection of OXA-48.
  Journal of immunological methods · 2025 · Lun M, Chen Y, Liu H, et al.
  PMID 41046055DOI 10.1016/j.jim.2025.113984
• Parental exposure to CdSe/ZnS QDs affects otolith development and locomotor behavior in rare minnow (Gobiocypris rarus) offspring.
  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2026 · Xie W, Zhang Q, Jin L, et al.
  PMID 40983186DOI 10.1016/j.cbpc.2025.110360
• Thiol/disulfide homeostasis and ischemia-modified albumin as oxidative stress markers in patients with embedded fragments.
  Toxicology and industrial health · 2025 · Gündüzöz M, Büyükşekerci M, Özakıncı OG, et al.
  PMID 40899871DOI 10.1177/07482337251371774
• A Point-of-Care Optical Biosensor for α-Amylase Estimation Using CdS/ZnS Quantum Dots.
  IEEE transactions on nanobioscience · 2026 · Daurai B, Gogoi M, Saikia MJ, et al.
  PMID 40889316DOI 10.1109/TNB.2025.3604755

The 7 most recently updated of 7 ClinicalTrials.gov registrations naming Selenium Sulfide as an intervention. Registration is not evidence of efficacy or safety — reference crosswalk only.

• Evaluation and Comparison of the Benefits of Routine vs Shampoo Alone During 4 Weeks Treatment and 12 Weeks Remanence
  Completed · Observational · 80 enrolled · Vichy Laboratoires
  NCT07133334updated 2026-03-04
• Evaluation of the Benefits of Shampoo During 4 Weeks of Treatment and After 24 Weeks
  Completed · Observational · 40 enrolled · Vichy Laboratoires
  NCT07292467updated 2026-03-04
• Evaluation of the Efficacy of SeS2 Shampoo on Subjects Having Dandruff
  Unknown · Interventional · 60 enrolled · L'Oreal
  NCT05506592updated 2022-08-18
• Effects on the Scalp Lipids and TEWL of a 1% Selenium Disulfide and 1% Salicylic Acid Antidandruff Shampoo on Dandruff Scalp
  Unknown · Interventional · 40 enrolled · L'Oreal
  NCT05503706updated 2022-08-17
• Effects on the Scalp Microbiota of a 1% Selenium Disulfide and 1% Salicylic Acid Shampoo After 2% Ketaconazole Foaming Gel Treatment for Scalp Seborrheic Dermatitis
  Completed · Interventional · 80 enrolled · L'Oreal
  NCT04057950updated 2021-04-27
• The Comparative Assessment of Mycological Efficacy, Safety, Recurrence, and Cost-effectiveness of Selenium Sulfide 1.8% Shampoo Versus Ketoconazole 2% Shampoo in Pityriasis Versicolor: a Double-blind Randomized Controlled Trial
  Completed · Phase 4 · Interventional · 100 enrolled · Indonesia University
  NCT04007237updated 2019-07-05
• Selenium Sulfide, Ketoconazole and Ciclopirox Shampoo as Additional Treatments for Tinea Capitis (Scalp Ringworm)
  Completed · Interventional · 47 enrolled · Chen, Catherine, M.D.
  NCT00127868updated 2008-07-09

Frequently asked questions

How does Selenium Sulfide work?

Mechanism-of-action classes: Physiochemical Activity; Unknown Cellular or Molecular Interaction.

What is Selenium Sulfide used for?

According to FDA labeling, Selenium Sulfide carries indications including: Use helps prevent recurrence of flaking and itching associated with dandruff.. This is a reference summary of labeled uses, not medical advice or a treatment recommendation.

What class of drug is Selenium Sulfide?

Selenium Sulfide is classified as Other antifungals for topical use, Physiochemical Activity, Unknown Cellular or Molecular Interaction, Cellular Degradation/Digestion Alteration, Increased Glutathione Concentration.

What are the brand names for Selenium Sulfide?

Selenium Sulfide is marketed under brand names including Dandrex, Head & Shoulders Clinical Strength, SelRx, Selsun Blue, Tersi Foam.